The Significance of Urinary RBP and KIM-1 Determination in Cisplatin – Induced Acute Kidney Injury

Yang Haoqiang; Meng Xiaoyan; Huang Xiangyang; Tan Hechang; Zhang Min; Shu Tingting

doi:doi:10.11648/j.sjcm.20211002.16

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The Significance of Urinary RBP and KIM-1 Determination in Cisplatin – Induced Acute Kidney Injury

Yang Haoqiang, Meng Xiaoyan, Huang Xiangyang, Tan Hechang, Zhang Min, Shu Tingting

Published in Science Journal of Clinical Medicine (Volume 10, Issue 2)

Received: 6 May 2021 Accepted: 24 May 2021 Published: 25 June 2021

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Abstract

Objective: Cisplatin is one of the most commonly used and most effective chemotherapy drugs in clinical treatment of solid tumors, because of its strong anti-cancer effect, no cross resistance with other cancer drugs, but cisplatin is one of the significant renal toxicity drugs either, which greatly limits its clinical application. The traditional diagnostic methods for AKI are to measure Scr and changes in urine volume, but these indicators are affected by non-renal factors and cannot reflect renal function in an early and timely manner, which delays the optimal early treatment time for AKI. To discuss the clinical value of detecting urinary retinol binding protein (RBP) and kidney injury molecule 1 (KIM-1) in early diagonsis of cisplatin-induced acute kidney injury. Methods: 48 rats were randomly divided into the cisplatin group (CP group, 42 rats) and the control group (NS group, 6 rats). The urinary RBP and KIM-1, renal pathological changes were observed at each injection time points. Results: Urinary KIM-1 it significantly increased at 12h point (P<0.05), which was higher obviously than NS group. Urinary RBP it significantly elevated at 6h point (P<0.05). It has correlation with Scr. Conclusion: In cisplatin-induced acute kidney injury, urinary RBP and KIM-1 increased obviously earlier than serum creatinine, they were early sensitive markers.

Published in	Science Journal of Clinical Medicine (Volume 10, Issue 2)
DOI	10.11648/j.sjcm.20211002.16
Page(s)	47-51
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Cisplatin, Acute Kidney Injury, Urinary Retinol Binding Protein, Kidney Injury Molecule 1

References

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[7]	Ramesh G, Reeves WB. Salicylate is where cisplatin nephrotoxicity by inhibition of tumor necrosis factor. Kindney Int. 2016, 65 (2): 480-498.
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[15]	Tang Hua, Zou Ping. Research progress of renal injury molecule-1 [J]. International Journal of Laboratory Medicine, 2016, 8 (27): 719-723.

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APA Style

Yang Haoqiang, Meng Xiaoyan, Huang Xiangyang, Tan Hechang, Zhang Min, et al. (2021). The Significance of Urinary RBP and KIM-1 Determination in Cisplatin – Induced Acute Kidney Injury. Science Journal of Clinical Medicine, 10(2), 47-51. https://doi.org/10.11648/j.sjcm.20211002.16

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ACS Style

Yang Haoqiang; Meng Xiaoyan; Huang Xiangyang; Tan Hechang; Zhang Min, et al. The Significance of Urinary RBP and KIM-1 Determination in Cisplatin – Induced Acute Kidney Injury. Sci. J. Clin. Med. 2021, 10(2), 47-51. doi: 10.11648/j.sjcm.20211002.16

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AMA Style

Yang Haoqiang, Meng Xiaoyan, Huang Xiangyang, Tan Hechang, Zhang Min, et al. The Significance of Urinary RBP and KIM-1 Determination in Cisplatin – Induced Acute Kidney Injury. Sci J Clin Med. 2021;10(2):47-51. doi: 10.11648/j.sjcm.20211002.16

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@article{10.11648/j.sjcm.20211002.16,
  author = {Yang Haoqiang and Meng Xiaoyan and Huang Xiangyang and Tan Hechang and Zhang Min and Shu Tingting},
  title = {The Significance of Urinary RBP and KIM-1 Determination in Cisplatin – Induced Acute Kidney Injury},
  journal = {Science Journal of Clinical Medicine},
  volume = {10},
  number = {2},
  pages = {47-51},
  doi = {10.11648/j.sjcm.20211002.16},
  url = {https://doi.org/10.11648/j.sjcm.20211002.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjcm.20211002.16},
  abstract = {Objective: Cisplatin is one of the most commonly used and most effective chemotherapy drugs in clinical treatment of solid tumors, because of its strong anti-cancer effect, no cross resistance with other cancer drugs, but cisplatin is one of the significant renal toxicity drugs either, which greatly limits its clinical application. The traditional diagnostic methods for AKI are to measure Scr and changes in urine volume, but these indicators are affected by non-renal factors and cannot reflect renal function in an early and timely manner, which delays the optimal early treatment time for AKI. To discuss the clinical value of detecting urinary retinol binding protein (RBP) and kidney injury molecule 1 (KIM-1) in early diagonsis of cisplatin-induced acute kidney injury. Methods: 48 rats were randomly divided into the cisplatin group (CP group, 42 rats) and the control group (NS group, 6 rats). The urinary RBP and KIM-1, renal pathological changes were observed at each injection time points. Results: Urinary KIM-1 it significantly increased at 12h point (PConclusion: In cisplatin-induced acute kidney injury, urinary RBP and KIM-1 increased obviously earlier than serum creatinine, they were early sensitive markers.},
 year = {2021}
}

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TY  - JOUR
T1  - The Significance of Urinary RBP and KIM-1 Determination in Cisplatin – Induced Acute Kidney Injury
AU  - Yang Haoqiang
AU  - Meng Xiaoyan
AU  - Huang Xiangyang
AU  - Tan Hechang
AU  - Zhang Min
AU  - Shu Tingting
Y1  - 2021/06/25
PY  - 2021
N1  - https://doi.org/10.11648/j.sjcm.20211002.16
DO  - 10.11648/j.sjcm.20211002.16
T2  - Science Journal of Clinical Medicine
JF  - Science Journal of Clinical Medicine
JO  - Science Journal of Clinical Medicine
SP  - 47
EP  - 51
PB  - Science Publishing Group
SN  - 2327-2732
UR  - https://doi.org/10.11648/j.sjcm.20211002.16
AB  - Objective: Cisplatin is one of the most commonly used and most effective chemotherapy drugs in clinical treatment of solid tumors, because of its strong anti-cancer effect, no cross resistance with other cancer drugs, but cisplatin is one of the significant renal toxicity drugs either, which greatly limits its clinical application. The traditional diagnostic methods for AKI are to measure Scr and changes in urine volume, but these indicators are affected by non-renal factors and cannot reflect renal function in an early and timely manner, which delays the optimal early treatment time for AKI. To discuss the clinical value of detecting urinary retinol binding protein (RBP) and kidney injury molecule 1 (KIM-1) in early diagonsis of cisplatin-induced acute kidney injury. Methods: 48 rats were randomly divided into the cisplatin group (CP group, 42 rats) and the control group (NS group, 6 rats). The urinary RBP and KIM-1, renal pathological changes were observed at each injection time points. Results: Urinary KIM-1 it significantly increased at 12h point (PConclusion: In cisplatin-induced acute kidney injury, urinary RBP and KIM-1 increased obviously earlier than serum creatinine, they were early sensitive markers.
VL  - 10
IS  - 2
ER  -

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Author Information

Yang Haoqiang

Department of Nephrology, Liuzhou Worker's Hospital, Liuzhou City, China
Meng Xiaoyan

Department of Nephrology, Liuzhou Worker's Hospital, Liuzhou City, China
Huang Xiangyang

Department of Nephrology, Liuzhou Worker's Hospital, Liuzhou City, China
Tan Hechang

Department of Nephrology, Liuzhou Worker's Hospital, Liuzhou City, China
Zhang Min

Department of Nephrology, Liuzhou Worker's Hospital, Liuzhou City, China
Shu Tingting

Department of Nephrology, Liuzhou Worker's Hospital, Liuzhou City, China

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APA Style

Yang Haoqiang, Meng Xiaoyan, Huang Xiangyang, Tan Hechang, Zhang Min, et al. (2021). The Significance of Urinary RBP and KIM-1 Determination in Cisplatin – Induced Acute Kidney Injury. Science Journal of Clinical Medicine, 10(2), 47-51. https://doi.org/10.11648/j.sjcm.20211002.16

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ACS Style

Yang Haoqiang; Meng Xiaoyan; Huang Xiangyang; Tan Hechang; Zhang Min, et al. The Significance of Urinary RBP and KIM-1 Determination in Cisplatin – Induced Acute Kidney Injury. Sci. J. Clin. Med. 2021, 10(2), 47-51. doi: 10.11648/j.sjcm.20211002.16

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AMA Style

Yang Haoqiang, Meng Xiaoyan, Huang Xiangyang, Tan Hechang, Zhang Min, et al. The Significance of Urinary RBP and KIM-1 Determination in Cisplatin – Induced Acute Kidney Injury. Sci J Clin Med. 2021;10(2):47-51. doi: 10.11648/j.sjcm.20211002.16

Copy | Download

@article{10.11648/j.sjcm.20211002.16,
  author = {Yang Haoqiang and Meng Xiaoyan and Huang Xiangyang and Tan Hechang and Zhang Min and Shu Tingting},
  title = {The Significance of Urinary RBP and KIM-1 Determination in Cisplatin – Induced Acute Kidney Injury},
  journal = {Science Journal of Clinical Medicine},
  volume = {10},
  number = {2},
  pages = {47-51},
  doi = {10.11648/j.sjcm.20211002.16},
  url = {https://doi.org/10.11648/j.sjcm.20211002.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjcm.20211002.16},
  abstract = {Objective: Cisplatin is one of the most commonly used and most effective chemotherapy drugs in clinical treatment of solid tumors, because of its strong anti-cancer effect, no cross resistance with other cancer drugs, but cisplatin is one of the significant renal toxicity drugs either, which greatly limits its clinical application. The traditional diagnostic methods for AKI are to measure Scr and changes in urine volume, but these indicators are affected by non-renal factors and cannot reflect renal function in an early and timely manner, which delays the optimal early treatment time for AKI. To discuss the clinical value of detecting urinary retinol binding protein (RBP) and kidney injury molecule 1 (KIM-1) in early diagonsis of cisplatin-induced acute kidney injury. Methods: 48 rats were randomly divided into the cisplatin group (CP group, 42 rats) and the control group (NS group, 6 rats). The urinary RBP and KIM-1, renal pathological changes were observed at each injection time points. Results: Urinary KIM-1 it significantly increased at 12h point (PConclusion: In cisplatin-induced acute kidney injury, urinary RBP and KIM-1 increased obviously earlier than serum creatinine, they were early sensitive markers.},
 year = {2021}
}

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TY  - JOUR
T1  - The Significance of Urinary RBP and KIM-1 Determination in Cisplatin – Induced Acute Kidney Injury
AU  - Yang Haoqiang
AU  - Meng Xiaoyan
AU  - Huang Xiangyang
AU  - Tan Hechang
AU  - Zhang Min
AU  - Shu Tingting
Y1  - 2021/06/25
PY  - 2021
N1  - https://doi.org/10.11648/j.sjcm.20211002.16
DO  - 10.11648/j.sjcm.20211002.16
T2  - Science Journal of Clinical Medicine
JF  - Science Journal of Clinical Medicine
JO  - Science Journal of Clinical Medicine
SP  - 47
EP  - 51
PB  - Science Publishing Group
SN  - 2327-2732
UR  - https://doi.org/10.11648/j.sjcm.20211002.16
AB  - Objective: Cisplatin is one of the most commonly used and most effective chemotherapy drugs in clinical treatment of solid tumors, because of its strong anti-cancer effect, no cross resistance with other cancer drugs, but cisplatin is one of the significant renal toxicity drugs either, which greatly limits its clinical application. The traditional diagnostic methods for AKI are to measure Scr and changes in urine volume, but these indicators are affected by non-renal factors and cannot reflect renal function in an early and timely manner, which delays the optimal early treatment time for AKI. To discuss the clinical value of detecting urinary retinol binding protein (RBP) and kidney injury molecule 1 (KIM-1) in early diagonsis of cisplatin-induced acute kidney injury. Methods: 48 rats were randomly divided into the cisplatin group (CP group, 42 rats) and the control group (NS group, 6 rats). The urinary RBP and KIM-1, renal pathological changes were observed at each injection time points. Results: Urinary KIM-1 it significantly increased at 12h point (PConclusion: In cisplatin-induced acute kidney injury, urinary RBP and KIM-1 increased obviously earlier than serum creatinine, they were early sensitive markers.
VL  - 10
IS  - 2
ER  -

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