Correlation Analysis of Thyroid Function and Autoantibody in Healthy Population Living in the Area of Water-Source-Originated High Level Iodine

Hou Zhenjiang; Mu Zhaoxin; Wang Fengling; Li Hongyan; Zhang Jingyu; Fan Hong; Wang Huaxin

doi:doi:10.11648/j.sjph.20170503.17

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Correlation Analysis of Thyroid Function and Autoantibody in Healthy Population Living in the Area of Water-Source-Originated High Level Iodine

Hou Zhenjiang, Mu Zhaoxin, Wang Fengling, Li Hongyan, Zhang Jingyu, Fan Hong, Wang Huaxin

Published in Science Journal of Public Health (Volume 5, Issue 3)

Received: 6 March 2017 Published: 20 March 2017

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Abstract

In order to know about the correlation between thyroid function and autoantibody of urban residents in Cangzhou, the author chose 3218 health examinations as the respondents from Cangzhou to do a research. First of all, fasting venous blood was taken from elbow in the morning. Secondly, serum was separated by centrifugation. Moreover, the positive rates of TSH, FT3, FT4, TPOAb and TgAb in serum were tested by use of Germany Roche chemiluminescence immune detection system. It finally turns out that thyroid dysfunction and positive rate of autoantibody are 7.71% and 16.19%, respectively, which have been increasing sharply along with the growth of the age, and the positive rate of female is higher than that of the male (P <0.001). Besides, the prevalence rates of hyperthyroidism, subclinical hyperthyroidism, hypothyroidism, and subclinical hypothyroidism are 0.81%, 0.68%, 1.83% and 4.38%, respectively. The prevalence rate of subclinical thyroid disease (5.07%) is significantly higher than that of clinical thyroid disease (2.64%), and the prevalence rate of clinical hypothyroidism is the highest, accounting for 56.9% of thyroid dysfunction. Positive rates of TPOAb and TgAb are 14.57% and 12.74%, respectively, while the simultaneous positive detection rate of TPOAb and TgAb is 11.12%. Through the analysis of test data, the author comes to the conclusion that thyroid dysfunction and positive rate of autoantibody have been increasing year by year, which has a great relationship with gender and age. As a result, it is important to put the determination of thyroid function and autoantibody into the routine testing and it is necessary for normal thyroid function and positive autoantibody to conduct a dynamic monitoring, follow-up or intervention in time, which is beneficial to early diagnosis, differential diagnosis and prophylaxis and treatment.

Published in	Science Journal of Public Health (Volume 5, Issue 3)
DOI	10.11648/j.sjph.20170503.17
Page(s)	198-204
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Thyroid Hormone, Thyroid Dysfunction, Thyroid Autoantibody, Health Examination

References

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APA Style

Hou Zhenjiang, Mu Zhaoxin, Wang Fengling, Li Hongyan, Zhang Jingyu, et al. (2017). Correlation Analysis of Thyroid Function and Autoantibody in Healthy Population Living in the Area of Water-Source-Originated High Level Iodine. Science Journal of Public Health, 5(3), 198-204. https://doi.org/10.11648/j.sjph.20170503.17

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ACS Style

Hou Zhenjiang; Mu Zhaoxin; Wang Fengling; Li Hongyan; Zhang Jingyu, et al. Correlation Analysis of Thyroid Function and Autoantibody in Healthy Population Living in the Area of Water-Source-Originated High Level Iodine. Sci. J. Public Health 2017, 5(3), 198-204. doi: 10.11648/j.sjph.20170503.17

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AMA Style

Hou Zhenjiang, Mu Zhaoxin, Wang Fengling, Li Hongyan, Zhang Jingyu, et al. Correlation Analysis of Thyroid Function and Autoantibody in Healthy Population Living in the Area of Water-Source-Originated High Level Iodine. Sci J Public Health. 2017;5(3):198-204. doi: 10.11648/j.sjph.20170503.17

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@article{10.11648/j.sjph.20170503.17,
  author = {Hou Zhenjiang and Mu Zhaoxin and Wang Fengling and Li Hongyan and Zhang Jingyu and Fan Hong and Wang Huaxin},
  title = {Correlation Analysis of Thyroid Function and Autoantibody in Healthy Population Living in the Area of Water-Source-Originated High Level Iodine},
  journal = {Science Journal of Public Health},
  volume = {5},
  number = {3},
  pages = {198-204},
  doi = {10.11648/j.sjph.20170503.17},
  url = {https://doi.org/10.11648/j.sjph.20170503.17},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjph.20170503.17},
  abstract = {In order to know about the correlation between thyroid function and autoantibody of urban residents in Cangzhou, the author chose 3218 health examinations as the respondents from Cangzhou to do a research. First of all, fasting venous blood was taken from elbow in the morning. Secondly, serum was separated by centrifugation. Moreover, the positive rates of TSH, FT3, FT4, TPOAb and TgAb in serum were tested by use of Germany Roche chemiluminescence immune detection system. It finally turns out that thyroid dysfunction and positive rate of autoantibody are 7.71% and 16.19%, respectively, which have been increasing sharply along with the growth of the age, and the positive rate of female is higher than that of the male (P <0.001). Besides, the prevalence rates of hyperthyroidism, subclinical hyperthyroidism, hypothyroidism, and subclinical hypothyroidism are 0.81%, 0.68%, 1.83% and 4.38%, respectively. The prevalence rate of subclinical thyroid disease (5.07%) is significantly higher than that of clinical thyroid disease (2.64%), and the prevalence rate of clinical hypothyroidism is the highest, accounting for 56.9% of thyroid dysfunction. Positive rates of TPOAb and TgAb are 14.57% and 12.74%, respectively, while the simultaneous positive detection rate of TPOAb and TgAb is 11.12%. Through the analysis of test data, the author comes to the conclusion that thyroid dysfunction and positive rate of autoantibody have been increasing year by year, which has a great relationship with gender and age. As a result, it is important to put the determination of thyroid function and autoantibody into the routine testing and it is necessary for normal thyroid function and positive autoantibody to conduct a dynamic monitoring, follow-up or intervention in time, which is beneficial to early diagnosis, differential diagnosis and prophylaxis and treatment.},
 year = {2017}
}

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TY  - JOUR
T1  - Correlation Analysis of Thyroid Function and Autoantibody in Healthy Population Living in the Area of Water-Source-Originated High Level Iodine
AU  - Hou Zhenjiang
AU  - Mu Zhaoxin
AU  - Wang Fengling
AU  - Li Hongyan
AU  - Zhang Jingyu
AU  - Fan Hong
AU  - Wang Huaxin
Y1  - 2017/03/20
PY  - 2017
N1  - https://doi.org/10.11648/j.sjph.20170503.17
DO  - 10.11648/j.sjph.20170503.17
T2  - Science Journal of Public Health
JF  - Science Journal of Public Health
JO  - Science Journal of Public Health
SP  - 198
EP  - 204
PB  - Science Publishing Group
SN  - 2328-7950
UR  - https://doi.org/10.11648/j.sjph.20170503.17
AB  - In order to know about the correlation between thyroid function and autoantibody of urban residents in Cangzhou, the author chose 3218 health examinations as the respondents from Cangzhou to do a research. First of all, fasting venous blood was taken from elbow in the morning. Secondly, serum was separated by centrifugation. Moreover, the positive rates of TSH, FT3, FT4, TPOAb and TgAb in serum were tested by use of Germany Roche chemiluminescence immune detection system. It finally turns out that thyroid dysfunction and positive rate of autoantibody are 7.71% and 16.19%, respectively, which have been increasing sharply along with the growth of the age, and the positive rate of female is higher than that of the male (P <0.001). Besides, the prevalence rates of hyperthyroidism, subclinical hyperthyroidism, hypothyroidism, and subclinical hypothyroidism are 0.81%, 0.68%, 1.83% and 4.38%, respectively. The prevalence rate of subclinical thyroid disease (5.07%) is significantly higher than that of clinical thyroid disease (2.64%), and the prevalence rate of clinical hypothyroidism is the highest, accounting for 56.9% of thyroid dysfunction. Positive rates of TPOAb and TgAb are 14.57% and 12.74%, respectively, while the simultaneous positive detection rate of TPOAb and TgAb is 11.12%. Through the analysis of test data, the author comes to the conclusion that thyroid dysfunction and positive rate of autoantibody have been increasing year by year, which has a great relationship with gender and age. As a result, it is important to put the determination of thyroid function and autoantibody into the routine testing and it is necessary for normal thyroid function and positive autoantibody to conduct a dynamic monitoring, follow-up or intervention in time, which is beneficial to early diagnosis, differential diagnosis and prophylaxis and treatment.
VL  - 5
IS  - 3
ER  -

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Author Information

Hou Zhenjiang

Institute of Thyroid Diseases, Cangzhou Medical College, Cangzhou, China
Mu Zhaoxin

Institute of Thyroid Diseases, Cangzhou Medical College, Cangzhou, China
Wang Fengling

Institute of Thyroid Diseases, Cangzhou Medical College, Cangzhou, China
Li Hongyan

Institute of Thyroid Diseases, Cangzhou Medical College, Cangzhou, China
Zhang Jingyu

Laboratory Diagnostics Division, Hebei Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou, China
Fan Hong

Laboratory Diagnostics Division, Hebei Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Cangzhou, China
Wang Huaxin

Hebei Huanghua Development Zone Bo’ai Hospital, Huanghua, China

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APA Style

Hou Zhenjiang, Mu Zhaoxin, Wang Fengling, Li Hongyan, Zhang Jingyu, et al. (2017). Correlation Analysis of Thyroid Function and Autoantibody in Healthy Population Living in the Area of Water-Source-Originated High Level Iodine. Science Journal of Public Health, 5(3), 198-204. https://doi.org/10.11648/j.sjph.20170503.17

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ACS Style

Hou Zhenjiang; Mu Zhaoxin; Wang Fengling; Li Hongyan; Zhang Jingyu, et al. Correlation Analysis of Thyroid Function and Autoantibody in Healthy Population Living in the Area of Water-Source-Originated High Level Iodine. Sci. J. Public Health 2017, 5(3), 198-204. doi: 10.11648/j.sjph.20170503.17

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AMA Style

Hou Zhenjiang, Mu Zhaoxin, Wang Fengling, Li Hongyan, Zhang Jingyu, et al. Correlation Analysis of Thyroid Function and Autoantibody in Healthy Population Living in the Area of Water-Source-Originated High Level Iodine. Sci J Public Health. 2017;5(3):198-204. doi: 10.11648/j.sjph.20170503.17

Copy | Download

@article{10.11648/j.sjph.20170503.17,
  author = {Hou Zhenjiang and Mu Zhaoxin and Wang Fengling and Li Hongyan and Zhang Jingyu and Fan Hong and Wang Huaxin},
  title = {Correlation Analysis of Thyroid Function and Autoantibody in Healthy Population Living in the Area of Water-Source-Originated High Level Iodine},
  journal = {Science Journal of Public Health},
  volume = {5},
  number = {3},
  pages = {198-204},
  doi = {10.11648/j.sjph.20170503.17},
  url = {https://doi.org/10.11648/j.sjph.20170503.17},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjph.20170503.17},
  abstract = {In order to know about the correlation between thyroid function and autoantibody of urban residents in Cangzhou, the author chose 3218 health examinations as the respondents from Cangzhou to do a research. First of all, fasting venous blood was taken from elbow in the morning. Secondly, serum was separated by centrifugation. Moreover, the positive rates of TSH, FT3, FT4, TPOAb and TgAb in serum were tested by use of Germany Roche chemiluminescence immune detection system. It finally turns out that thyroid dysfunction and positive rate of autoantibody are 7.71% and 16.19%, respectively, which have been increasing sharply along with the growth of the age, and the positive rate of female is higher than that of the male (P <0.001). Besides, the prevalence rates of hyperthyroidism, subclinical hyperthyroidism, hypothyroidism, and subclinical hypothyroidism are 0.81%, 0.68%, 1.83% and 4.38%, respectively. The prevalence rate of subclinical thyroid disease (5.07%) is significantly higher than that of clinical thyroid disease (2.64%), and the prevalence rate of clinical hypothyroidism is the highest, accounting for 56.9% of thyroid dysfunction. Positive rates of TPOAb and TgAb are 14.57% and 12.74%, respectively, while the simultaneous positive detection rate of TPOAb and TgAb is 11.12%. Through the analysis of test data, the author comes to the conclusion that thyroid dysfunction and positive rate of autoantibody have been increasing year by year, which has a great relationship with gender and age. As a result, it is important to put the determination of thyroid function and autoantibody into the routine testing and it is necessary for normal thyroid function and positive autoantibody to conduct a dynamic monitoring, follow-up or intervention in time, which is beneficial to early diagnosis, differential diagnosis and prophylaxis and treatment.},
 year = {2017}
}

Copy | Download

TY  - JOUR
T1  - Correlation Analysis of Thyroid Function and Autoantibody in Healthy Population Living in the Area of Water-Source-Originated High Level Iodine
AU  - Hou Zhenjiang
AU  - Mu Zhaoxin
AU  - Wang Fengling
AU  - Li Hongyan
AU  - Zhang Jingyu
AU  - Fan Hong
AU  - Wang Huaxin
Y1  - 2017/03/20
PY  - 2017
N1  - https://doi.org/10.11648/j.sjph.20170503.17
DO  - 10.11648/j.sjph.20170503.17
T2  - Science Journal of Public Health
JF  - Science Journal of Public Health
JO  - Science Journal of Public Health
SP  - 198
EP  - 204
PB  - Science Publishing Group
SN  - 2328-7950
UR  - https://doi.org/10.11648/j.sjph.20170503.17
AB  - In order to know about the correlation between thyroid function and autoantibody of urban residents in Cangzhou, the author chose 3218 health examinations as the respondents from Cangzhou to do a research. First of all, fasting venous blood was taken from elbow in the morning. Secondly, serum was separated by centrifugation. Moreover, the positive rates of TSH, FT3, FT4, TPOAb and TgAb in serum were tested by use of Germany Roche chemiluminescence immune detection system. It finally turns out that thyroid dysfunction and positive rate of autoantibody are 7.71% and 16.19%, respectively, which have been increasing sharply along with the growth of the age, and the positive rate of female is higher than that of the male (P <0.001). Besides, the prevalence rates of hyperthyroidism, subclinical hyperthyroidism, hypothyroidism, and subclinical hypothyroidism are 0.81%, 0.68%, 1.83% and 4.38%, respectively. The prevalence rate of subclinical thyroid disease (5.07%) is significantly higher than that of clinical thyroid disease (2.64%), and the prevalence rate of clinical hypothyroidism is the highest, accounting for 56.9% of thyroid dysfunction. Positive rates of TPOAb and TgAb are 14.57% and 12.74%, respectively, while the simultaneous positive detection rate of TPOAb and TgAb is 11.12%. Through the analysis of test data, the author comes to the conclusion that thyroid dysfunction and positive rate of autoantibody have been increasing year by year, which has a great relationship with gender and age. As a result, it is important to put the determination of thyroid function and autoantibody into the routine testing and it is necessary for normal thyroid function and positive autoantibody to conduct a dynamic monitoring, follow-up or intervention in time, which is beneficial to early diagnosis, differential diagnosis and prophylaxis and treatment.
VL  - 5
IS  - 3
ER  -

Copy | Download