Clinico Pathological and Immunohistochemical Study in Odontogenic Cysts and Ameloblastoma (Using Laminin-1)

Amani Nour El-Din Abd El-Latif; Sahar Mohamed Elsheikh; Hashem Mohamed Hassouna

doi:doi:10.11648/j.ajls.20130103.19

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Clinico Pathological and Immunohistochemical Study in Odontogenic Cysts and Ameloblastoma (Using Laminin-1)

Amani Nour El-Din Abd El-Latif, Sahar Mohamed Elsheikh, Hashem Mohamed Hassouna

Published in American Journal of Life Sciences (Volume 1, Issue 3)

Received: 4 June 2013 Published: 30 June 2013

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Abstract

Odontogenic cysts, keratocystic odontogenic tumor and ameloblastoma are the most common forms of cystic lesions and tumors that affect the jaw bones region. Demographic profiles of these lesions have been reported in various age groups in several countries, however, few reports can be found among Egyptian population. The purpose of this study is to evaluate the prevalence of odontogenic cysts, keratocystic odontogenic tumor and ameloblastoma in patients seeking treatment in Faculty of Dentistry of Alexandria and Pharos Universities, Alexandria, Egypt in the last four years (2009-2012).To study odontogenic cysts, keratocystic odontogenic tumor and ameloblastoma clinically and histopathologically as well as to detect the immunoexpression of laminin-1. A clinical and a retrospective survey were carried out. For immunostaining, sections were immunostained with anti-laminin-1 primary antibody (#RB-082-A) according to manufactures, instructions. Statistical analysis was carried out on the tabulated data using (SPSS 16.0) software. It was found that the incidence of odontogenic cysts, keratocystic odontogenic tumor and ameloblastoma in male is slightly more than that in female, and the mandible was the most frequent affected side. Keratocystic odontogenic tumors and unicystic ameloblastoma were considered the most prevalent odontogenic tumors with an increase in the incidence of ameloblastic carcinoma in the last four years. The benign nature of some odontogenic cysts and the aggressive behavior of others could be explained by the expression of laminin-1 that may indicate that it might be valuable markers for the prediction of the biologic behavior of cystic lesions.

Published in	American Journal of Life Sciences (Volume 1, Issue 3)
DOI	10.11648/j.ajls.20130103.19
Page(s)	130-135
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2013. Published by Science Publishing Group

Keywords

Odontogenic Cysts, Keratocystic Odontogenic Tumors, Ameloblastoma, Laminin-1

References

[1]	B. G. Koseoglu, B. Atalay and M. A. Erdem, "Odontogenic Cysts: a Clinical Study of 90 Cases," Journal of Oral Science, vol. 46, No. 4, 2004, pp. 253-257.
[2]	F. Selvi1, M. S. Tekkesin, S. Cakarer 1, S. C. Isler1 and C. Keskin, "Keratocystic odontogenic Tumors: Predictive Factors of Recurrence by Ki-67 and AgNORLabelling," Int J Med Sci 2012; 9(4):262-268. doi:10.7150/ijms.4243
[3]	J. A. Regezi, "Odontogenic Cysts, Odontogenic Tumors, Fibroosseous, and Giant Cell Lesions of the Jaws," Mod Pathol, vol. 15, No. 3, 2002, pp. 331-341
[4]	S. L. Avon, J. McComb and C. Clokie, "Ameloblastic carcinoma: Case report and literature review," J Can Dent Assoc Vol. 69, 2003, 573-576.
[5]	S. Poomsawat, J. Punyasingh and W. Weerapradist, "Expression of Basement Membrane Components in Odontogenic Cysts," Oral Diseases, Vol. 12, 2006, pp. 290-296.
[6]	M. S. Ayoub, H. M. Baghdadi and M. El-Kholy, "Immunohistochemical Detection of Laminin-1 and Ki-67 in Radicular Cysts and Keratocystic odontogenic Tumors," BMC Clinical Pathology, vol. 11, 2011, pp. 4
[7]	A. de Arcangelis, O. Lefebvre, A. Mechine-Neuville, C. Arnold, A. Kline and L. Remy, "Overexpression of Laminin Alpha1 Chain in Colonic Cancer Cells Induces an Increase in Tumor Growth," Int J Cancer, vol. 94, 2001, pp. 44-53.
[8]	S. Nuñez-Urrutia, R. Figueiredoand C. Gay-Escoda, "Retrospective Clinicopathological study of 418 odontogeniccysts," Med Oral Patol Oral Cir Bucal," vol. 15, 2010, pp. e767-773.
[9]	L. B. de Souza, M. A. Gordón-Núñez, C. F. Nonaka, M. C. de Medeiros, T. F. Torres and G. B. Emiliano, "Odontogeniccysts: Demographic Profile in a Brazilian Population Over a 38-Year Period," Med Oral Patol Oral CirBucal, vol. 15, 2010, pp. e583-590.
[10]	A. Açikgöz, E. Uzun-Bulut, B. Özdenand K. Gündüz, "Prevalence and Distribution of Odontogenic and NonodontogenicCysts in a Turkish Population," Med Oral Patol Oral Cir Bucal, vol. 17, No. 1, 2012, pp. e108-115.
[11]	http://www.medicinaoral.com/medoralfree01/v17i1/medoralv17i1p108.pdf
[12]	M. A. Tawfik and M. M. Zyada, "Odontogenic Tumors in Dakahlia, Egypt: Analysis of 82 Cases," Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology," vol. 109, No. 2, 2010, pp. e67-e73.
[13]	R. A. Cawson, E. W. Odell and S. Porter, "Cawson` Essentials of Oral Pathology and Oral Medicine," 7thed, Churchill Livingstone, Edinburgh, 2002, pp. 102-121.
[14]	J. A. Regezi, J. J. Sciubba, R. C. K. Jordan, "Oral Pathology: Clinical Pathologic Correlations," 4thed, WB Saunders, St Louis, 2003, 241-254.
[15]	A. B. Bataineh, M. A. Rawashdeh and M. A. Al Qudah, "The Prevalence of Inflammatory and Developmental Odontogenic Cysts in a Jordanian Population: a Clinicopathologic Study," Quintessence Int, vol. 35, No. 10, 2004, pp. 815-819.
[16]	V. Ebenezer and B. Ramalingam, "A Cross-Sectional Survey of Prevalence of OdontogenicTumours," J Maxillofac Oral Surg, vol. 9, No. 4, 2010, 369-374.
[17]	R. S. Ramesh, S. Manjunath, T. H. Ustad, S. PaisandK. Shivakumar, Unicysticameloblastoma of the mandible - an unusual case report and review of literature Head & Neck Oncology vol. 2, 2010, p.1
[18]	http://www.headandneckoncology.org/content/2/1/1.
[19]	R. Datta, J. S. Winston, G, Diaz-Reyes, T. R. Loree, L. Myers, M. A. Kuriakose, et al, "Ameloblastic Carcinoma: Report of an Aggressive Case with Multiple Bony Metastases," Am J Otolaryngol, vol. 24, 2003, pp. 64-69.
[20]	P. Ekblom, P, Lonai, J. F. Talts, "Expression and Biological Role of Laminin-1. Matrix Biol," vol. 22, No. 1, 2003, pp. 35-47.
[21]	S. Poomsawat, J. Punyasingh and P. Vejchapipat, Expression of basement membrane components in odontogenic tumors Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology vol. 104, No. 5, 2007, pp 666-675.
[22]	P. Lapthanasupkul, S. Poomsawat and J. Chindasombatjaroen, "Investigation of Basement Membrane Proteins in a Case of Granular Cell Ameloblastoma," International Journal of Oral Science, vol. 4, 2012, pp 45-49.
[23]	S. C. A. Gurgel, G. E. A. Ramos, A. L. Melo, B. C. Schlaepfer, R. O. de Souza, C. M. Oliveira and J. N. dos Santos, "Immunolocalisation of laminin-1 in Keratocystic odontogenic tumors," ActaHistochem, vol. 112, No. 6, 2010, pp. 624-629.
[24]	H. H. Araújo,R. José, , V. Thiago, L.M.Guedes, É.J.Dantas, Glandular odontogenic cyst: case report and review of diagnostic criteria, Journal of Cranio-Maxillofacial Surgery, vol. 40, No. 2, 2012, pp e46–e50.
[25]	P.Aggarwal, S.Saxena. Aggressive growth and neoplastic potential of dentigerous cysts with particular reference to central mucoepidermoid carcinoma. Br J Oral MaxillofacSurg, vol. 49, No. 6, 2011, pp e36-9

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APA Style

Amani Nour El-Din Abd El-Latif, Sahar Mohamed Elsheikh, Hashem Mohamed Hassouna. (2013). Clinico Pathological and Immunohistochemical Study in Odontogenic Cysts and Ameloblastoma (Using Laminin-1). American Journal of Life Sciences, 1(3), 130-135. https://doi.org/10.11648/j.ajls.20130103.19

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ACS Style

Amani Nour El-Din Abd El-Latif; Sahar Mohamed Elsheikh; Hashem Mohamed Hassouna. Clinico Pathological and Immunohistochemical Study in Odontogenic Cysts and Ameloblastoma (Using Laminin-1). Am. J. Life Sci. 2013, 1(3), 130-135. doi: 10.11648/j.ajls.20130103.19

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AMA Style

Amani Nour El-Din Abd El-Latif, Sahar Mohamed Elsheikh, Hashem Mohamed Hassouna. Clinico Pathological and Immunohistochemical Study in Odontogenic Cysts and Ameloblastoma (Using Laminin-1). Am J Life Sci. 2013;1(3):130-135. doi: 10.11648/j.ajls.20130103.19

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@article{10.11648/j.ajls.20130103.19,
  author = {Amani Nour El-Din Abd El-Latif and Sahar Mohamed Elsheikh and Hashem Mohamed Hassouna},
  title = {Clinico Pathological and Immunohistochemical Study in Odontogenic Cysts and Ameloblastoma (Using Laminin-1)},
  journal = {American Journal of Life Sciences},
  volume = {1},
  number = {3},
  pages = {130-135},
  doi = {10.11648/j.ajls.20130103.19},
  url = {https://doi.org/10.11648/j.ajls.20130103.19},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajls.20130103.19},
  abstract = {Odontogenic cysts, keratocystic odontogenic tumor and ameloblastoma are the most common forms of cystic lesions and tumors that affect the jaw bones region. Demographic profiles of these lesions have been reported in various age groups in several countries, however, few reports can be found among Egyptian population. The purpose of this study is to evaluate the prevalence of odontogenic cysts, keratocystic odontogenic tumor and ameloblastoma in patients seeking treatment in Faculty of Dentistry of Alexandria and Pharos Universities, Alexandria, Egypt in the last four years (2009-2012).To study odontogenic cysts, keratocystic odontogenic tumor and ameloblastoma clinically and histopathologically as well as to detect the immunoexpression of laminin-1. A clinical and a retrospective survey were carried out. For immunostaining, sections were immunostained with anti-laminin-1 primary antibody (#RB-082-A) according to manufactures, instructions. Statistical analysis was carried out on the tabulated data using (SPSS 16.0) software. It was found that the incidence of odontogenic cysts, keratocystic odontogenic tumor and ameloblastoma in male is slightly more than that in female, and the mandible was the most frequent affected side. Keratocystic odontogenic tumors and unicystic ameloblastoma were considered the most prevalent odontogenic tumors with an increase in the incidence of ameloblastic carcinoma in the last four years. The benign nature of some odontogenic cysts and the aggressive behavior of others could be explained by the expression of laminin-1 that may indicate that it might be valuable markers for the prediction of the biologic behavior of cystic lesions.},
 year = {2013}
}

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TY  - JOUR
T1  - Clinico Pathological and Immunohistochemical Study in Odontogenic Cysts and Ameloblastoma (Using Laminin-1)
AU  - Amani Nour El-Din Abd El-Latif
AU  - Sahar Mohamed Elsheikh
AU  - Hashem Mohamed Hassouna
Y1  - 2013/06/30
PY  - 2013
N1  - https://doi.org/10.11648/j.ajls.20130103.19
DO  - 10.11648/j.ajls.20130103.19
T2  - American Journal of Life Sciences
JF  - American Journal of Life Sciences
JO  - American Journal of Life Sciences
SP  - 130
EP  - 135
PB  - Science Publishing Group
SN  - 2328-5737
UR  - https://doi.org/10.11648/j.ajls.20130103.19
AB  - Odontogenic cysts, keratocystic odontogenic tumor and ameloblastoma are the most common forms of cystic lesions and tumors that affect the jaw bones region. Demographic profiles of these lesions have been reported in various age groups in several countries, however, few reports can be found among Egyptian population. The purpose of this study is to evaluate the prevalence of odontogenic cysts, keratocystic odontogenic tumor and ameloblastoma in patients seeking treatment in Faculty of Dentistry of Alexandria and Pharos Universities, Alexandria, Egypt in the last four years (2009-2012).To study odontogenic cysts, keratocystic odontogenic tumor and ameloblastoma clinically and histopathologically as well as to detect the immunoexpression of laminin-1. A clinical and a retrospective survey were carried out. For immunostaining, sections were immunostained with anti-laminin-1 primary antibody (#RB-082-A) according to manufactures, instructions. Statistical analysis was carried out on the tabulated data using (SPSS 16.0) software. It was found that the incidence of odontogenic cysts, keratocystic odontogenic tumor and ameloblastoma in male is slightly more than that in female, and the mandible was the most frequent affected side. Keratocystic odontogenic tumors and unicystic ameloblastoma were considered the most prevalent odontogenic tumors with an increase in the incidence of ameloblastic carcinoma in the last four years. The benign nature of some odontogenic cysts and the aggressive behavior of others could be explained by the expression of laminin-1 that may indicate that it might be valuable markers for the prediction of the biologic behavior of cystic lesions.
VL  - 1
IS  - 3
ER  -

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Author Information

Amani Nour El-Din Abd El-Latif

Oral Pathology, Faculty of Dentistry, Pharos University in Alexandria, Egypt
Sahar Mohamed Elsheikh

Oral Pathology, Faculty of Dentistry, Pharos University in Alexandria, Egypt. (Corresponding author)
Hashem Mohamed Hassouna

Oral Pathology, Faculty of Dentistry, Pharos University in Alexandria, Egypt. (Corresponding author)

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Amani Nour El-Din Abd El-Latif, Sahar Mohamed Elsheikh, Hashem Mohamed Hassouna. (2013). Clinico Pathological and Immunohistochemical Study in Odontogenic Cysts and Ameloblastoma (Using Laminin-1). American Journal of Life Sciences, 1(3), 130-135. https://doi.org/10.11648/j.ajls.20130103.19

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ACS Style

Amani Nour El-Din Abd El-Latif; Sahar Mohamed Elsheikh; Hashem Mohamed Hassouna. Clinico Pathological and Immunohistochemical Study in Odontogenic Cysts and Ameloblastoma (Using Laminin-1). Am. J. Life Sci. 2013, 1(3), 130-135. doi: 10.11648/j.ajls.20130103.19

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AMA Style

Amani Nour El-Din Abd El-Latif, Sahar Mohamed Elsheikh, Hashem Mohamed Hassouna. Clinico Pathological and Immunohistochemical Study in Odontogenic Cysts and Ameloblastoma (Using Laminin-1). Am J Life Sci. 2013;1(3):130-135. doi: 10.11648/j.ajls.20130103.19

Copy | Download

@article{10.11648/j.ajls.20130103.19,
  author = {Amani Nour El-Din Abd El-Latif and Sahar Mohamed Elsheikh and Hashem Mohamed Hassouna},
  title = {Clinico Pathological and Immunohistochemical Study in Odontogenic Cysts and Ameloblastoma (Using Laminin-1)},
  journal = {American Journal of Life Sciences},
  volume = {1},
  number = {3},
  pages = {130-135},
  doi = {10.11648/j.ajls.20130103.19},
  url = {https://doi.org/10.11648/j.ajls.20130103.19},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajls.20130103.19},
  abstract = {Odontogenic cysts, keratocystic odontogenic tumor and ameloblastoma are the most common forms of cystic lesions and tumors that affect the jaw bones region. Demographic profiles of these lesions have been reported in various age groups in several countries, however, few reports can be found among Egyptian population. The purpose of this study is to evaluate the prevalence of odontogenic cysts, keratocystic odontogenic tumor and ameloblastoma in patients seeking treatment in Faculty of Dentistry of Alexandria and Pharos Universities, Alexandria, Egypt in the last four years (2009-2012).To study odontogenic cysts, keratocystic odontogenic tumor and ameloblastoma clinically and histopathologically as well as to detect the immunoexpression of laminin-1. A clinical and a retrospective survey were carried out. For immunostaining, sections were immunostained with anti-laminin-1 primary antibody (#RB-082-A) according to manufactures, instructions. Statistical analysis was carried out on the tabulated data using (SPSS 16.0) software. It was found that the incidence of odontogenic cysts, keratocystic odontogenic tumor and ameloblastoma in male is slightly more than that in female, and the mandible was the most frequent affected side. Keratocystic odontogenic tumors and unicystic ameloblastoma were considered the most prevalent odontogenic tumors with an increase in the incidence of ameloblastic carcinoma in the last four years. The benign nature of some odontogenic cysts and the aggressive behavior of others could be explained by the expression of laminin-1 that may indicate that it might be valuable markers for the prediction of the biologic behavior of cystic lesions.},
 year = {2013}
}

Copy | Download

TY  - JOUR
T1  - Clinico Pathological and Immunohistochemical Study in Odontogenic Cysts and Ameloblastoma (Using Laminin-1)
AU  - Amani Nour El-Din Abd El-Latif
AU  - Sahar Mohamed Elsheikh
AU  - Hashem Mohamed Hassouna
Y1  - 2013/06/30
PY  - 2013
N1  - https://doi.org/10.11648/j.ajls.20130103.19
DO  - 10.11648/j.ajls.20130103.19
T2  - American Journal of Life Sciences
JF  - American Journal of Life Sciences
JO  - American Journal of Life Sciences
SP  - 130
EP  - 135
PB  - Science Publishing Group
SN  - 2328-5737
UR  - https://doi.org/10.11648/j.ajls.20130103.19
AB  - Odontogenic cysts, keratocystic odontogenic tumor and ameloblastoma are the most common forms of cystic lesions and tumors that affect the jaw bones region. Demographic profiles of these lesions have been reported in various age groups in several countries, however, few reports can be found among Egyptian population. The purpose of this study is to evaluate the prevalence of odontogenic cysts, keratocystic odontogenic tumor and ameloblastoma in patients seeking treatment in Faculty of Dentistry of Alexandria and Pharos Universities, Alexandria, Egypt in the last four years (2009-2012).To study odontogenic cysts, keratocystic odontogenic tumor and ameloblastoma clinically and histopathologically as well as to detect the immunoexpression of laminin-1. A clinical and a retrospective survey were carried out. For immunostaining, sections were immunostained with anti-laminin-1 primary antibody (#RB-082-A) according to manufactures, instructions. Statistical analysis was carried out on the tabulated data using (SPSS 16.0) software. It was found that the incidence of odontogenic cysts, keratocystic odontogenic tumor and ameloblastoma in male is slightly more than that in female, and the mandible was the most frequent affected side. Keratocystic odontogenic tumors and unicystic ameloblastoma were considered the most prevalent odontogenic tumors with an increase in the incidence of ameloblastic carcinoma in the last four years. The benign nature of some odontogenic cysts and the aggressive behavior of others could be explained by the expression of laminin-1 that may indicate that it might be valuable markers for the prediction of the biologic behavior of cystic lesions.
VL  - 1
IS  - 3
ER  -

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