Antituberculosis Drugs Resistance and Treatment Outcomes Among Retreatment Patients in Guinea: A Five-Year Retrospective Cohort Study

Tamba Kallas Tonguino; Tamba Mina Millimouno; Boubacar Djelo Diallo; Alexandre Delamou; Nimer Ortuno Gutierrez; Mory Camara; Boubacar Bah; Oumou Younoussa Sow

doi:doi:10.11648/j.sjph.20190705.16

Antituberculosis Drugs Resistance and Treatment Outcomes Among Retreatment Patients in Guinea: A Five-Year Retrospective Cohort Study

Tamba Kallas Tonguino, Tamba Mina Millimouno, Boubacar Djelo Diallo, Alexandre Delamou, Nimer Ortuno Gutierrez, Mory Camara, Boubacar Bah, Oumou Younoussa Sow

Published in Science Journal of Public Health (Volume 7, Issue 5)

Received: 9 September 2019 Accepted: 24 September 2019 Published: 11 October 2019

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Abstract

Tuberculosis (TB) is a global outbreak whose drug resistance is a constant threat. This study aimed at describing anti-TB drugs resistance and treatment outcomes among retreatment TB patients in Guinea between 2008 and 2012. We conducted a retrospective cohort study with a sample of 558 patients aged of at least 10, who were admitted for TB retreatment and who were tested for anti-TB drugs susceptibility during the study period. Overall, 3187 retreatment TB patients were recorded from January 1, 2008 to December 31, 2012 in Guinea, of which 558 (17.5%) performed susceptibility testing to anti-TB drugs. We found overall resistance in 417 cases (74.7%) including 356 (85.4%) of multidrug resistance (MDR), 29 (6.9%) of monoresistance (isoniazid 2.9%, streptomycin 2.9%, rifampicin 0.9%, ethambutol 0.2%) and 32 (7.7% of polydrug resistance (isoniazid + streptomycin 4.3%, rifampicin + streptomycin 1.4%, isoniazid + ethambutol + streptomycin 1.0%, rifampicin + ethambutol + streptomycin 1.0%). Most of the patients (84.6%) with anti-TB drugs resistance were under 45 and labourers were mostly represented (27.8%) including drivers in majority (37.9%). MDR-TB incidence rate increased by 12.2% between 2008 (65.6%) and 2012 (77.8%), and the annual cure rate decreased gradually from 60.0% in 2009 to 45.7% in 2012. Among MDR-TB patients (n= 356), only 112 (31.5%) benefited from second-line treatment regimen, of which, 51.7% were cured, 6.3% completed treatment, 24.1% died, 6.3% were lost to follow-up and 11.6% were not evaluated. The cure rate was higher in HIV-negative patients (55.3%) than in those who were HIV-positive (35.3%) and the death rate was the highest (41.2%) in HIV-positive patients. Overall, treatment success rate was 58.0%. This study revealed a low rate of performing drug susceptibility testing, the gradual increase of the incidence of MDR-TB each year and the gradual decrease of cure rate from year to year. Besides, anti-TB drugs resistance concerned mostly drivers in our context. Prospective studies are needed for a deep understanding of the factors associated with these persistent challenges.

Published in	Science Journal of Public Health (Volume 7, Issue 5)
DOI	10.11648/j.sjph.20190705.16
Page(s)	167-173
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Antituberculosis, Resistance, Treatment Outcome, Retreatment Patients, Guinea

References

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[13]	Sangaré L, Diandé S, Badoum G, Dingtoumda B and Traoré AS. Résistance aux antituberculeux chez les cas de tuberculose pulmonaire nouveaux ou traités antérieurement au Burkina Faso. Int J Tuberc Lung Dis. 2010; 14 (11): 1424–9.
[14]	World Health Organization. Global tuberculosis report 2015. Geneva, Switzerland: World Health Organization; 2015.
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[16]	Institut National de la Statistique, Récensement Général de la Population et de l'Habitation (RGPH). Guinée: Institut National de la Statistique. Avril 2014. Available at: http://www.ins.ci/n/documents/RGPH2014_expo_dg.pdf. Accessed on: 15^th April 2018.
[17]	World Health Organization, “Definitions and reporting framework for tuberculosis_2013 revision,” Tech. Rep.WHO/HTM/TB/2013.2, World Health Organization, Geneva, Switzerland, 2013, http://apps.who.int/iris/bitstream/10665/79199/1/9789241505345eng.pdf.
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APA Style

Tamba Kallas Tonguino, Tamba Mina Millimouno, Boubacar Djelo Diallo, Alexandre Delamou, Nimer Ortuno Gutierrez, et al. (2019). Antituberculosis Drugs Resistance and Treatment Outcomes Among Retreatment Patients in Guinea: A Five-Year Retrospective Cohort Study. Science Journal of Public Health, 7(5), 167-173. https://doi.org/10.11648/j.sjph.20190705.16

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ACS Style

Tamba Kallas Tonguino; Tamba Mina Millimouno; Boubacar Djelo Diallo; Alexandre Delamou; Nimer Ortuno Gutierrez, et al. Antituberculosis Drugs Resistance and Treatment Outcomes Among Retreatment Patients in Guinea: A Five-Year Retrospective Cohort Study. Sci. J. Public Health 2019, 7(5), 167-173. doi: 10.11648/j.sjph.20190705.16

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AMA Style

Tamba Kallas Tonguino, Tamba Mina Millimouno, Boubacar Djelo Diallo, Alexandre Delamou, Nimer Ortuno Gutierrez, et al. Antituberculosis Drugs Resistance and Treatment Outcomes Among Retreatment Patients in Guinea: A Five-Year Retrospective Cohort Study. Sci J Public Health. 2019;7(5):167-173. doi: 10.11648/j.sjph.20190705.16

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@article{10.11648/j.sjph.20190705.16,
  author = {Tamba Kallas Tonguino and Tamba Mina Millimouno and Boubacar Djelo Diallo and Alexandre Delamou and Nimer Ortuno Gutierrez and Mory Camara and Boubacar Bah and Oumou Younoussa Sow},
  title = {Antituberculosis Drugs Resistance and Treatment Outcomes Among Retreatment Patients in Guinea: A Five-Year Retrospective Cohort Study},
  journal = {Science Journal of Public Health},
  volume = {7},
  number = {5},
  pages = {167-173},
  doi = {10.11648/j.sjph.20190705.16},
  url = {https://doi.org/10.11648/j.sjph.20190705.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjph.20190705.16},
  abstract = {Tuberculosis (TB) is a global outbreak whose drug resistance is a constant threat. This study aimed at describing anti-TB drugs resistance and treatment outcomes among retreatment TB patients in Guinea between 2008 and 2012. We conducted a retrospective cohort study with a sample of 558 patients aged of at least 10, who were admitted for TB retreatment and who were tested for anti-TB drugs susceptibility during the study period. Overall, 3187 retreatment TB patients were recorded from January 1, 2008 to December 31, 2012 in Guinea, of which 558 (17.5%) performed susceptibility testing to anti-TB drugs. We found overall resistance in 417 cases (74.7%) including 356 (85.4%) of multidrug resistance (MDR), 29 (6.9%) of monoresistance (isoniazid 2.9%, streptomycin 2.9%, rifampicin 0.9%, ethambutol 0.2%) and 32 (7.7% of polydrug resistance (isoniazid + streptomycin 4.3%, rifampicin + streptomycin 1.4%, isoniazid + ethambutol + streptomycin 1.0%, rifampicin + ethambutol + streptomycin 1.0%). Most of the patients (84.6%) with anti-TB drugs resistance were under 45 and labourers were mostly represented (27.8%) including drivers in majority (37.9%). MDR-TB incidence rate increased by 12.2% between 2008 (65.6%) and 2012 (77.8%), and the annual cure rate decreased gradually from 60.0% in 2009 to 45.7% in 2012. Among MDR-TB patients (n= 356), only 112 (31.5%) benefited from second-line treatment regimen, of which, 51.7% were cured, 6.3% completed treatment, 24.1% died, 6.3% were lost to follow-up and 11.6% were not evaluated. The cure rate was higher in HIV-negative patients (55.3%) than in those who were HIV-positive (35.3%) and the death rate was the highest (41.2%) in HIV-positive patients. Overall, treatment success rate was 58.0%. This study revealed a low rate of performing drug susceptibility testing, the gradual increase of the incidence of MDR-TB each year and the gradual decrease of cure rate from year to year. Besides, anti-TB drugs resistance concerned mostly drivers in our context. Prospective studies are needed for a deep understanding of the factors associated with these persistent challenges.},
 year = {2019}
}

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TY  - JOUR
T1  - Antituberculosis Drugs Resistance and Treatment Outcomes Among Retreatment Patients in Guinea: A Five-Year Retrospective Cohort Study
AU  - Tamba Kallas Tonguino
AU  - Tamba Mina Millimouno
AU  - Boubacar Djelo Diallo
AU  - Alexandre Delamou
AU  - Nimer Ortuno Gutierrez
AU  - Mory Camara
AU  - Boubacar Bah
AU  - Oumou Younoussa Sow
Y1  - 2019/10/11
PY  - 2019
N1  - https://doi.org/10.11648/j.sjph.20190705.16
DO  - 10.11648/j.sjph.20190705.16
T2  - Science Journal of Public Health
JF  - Science Journal of Public Health
JO  - Science Journal of Public Health
SP  - 167
EP  - 173
PB  - Science Publishing Group
SN  - 2328-7950
UR  - https://doi.org/10.11648/j.sjph.20190705.16
AB  - Tuberculosis (TB) is a global outbreak whose drug resistance is a constant threat. This study aimed at describing anti-TB drugs resistance and treatment outcomes among retreatment TB patients in Guinea between 2008 and 2012. We conducted a retrospective cohort study with a sample of 558 patients aged of at least 10, who were admitted for TB retreatment and who were tested for anti-TB drugs susceptibility during the study period. Overall, 3187 retreatment TB patients were recorded from January 1, 2008 to December 31, 2012 in Guinea, of which 558 (17.5%) performed susceptibility testing to anti-TB drugs. We found overall resistance in 417 cases (74.7%) including 356 (85.4%) of multidrug resistance (MDR), 29 (6.9%) of monoresistance (isoniazid 2.9%, streptomycin 2.9%, rifampicin 0.9%, ethambutol 0.2%) and 32 (7.7% of polydrug resistance (isoniazid + streptomycin 4.3%, rifampicin + streptomycin 1.4%, isoniazid + ethambutol + streptomycin 1.0%, rifampicin + ethambutol + streptomycin 1.0%). Most of the patients (84.6%) with anti-TB drugs resistance were under 45 and labourers were mostly represented (27.8%) including drivers in majority (37.9%). MDR-TB incidence rate increased by 12.2% between 2008 (65.6%) and 2012 (77.8%), and the annual cure rate decreased gradually from 60.0% in 2009 to 45.7% in 2012. Among MDR-TB patients (n= 356), only 112 (31.5%) benefited from second-line treatment regimen, of which, 51.7% were cured, 6.3% completed treatment, 24.1% died, 6.3% were lost to follow-up and 11.6% were not evaluated. The cure rate was higher in HIV-negative patients (55.3%) than in those who were HIV-positive (35.3%) and the death rate was the highest (41.2%) in HIV-positive patients. Overall, treatment success rate was 58.0%. This study revealed a low rate of performing drug susceptibility testing, the gradual increase of the incidence of MDR-TB each year and the gradual decrease of cure rate from year to year. Besides, anti-TB drugs resistance concerned mostly drivers in our context. Prospective studies are needed for a deep understanding of the factors associated with these persistent challenges.
VL  - 7
IS  - 5
ER  -

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Author Information

Tamba Kallas Tonguino

Faculty of Health Sciences and Techniques, Gamal Abdel Nasser University of Conakry, Conakry, Guinea
Tamba Mina Millimouno

Research Unit, National Training and Research Centre in Rural Health of Maferinyah, Forecariah, Guinea
Boubacar Djelo Diallo

Faculty of Health Sciences and Techniques, Gamal Abdel Nasser University of Conakry, Conakry, Guinea
Alexandre Delamou

Research Unit, National Training and Research Centre in Rural Health of Maferinyah, Forecariah, Guinea
Nimer Ortuno Gutierrez

Tuberculosis Control Project, Action Damien, Conakry, Guinea
Mory Camara

Faculty of Health Sciences and Techniques, Gamal Abdel Nasser University of Conakry, Conakry, Guinea
Boubacar Bah

Faculty of Health Sciences and Techniques, Gamal Abdel Nasser University of Conakry, Conakry, Guinea
Oumou Younoussa Sow

Faculty of Health Sciences and Techniques, Gamal Abdel Nasser University of Conakry, Conakry, Guinea

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APA Style

Tamba Kallas Tonguino, Tamba Mina Millimouno, Boubacar Djelo Diallo, Alexandre Delamou, Nimer Ortuno Gutierrez, et al. (2019). Antituberculosis Drugs Resistance and Treatment Outcomes Among Retreatment Patients in Guinea: A Five-Year Retrospective Cohort Study. Science Journal of Public Health, 7(5), 167-173. https://doi.org/10.11648/j.sjph.20190705.16

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ACS Style

Tamba Kallas Tonguino; Tamba Mina Millimouno; Boubacar Djelo Diallo; Alexandre Delamou; Nimer Ortuno Gutierrez, et al. Antituberculosis Drugs Resistance and Treatment Outcomes Among Retreatment Patients in Guinea: A Five-Year Retrospective Cohort Study. Sci. J. Public Health 2019, 7(5), 167-173. doi: 10.11648/j.sjph.20190705.16

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AMA Style

Tamba Kallas Tonguino, Tamba Mina Millimouno, Boubacar Djelo Diallo, Alexandre Delamou, Nimer Ortuno Gutierrez, et al. Antituberculosis Drugs Resistance and Treatment Outcomes Among Retreatment Patients in Guinea: A Five-Year Retrospective Cohort Study. Sci J Public Health. 2019;7(5):167-173. doi: 10.11648/j.sjph.20190705.16

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@article{10.11648/j.sjph.20190705.16,
  author = {Tamba Kallas Tonguino and Tamba Mina Millimouno and Boubacar Djelo Diallo and Alexandre Delamou and Nimer Ortuno Gutierrez and Mory Camara and Boubacar Bah and Oumou Younoussa Sow},
  title = {Antituberculosis Drugs Resistance and Treatment Outcomes Among Retreatment Patients in Guinea: A Five-Year Retrospective Cohort Study},
  journal = {Science Journal of Public Health},
  volume = {7},
  number = {5},
  pages = {167-173},
  doi = {10.11648/j.sjph.20190705.16},
  url = {https://doi.org/10.11648/j.sjph.20190705.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjph.20190705.16},
  abstract = {Tuberculosis (TB) is a global outbreak whose drug resistance is a constant threat. This study aimed at describing anti-TB drugs resistance and treatment outcomes among retreatment TB patients in Guinea between 2008 and 2012. We conducted a retrospective cohort study with a sample of 558 patients aged of at least 10, who were admitted for TB retreatment and who were tested for anti-TB drugs susceptibility during the study period. Overall, 3187 retreatment TB patients were recorded from January 1, 2008 to December 31, 2012 in Guinea, of which 558 (17.5%) performed susceptibility testing to anti-TB drugs. We found overall resistance in 417 cases (74.7%) including 356 (85.4%) of multidrug resistance (MDR), 29 (6.9%) of monoresistance (isoniazid 2.9%, streptomycin 2.9%, rifampicin 0.9%, ethambutol 0.2%) and 32 (7.7% of polydrug resistance (isoniazid + streptomycin 4.3%, rifampicin + streptomycin 1.4%, isoniazid + ethambutol + streptomycin 1.0%, rifampicin + ethambutol + streptomycin 1.0%). Most of the patients (84.6%) with anti-TB drugs resistance were under 45 and labourers were mostly represented (27.8%) including drivers in majority (37.9%). MDR-TB incidence rate increased by 12.2% between 2008 (65.6%) and 2012 (77.8%), and the annual cure rate decreased gradually from 60.0% in 2009 to 45.7% in 2012. Among MDR-TB patients (n= 356), only 112 (31.5%) benefited from second-line treatment regimen, of which, 51.7% were cured, 6.3% completed treatment, 24.1% died, 6.3% were lost to follow-up and 11.6% were not evaluated. The cure rate was higher in HIV-negative patients (55.3%) than in those who were HIV-positive (35.3%) and the death rate was the highest (41.2%) in HIV-positive patients. Overall, treatment success rate was 58.0%. This study revealed a low rate of performing drug susceptibility testing, the gradual increase of the incidence of MDR-TB each year and the gradual decrease of cure rate from year to year. Besides, anti-TB drugs resistance concerned mostly drivers in our context. Prospective studies are needed for a deep understanding of the factors associated with these persistent challenges.},
 year = {2019}
}

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TY  - JOUR
T1  - Antituberculosis Drugs Resistance and Treatment Outcomes Among Retreatment Patients in Guinea: A Five-Year Retrospective Cohort Study
AU  - Tamba Kallas Tonguino
AU  - Tamba Mina Millimouno
AU  - Boubacar Djelo Diallo
AU  - Alexandre Delamou
AU  - Nimer Ortuno Gutierrez
AU  - Mory Camara
AU  - Boubacar Bah
AU  - Oumou Younoussa Sow
Y1  - 2019/10/11
PY  - 2019
N1  - https://doi.org/10.11648/j.sjph.20190705.16
DO  - 10.11648/j.sjph.20190705.16
T2  - Science Journal of Public Health
JF  - Science Journal of Public Health
JO  - Science Journal of Public Health
SP  - 167
EP  - 173
PB  - Science Publishing Group
SN  - 2328-7950
UR  - https://doi.org/10.11648/j.sjph.20190705.16
AB  - Tuberculosis (TB) is a global outbreak whose drug resistance is a constant threat. This study aimed at describing anti-TB drugs resistance and treatment outcomes among retreatment TB patients in Guinea between 2008 and 2012. We conducted a retrospective cohort study with a sample of 558 patients aged of at least 10, who were admitted for TB retreatment and who were tested for anti-TB drugs susceptibility during the study period. Overall, 3187 retreatment TB patients were recorded from January 1, 2008 to December 31, 2012 in Guinea, of which 558 (17.5%) performed susceptibility testing to anti-TB drugs. We found overall resistance in 417 cases (74.7%) including 356 (85.4%) of multidrug resistance (MDR), 29 (6.9%) of monoresistance (isoniazid 2.9%, streptomycin 2.9%, rifampicin 0.9%, ethambutol 0.2%) and 32 (7.7% of polydrug resistance (isoniazid + streptomycin 4.3%, rifampicin + streptomycin 1.4%, isoniazid + ethambutol + streptomycin 1.0%, rifampicin + ethambutol + streptomycin 1.0%). Most of the patients (84.6%) with anti-TB drugs resistance were under 45 and labourers were mostly represented (27.8%) including drivers in majority (37.9%). MDR-TB incidence rate increased by 12.2% between 2008 (65.6%) and 2012 (77.8%), and the annual cure rate decreased gradually from 60.0% in 2009 to 45.7% in 2012. Among MDR-TB patients (n= 356), only 112 (31.5%) benefited from second-line treatment regimen, of which, 51.7% were cured, 6.3% completed treatment, 24.1% died, 6.3% were lost to follow-up and 11.6% were not evaluated. The cure rate was higher in HIV-negative patients (55.3%) than in those who were HIV-positive (35.3%) and the death rate was the highest (41.2%) in HIV-positive patients. Overall, treatment success rate was 58.0%. This study revealed a low rate of performing drug susceptibility testing, the gradual increase of the incidence of MDR-TB each year and the gradual decrease of cure rate from year to year. Besides, anti-TB drugs resistance concerned mostly drivers in our context. Prospective studies are needed for a deep understanding of the factors associated with these persistent challenges.
VL  - 7
IS  - 5
ER  -

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