@article{10.11648/j.wjph.20220701.11,
  author = {Ngom Ndeye Fatou and Ndiaye Kine and Lawson AT Dela-dem and Faye Mame Awa and Faye Fulgence Abdou and Doutchi Mahamadou and Mboup Ahmadou and Diaw Abibatou and Gaye Assietou and Ndiaye Alassane and Gueye Mamadou and Ba Awa and Ka Ousseynou},
  title = {Epidemiological, Clinical, Paraclinical and Evolutionary Aspects of SARS-CoV-2 Infection in 22 HIV-Infected Patients Followed at the Fann Outpatient Treatment Center},
  journal = {World Journal of Public Health},
  volume = {7},
  number = {1},
  pages = {1-5},
  doi = {10.11648/j.wjph.20220701.11},
  url = {https://doi.org/10.11648/j.wjph.20220701.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.wjph.20220701.11},
  abstract = {Introduction: Appearig at the end of 2019, an acute respiratory disease caused by a new coronavirus (SARS-CoV-2) quickly spread from China to all parts of the world. Cardiovascular disease, hypertension, diabetes, respiratory tract diseases, and cancer, among others, are poor predictive factors for SARS-CoV-2 infection. However, it is not yet well established to date that the human immunodeficiency virus type 1 (HIV-1) increases mortality from COVID-19. We decided to describe aspectsof COVID-19 in HIV infected patients, followed up at the Outpatient Treatment Centre (CTA) in Dakar-Fann. Methodology: This was a retrospective descriptive and analytical study of PLHIV over 15 years of age followed at the Outpatient Treatment Centre in Fann in whom the diagnosis of COVID-19 was made between July 2020 and September March 2021 by the polymerase chain reaction method in time real (RT-PCR). Results: A total of 22 PLWHA had COVID-19 with a predominance of women (15/22 or 68%). The median age was 47 years (33-85). The majority (91%) were infected with HIV-1. The mean last LTCD4 count in patients before COVID-19 diagnosis was 582 cells/mm3 [51-1415]. The last viral load before SARS-CoV2 infection was undetectable in 19 patients or 86%. One patient was in virological rebound with 353.158copies/ml. Two had no available viral load, one was profile 2 (HIV-2) and one double profile (HIV1+2). One among the patients was an active smoker. Comorbidities were found in 14 patients (64%) dominated by hypertension (7/14) and obesity/overweight (6/14). One case of hepatic cytolysis due to auto-immune disease was noted. The most frequent symptoms were headache, severe asthenia, fever, anosmia, breath shortness and cough. Anti-COVID-19 therapy was initiated following to the national protocol in addition to ART (8 on ATRIPLA, 4 TLD and 2 on ATZ/r and LPV/r). Half of the patients were treated in hospital (11/22, i.e., 50%), including one in intensive care, namely the one with a virological rebound. The case lethality rate was 9% (02/22). The two deaths involved patients over 65 years of age who did not receive any vaccine, one of whom suffered from an auto-immune disease with poor treatment observance. Conclusion: Most patients were virologically controlled with a good LTCD4 level > 582 cells/mm3. The comorbidities found were identical to those already described, proving once again that HIV is probably not a separate factor. However, good monitoring of co-morbidities, support for therapeutic compliance and vaccination should enable effective control of this pandemic in HIV patients.},
 year = {2022}
}

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TY  - JOUR
T1  - Epidemiological, Clinical, Paraclinical and Evolutionary Aspects of SARS-CoV-2 Infection in 22 HIV-Infected Patients Followed at the Fann Outpatient Treatment Center
AU  - Ngom Ndeye Fatou
AU  - Ndiaye Kine
AU  - Lawson AT Dela-dem
AU  - Faye Mame Awa
AU  - Faye Fulgence Abdou
AU  - Doutchi Mahamadou
AU  - Mboup Ahmadou
AU  - Diaw Abibatou
AU  - Gaye Assietou
AU  - Ndiaye Alassane
AU  - Gueye Mamadou
AU  - Ba Awa
AU  - Ka Ousseynou
Y1  - 2022/02/16
PY  - 2022
N1  - https://doi.org/10.11648/j.wjph.20220701.11
DO  - 10.11648/j.wjph.20220701.11
T2  - World Journal of Public Health
JF  - World Journal of Public Health
JO  - World Journal of Public Health
SP  - 1
EP  - 5
PB  - Science Publishing Group
SN  - 2637-6059
UR  - https://doi.org/10.11648/j.wjph.20220701.11
AB  - Introduction: Appearig at the end of 2019, an acute respiratory disease caused by a new coronavirus (SARS-CoV-2) quickly spread from China to all parts of the world. Cardiovascular disease, hypertension, diabetes, respiratory tract diseases, and cancer, among others, are poor predictive factors for SARS-CoV-2 infection. However, it is not yet well established to date that the human immunodeficiency virus type 1 (HIV-1) increases mortality from COVID-19. We decided to describe aspectsof COVID-19 in HIV infected patients, followed up at the Outpatient Treatment Centre (CTA) in Dakar-Fann. Methodology: This was a retrospective descriptive and analytical study of PLHIV over 15 years of age followed at the Outpatient Treatment Centre in Fann in whom the diagnosis of COVID-19 was made between July 2020 and September March 2021 by the polymerase chain reaction method in time real (RT-PCR). Results: A total of 22 PLWHA had COVID-19 with a predominance of women (15/22 or 68%). The median age was 47 years (33-85). The majority (91%) were infected with HIV-1. The mean last LTCD4 count in patients before COVID-19 diagnosis was 582 cells/mm3 [51-1415]. The last viral load before SARS-CoV2 infection was undetectable in 19 patients or 86%. One patient was in virological rebound with 353.158copies/ml. Two had no available viral load, one was profile 2 (HIV-2) and one double profile (HIV1+2). One among the patients was an active smoker. Comorbidities were found in 14 patients (64%) dominated by hypertension (7/14) and obesity/overweight (6/14). One case of hepatic cytolysis due to auto-immune disease was noted. The most frequent symptoms were headache, severe asthenia, fever, anosmia, breath shortness and cough. Anti-COVID-19 therapy was initiated following to the national protocol in addition to ART (8 on ATRIPLA, 4 TLD and 2 on ATZ/r and LPV/r). Half of the patients were treated in hospital (11/22, i.e., 50%), including one in intensive care, namely the one with a virological rebound. The case lethality rate was 9% (02/22). The two deaths involved patients over 65 years of age who did not receive any vaccine, one of whom suffered from an auto-immune disease with poor treatment observance. Conclusion: Most patients were virologically controlled with a good LTCD4 level > 582 cells/mm3. The comorbidities found were identical to those already described, proving once again that HIV is probably not a separate factor. However, good monitoring of co-morbidities, support for therapeutic compliance and vaccination should enable effective control of this pandemic in HIV patients.
VL  - 7
IS  - 1
ER  - 

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