Creatinine Increase Caused by Etamsylate Interference: A Case Report of Clinical Pharmaceutical Care

Lejia Xu; Xingling Liu; Danwei Zheng; Jiawen Huang

doi:doi:10.11648/j.sjcm.20211002.14

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Creatinine Increase Caused by Etamsylate Interference: A Case Report of Clinical Pharmaceutical Care

Lejia Xu, Xingling Liu, Danwei Zheng, Jiawen Huang

Published in Science Journal of Clinical Medicine (Volume 10, Issue 2)

Received: 13 May 2021 Accepted: 28 May 2021 Published: 3 June 2021

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Abstract

Background: The accuracy of test results is closely related to the clinical diagnosis and treatment, while drugs may interfere with the test results. When the abnormal value of results occured, it is important to analyze the drug-related interferential factors. Objective: To remind clinicians and pharmacists to eliminate interference factors when finding abnormal results by recording the cause analysis process of a patient with abnormally elevated creatinine. Methods: In this case of an abnormally elevated creatinine in a patient treated with vancomycin, the clinical pharmacist analyzed the reasons of patients' creatinine elevation, especially vancomycin-associated kidney injury and other interfering factors of combination drugs in the tests. Results: The clinical pharmacist Clinical pharmacists found that acute kidney damage was not caused by vancomycin, the “real killer” was the etamsylate interference factors in laboratory test of creatinine value. This discovery enabled the patient's antibiotic treatment to proceed smoothly. Conclusions: As a clinical pharmacist, it is necessary to understand the medication situation of patients and be familiar with the common types of "drug interference detection". With these advantages in drug knowledge, clinical pharmacists can assist clinicians to identification and judgment of adverse drug reactions, and play an important role in the treatment of patients.

Published in	Science Journal of Clinical Medicine (Volume 10, Issue 2)
DOI	10.11648/j.sjcm.20211002.14
Page(s)	38-41
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Vancomycin, Creatinine, Etamsylate, Clinical Pharmacist

References

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[2]	Daiyan Kong, Xiaoli Dai, Zheng Zhang. Adverse reactions of cephalosporins [J]. Chinese Journal of Hospital Pharmacy, 2001, 21 (8): 511.
[3]	Suzhong Dai. Interference of drugs to biochemical test results [J]. Journal of Practical Medical Techniques, 2005, 12 (2): 392-393.
[4]	Qianyu Liu. Clinical progress of serum creatinine concentration [J]. International Journal of Laboratory Medicine, 1994, 15 (6): 255-258.
[5]	Rybak M, Lomaestro B, Rotschafer JC, et al. Therapeutic monitoring of vancomycin in adult patients: a consensus review of the American Society of Health-System Pharmacists, the Infectious Disease Society of America, and the Society of Infectious Diseases Pharmacists. [J] Am J Health Syst Pharm, 2009, 66 (1): 82-89.
[6]	Xiaoxiao Sun, Hua Shao, Youqun Wang. Research progress of vancomycin nephrotoxicity [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19 (5): 597-600.
[7]	Wei Li, Na Yin, Hao Jiang, et al. Analysis of drug use and pharmaceutical care for an elderly patient with plasma exchange for vancomycin-induced acute kidney injury [J]. China Pharmacy, 2018, 29 (19): 2704-2708.
[8]	Meaney CJ, Hynicka LM, Tsoukleris MG. Vancomycin-associated nephrotoxicity in adult medicine patients: incidence, outcomes, and risk factors [J]. Pharmacotherapy, 2014, 34 (7): 653-661
[9]	Wunderink RG, Niederman MS, Kollef MH, et al. Linezolid in methicillin-resistant Staphylococcusaureus nosocomial pneumonia: a randomized, controlled study [J]. Clin Infect Dis, 2012, 54 (5): 621-629.
[10]	Jeffres MN, Isakow W, Doherty JA, et al. A retrospective analysis of possible renal toxicity associated with vancomycin in patients with health care-associated methicillin-resistant Staphylococcus aureus pneumonia [J]. Clin Ther, 2007, 29 (6): 1107-1115.
[11]	Ting Mao, Jiying Li, Shenghong Wang, et al. Systematic evaluation of risk factors for intravenous dripping of vancomycin-induced acute kidney injury in Chinese patients [J]. China Pharmacy, 2018, 29 (13): 1836-1840.
[12]	Nian Ye. Clinical pharmacists participated in the pharmaceutical care of vancomycin-related acute kidney injury [J]. Journal of Military Surgeon in Southwest China, 2019, 21 (06): 558-560, 545.
[13]	Lingbo Shi, Longshun Lin. The interference of common methods in determination creatinine [J]. Chinese Journal of Laboratory Medicine, 2001, 24 (2): 102-104.
[14]	Xinmin Gu. The influence factors of creatinine determine with alkaline picric acid method [J]. Journal of traditional Chinese and western medicine, 2005, 3 (4): 356.
[15]	Yongjiang Cheng, Li Li, Haiming Chen. The interference of different methods on testing serum creatinine by ethamsylate [J]. Laboratory Medicine and Clinic, 2011, 8 (8): 1939-1941.
[16]	Drug instruction of etamsylate injection, Tianjin Jinyao Pharmaceutical Co. Ltd.

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APA Style

Lejia Xu, Xingling Liu, Danwei Zheng, Jiawen Huang. (2021). Creatinine Increase Caused by Etamsylate Interference: A Case Report of Clinical Pharmaceutical Care. Science Journal of Clinical Medicine, 10(2), 38-41. https://doi.org/10.11648/j.sjcm.20211002.14

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ACS Style

Lejia Xu; Xingling Liu; Danwei Zheng; Jiawen Huang. Creatinine Increase Caused by Etamsylate Interference: A Case Report of Clinical Pharmaceutical Care. Sci. J. Clin. Med. 2021, 10(2), 38-41. doi: 10.11648/j.sjcm.20211002.14

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AMA Style

Lejia Xu, Xingling Liu, Danwei Zheng, Jiawen Huang. Creatinine Increase Caused by Etamsylate Interference: A Case Report of Clinical Pharmaceutical Care. Sci J Clin Med. 2021;10(2):38-41. doi: 10.11648/j.sjcm.20211002.14

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@article{10.11648/j.sjcm.20211002.14,
  author = {Lejia Xu and Xingling Liu and Danwei Zheng and Jiawen Huang},
  title = {Creatinine Increase Caused by Etamsylate Interference: A Case Report of Clinical Pharmaceutical Care},
  journal = {Science Journal of Clinical Medicine},
  volume = {10},
  number = {2},
  pages = {38-41},
  doi = {10.11648/j.sjcm.20211002.14},
  url = {https://doi.org/10.11648/j.sjcm.20211002.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjcm.20211002.14},
  abstract = {Background: The accuracy of test results is closely related to the clinical diagnosis and treatment, while drugs may interfere with the test results. When the abnormal value of results occured, it is important to analyze the drug-related interferential factors. Objective: To remind clinicians and pharmacists to eliminate interference factors when finding abnormal results by recording the cause analysis process of a patient with abnormally elevated creatinine. Methods: In this case of an abnormally elevated creatinine in a patient treated with vancomycin, the clinical pharmacist analyzed the reasons of patients' creatinine elevation, especially vancomycin-associated kidney injury and other interfering factors of combination drugs in the tests. Results: The clinical pharmacist Clinical pharmacists found that acute kidney damage was not caused by vancomycin, the “real killer” was the etamsylate interference factors in laboratory test of creatinine value. This discovery enabled the patient's antibiotic treatment to proceed smoothly. Conclusions: As a clinical pharmacist, it is necessary to understand the medication situation of patients and be familiar with the common types of "drug interference detection". With these advantages in drug knowledge, clinical pharmacists can assist clinicians to identification and judgment of adverse drug reactions, and play an important role in the treatment of patients.},
 year = {2021}
}

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TY  - JOUR
T1  - Creatinine Increase Caused by Etamsylate Interference: A Case Report of Clinical Pharmaceutical Care
AU  - Lejia Xu
AU  - Xingling Liu
AU  - Danwei Zheng
AU  - Jiawen Huang
Y1  - 2021/06/03
PY  - 2021
N1  - https://doi.org/10.11648/j.sjcm.20211002.14
DO  - 10.11648/j.sjcm.20211002.14
T2  - Science Journal of Clinical Medicine
JF  - Science Journal of Clinical Medicine
JO  - Science Journal of Clinical Medicine
SP  - 38
EP  - 41
PB  - Science Publishing Group
SN  - 2327-2732
UR  - https://doi.org/10.11648/j.sjcm.20211002.14
AB  - Background: The accuracy of test results is closely related to the clinical diagnosis and treatment, while drugs may interfere with the test results. When the abnormal value of results occured, it is important to analyze the drug-related interferential factors. Objective: To remind clinicians and pharmacists to eliminate interference factors when finding abnormal results by recording the cause analysis process of a patient with abnormally elevated creatinine. Methods: In this case of an abnormally elevated creatinine in a patient treated with vancomycin, the clinical pharmacist analyzed the reasons of patients' creatinine elevation, especially vancomycin-associated kidney injury and other interfering factors of combination drugs in the tests. Results: The clinical pharmacist Clinical pharmacists found that acute kidney damage was not caused by vancomycin, the “real killer” was the etamsylate interference factors in laboratory test of creatinine value. This discovery enabled the patient's antibiotic treatment to proceed smoothly. Conclusions: As a clinical pharmacist, it is necessary to understand the medication situation of patients and be familiar with the common types of "drug interference detection". With these advantages in drug knowledge, clinical pharmacists can assist clinicians to identification and judgment of adverse drug reactions, and play an important role in the treatment of patients.
VL  - 10
IS  - 2
ER  -

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Author Information

Lejia Xu

Department of Pharmacy, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
Xingling Liu

Department of Pharmacy, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
Danwei Zheng

Department of Pharmacy, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
Jiawen Huang

Department of Pharmacy, The First Affiliated Hospital, Jinan University, Guangzhou, China

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Plain Text BibTeX RIS

APA Style

Lejia Xu, Xingling Liu, Danwei Zheng, Jiawen Huang. (2021). Creatinine Increase Caused by Etamsylate Interference: A Case Report of Clinical Pharmaceutical Care. Science Journal of Clinical Medicine, 10(2), 38-41. https://doi.org/10.11648/j.sjcm.20211002.14

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ACS Style

Lejia Xu; Xingling Liu; Danwei Zheng; Jiawen Huang. Creatinine Increase Caused by Etamsylate Interference: A Case Report of Clinical Pharmaceutical Care. Sci. J. Clin. Med. 2021, 10(2), 38-41. doi: 10.11648/j.sjcm.20211002.14

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AMA Style

Lejia Xu, Xingling Liu, Danwei Zheng, Jiawen Huang. Creatinine Increase Caused by Etamsylate Interference: A Case Report of Clinical Pharmaceutical Care. Sci J Clin Med. 2021;10(2):38-41. doi: 10.11648/j.sjcm.20211002.14

Copy | Download

@article{10.11648/j.sjcm.20211002.14,
  author = {Lejia Xu and Xingling Liu and Danwei Zheng and Jiawen Huang},
  title = {Creatinine Increase Caused by Etamsylate Interference: A Case Report of Clinical Pharmaceutical Care},
  journal = {Science Journal of Clinical Medicine},
  volume = {10},
  number = {2},
  pages = {38-41},
  doi = {10.11648/j.sjcm.20211002.14},
  url = {https://doi.org/10.11648/j.sjcm.20211002.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjcm.20211002.14},
  abstract = {Background: The accuracy of test results is closely related to the clinical diagnosis and treatment, while drugs may interfere with the test results. When the abnormal value of results occured, it is important to analyze the drug-related interferential factors. Objective: To remind clinicians and pharmacists to eliminate interference factors when finding abnormal results by recording the cause analysis process of a patient with abnormally elevated creatinine. Methods: In this case of an abnormally elevated creatinine in a patient treated with vancomycin, the clinical pharmacist analyzed the reasons of patients' creatinine elevation, especially vancomycin-associated kidney injury and other interfering factors of combination drugs in the tests. Results: The clinical pharmacist Clinical pharmacists found that acute kidney damage was not caused by vancomycin, the “real killer” was the etamsylate interference factors in laboratory test of creatinine value. This discovery enabled the patient's antibiotic treatment to proceed smoothly. Conclusions: As a clinical pharmacist, it is necessary to understand the medication situation of patients and be familiar with the common types of "drug interference detection". With these advantages in drug knowledge, clinical pharmacists can assist clinicians to identification and judgment of adverse drug reactions, and play an important role in the treatment of patients.},
 year = {2021}
}

Copy | Download

TY  - JOUR
T1  - Creatinine Increase Caused by Etamsylate Interference: A Case Report of Clinical Pharmaceutical Care
AU  - Lejia Xu
AU  - Xingling Liu
AU  - Danwei Zheng
AU  - Jiawen Huang
Y1  - 2021/06/03
PY  - 2021
N1  - https://doi.org/10.11648/j.sjcm.20211002.14
DO  - 10.11648/j.sjcm.20211002.14
T2  - Science Journal of Clinical Medicine
JF  - Science Journal of Clinical Medicine
JO  - Science Journal of Clinical Medicine
SP  - 38
EP  - 41
PB  - Science Publishing Group
SN  - 2327-2732
UR  - https://doi.org/10.11648/j.sjcm.20211002.14
AB  - Background: The accuracy of test results is closely related to the clinical diagnosis and treatment, while drugs may interfere with the test results. When the abnormal value of results occured, it is important to analyze the drug-related interferential factors. Objective: To remind clinicians and pharmacists to eliminate interference factors when finding abnormal results by recording the cause analysis process of a patient with abnormally elevated creatinine. Methods: In this case of an abnormally elevated creatinine in a patient treated with vancomycin, the clinical pharmacist analyzed the reasons of patients' creatinine elevation, especially vancomycin-associated kidney injury and other interfering factors of combination drugs in the tests. Results: The clinical pharmacist Clinical pharmacists found that acute kidney damage was not caused by vancomycin, the “real killer” was the etamsylate interference factors in laboratory test of creatinine value. This discovery enabled the patient's antibiotic treatment to proceed smoothly. Conclusions: As a clinical pharmacist, it is necessary to understand the medication situation of patients and be familiar with the common types of "drug interference detection". With these advantages in drug knowledge, clinical pharmacists can assist clinicians to identification and judgment of adverse drug reactions, and play an important role in the treatment of patients.
VL  - 10
IS  - 2
ER  -

Copy | Download