@article{10.11648/j.iji.20190702.12,
  author = {Sekongo Yassongui Mamadou and Dasse Sery Romuald and Altemeyer Anaïs and Soraya Amar and Tayou Claude and Anani Ludovic and Kassogue Kadidia and Geisen Cristof and Herbrich Anne and Kouamenan Sisonie and Konate Seidou},
  title = {Prevalence of Anti Erythocyte Alloimmunization to  Sub-Saharan African Blood Donors},
  journal = {International Journal of Immunology},
  volume = {7},
  number = {2},
  pages = {33-36},
  doi = {10.11648/j.iji.20190702.12},
  url = {https://doi.org/10.11648/j.iji.20190702.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.iji.20190702.12},
  abstract = {A part from any incompatible blood transfusion, anti-erythrocyte alloimmunization is observed to pregnant women. It is the result of the passage of red blood cells carrying antigens different from those of the mother during pregnancy and delivery. The Rhesus D system is the most involved; but there are also other systems involved in this alloimmunization. Non-transfusion alloimmunization is an extremely rare event in the order of 1 of 4000 to women in Europe and in most cases concerns the Rhesus D. In sub-Saharan Africa, there are no statistics collected on foeto-maternal alloimmunization. As part of our postgraduate thesis on the sensitization status of red blood cells to acridine, we used the technique of looking for irregular agglutinins. The goal was to find anti-erythrocyte alloimmunization to blood donors in sub-Saharan Africa. We conducted a two-year multicenter prospective and descriptive study of 903 blood donors in Côte d'Ivoire, Benin and Cameroon. The samples were analyzed in the laboratories of the National Blood Transfusion Center of Côte D'Ivoire and Frankfurt according to the technique of the RAI gel card of the BIORAD company after centrifugation and incubation using test red cells treated with S-303. In the case of a positive reaction, identification is made by a panel of red blood cells in the different blood group systems. In our study population, there is a male predominance with a male/female ratio of 7.42. We found a very low prevalence of alloimmunization to non-transfused blood donors (0.9% or 8 cases out of 902). 4 anti-erythrocyte antibodies have been identified (1 Ac anti D and 3 AC anti S); 2 pan-agglutination, 2 unidentified Ac (insufficient serum) and suspicion of anti-glutathione. Anti-erythrocyte alloimmunization to sub-Saharan Africa blood donor is about 0.9% in our series. It remains high compared to European data. This alloimmunization is mainly observed to women with low frequency antigens to black peoples.},
 year = {2019}
}

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TY  - JOUR
T1  - Prevalence of Anti Erythocyte Alloimmunization to  Sub-Saharan African Blood Donors
AU  - Sekongo Yassongui Mamadou
AU  - Dasse Sery Romuald
AU  - Altemeyer Anaïs
AU  - Soraya Amar
AU  - Tayou Claude
AU  - Anani Ludovic
AU  - Kassogue Kadidia
AU  - Geisen Cristof
AU  - Herbrich Anne
AU  - Kouamenan Sisonie
AU  - Konate Seidou
Y1  - 2019/09/06
PY  - 2019
N1  - https://doi.org/10.11648/j.iji.20190702.12
DO  - 10.11648/j.iji.20190702.12
T2  - International Journal of Immunology
JF  - International Journal of Immunology
JO  - International Journal of Immunology
SP  - 33
EP  - 36
PB  - Science Publishing Group
SN  - 2329-1753
UR  - https://doi.org/10.11648/j.iji.20190702.12
AB  - A part from any incompatible blood transfusion, anti-erythrocyte alloimmunization is observed to pregnant women. It is the result of the passage of red blood cells carrying antigens different from those of the mother during pregnancy and delivery. The Rhesus D system is the most involved; but there are also other systems involved in this alloimmunization. Non-transfusion alloimmunization is an extremely rare event in the order of 1 of 4000 to women in Europe and in most cases concerns the Rhesus D. In sub-Saharan Africa, there are no statistics collected on foeto-maternal alloimmunization. As part of our postgraduate thesis on the sensitization status of red blood cells to acridine, we used the technique of looking for irregular agglutinins. The goal was to find anti-erythrocyte alloimmunization to blood donors in sub-Saharan Africa. We conducted a two-year multicenter prospective and descriptive study of 903 blood donors in Côte d'Ivoire, Benin and Cameroon. The samples were analyzed in the laboratories of the National Blood Transfusion Center of Côte D'Ivoire and Frankfurt according to the technique of the RAI gel card of the BIORAD company after centrifugation and incubation using test red cells treated with S-303. In the case of a positive reaction, identification is made by a panel of red blood cells in the different blood group systems. In our study population, there is a male predominance with a male/female ratio of 7.42. We found a very low prevalence of alloimmunization to non-transfused blood donors (0.9% or 8 cases out of 902). 4 anti-erythrocyte antibodies have been identified (1 Ac anti D and 3 AC anti S); 2 pan-agglutination, 2 unidentified Ac (insufficient serum) and suspicion of anti-glutathione. Anti-erythrocyte alloimmunization to sub-Saharan Africa blood donor is about 0.9% in our series. It remains high compared to European data. This alloimmunization is mainly observed to women with low frequency antigens to black peoples.
VL  - 7
IS  - 2
ER  - 

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