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The Correlation Between COVID 19 and IUFD: Our Experience at a Tertiary Maternity Unit in France, the CHSF

Received: 7 September 2020     Accepted: 28 September 2020     Published: 16 October 2020
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Abstract

The data concerning this infection during pregnancy is still limited. Up until now there are no clear established correlations between the COVID 19 infection during pregnancy and its potential risks for the fetus including the stillbirth issue. At our center, the frequency of occurrence of stillbirths between January - June 2019 and January - June 2020 increased. Starting from this, we aim to see if there is upon the IUFD cases of 2020 any COVID 19 infection. Most of the patients refused to do the test due to various causes. 9 patients out of 20 accepted to do the serology test. Only one tested positive and all of the others tested negative. Note that half of the patients who had negative serology have other predisposing factors for stillbirth but the only patient who tested positive does not have any other risk factors. The question is whether it is cost effective or not to do the serology test of COVID systematically in the case of pregnant patients where stillbirth occurred? Further research concerning COVID infection in pregnancy is needed. This study will be enlarged and completed with another one that will include almost nine centers at Ile de France.

Published in Science Journal of Clinical Medicine (Volume 9, Issue 4)
DOI 10.11648/j.sjcm.20200904.11
Page(s) 87-90
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Covid19, Pregnancy, Stillbirths, Serology Test, Fetal Outcome, Obstetrical Complications

References
[1] Li X, GengM, Peng Y, MengL, LuS, Molecular immune pathogenesis and diagnosis of COVID-19, Journal of Pharmaceutical Analysis, Volume 10, Issue 2, April 2020, Pages 10-108.
[2] Pierce-Williams RAM, Burd J, Felder L, et al. Clinical course of severe and critical COVID-19 in hospitalized pregnancies: a US cohort study [published online ahead of print, 2020 May 8]. Am J Obstet Gynecol MFM. 2020; 100134. doi: 10.1016/j.ajogmf.2020.100134.
[3] Lambelet V, Vouga M, Pomar L, et al. Sars-CoV-2 in the context of past coronaviruses epidemics: Consideration for prenatal care [published online ahead of print, 2020 May 26]. PrenatDiagn. 2020; 10.1002/pd.5759. doi: 10.1002/pd.5759.
[4] Huijun Chen, Juanjuan Guo, Chen Wang, Fan Luo, Xuechen Yu, Wei Zhang, Jiafu Li, Dongchi Zhao, Dan Xu, Qing Gong, Jing Liao, Huixia Yang, Wei Hou, Yuanzhen Zhang, Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records, The Lancet, Volume 395, Issue 10226, 7–13 March 2020, Pages 760-762.
[5] National Center for Health Statistics. Model state vital statistics act and regulations. Atlanta, GA: Centers for Disease Control and Prevention; 1992. Available at: https://www.cdc.gov/nchs/data/misc/mvsact92b.pdf. Retrieved September 16, 2019.
[6] Rosenstein MG, Snowden JM, Cheng YW, Caughey AB the mortality risk of expectant management compared with delivery stratified by gestational age and race and ethnicity. Am J obstetgynecol 2014; 211: 660; e1-8.
[7] Masmejan S, pomar L, Lepigeon K, Favre G, Baud D, Rieder W. COVID 19 et grossesse (COVID 19 and pregnancy). Rev Med Suisse. 2020; 16 (692): 944-946.
[8] Mullins E, Evans D, Viner RM, O'Brien P, Morris E. Coronavirus in pregnancy and delivery: rapid review. Ultrasound Obstet Gynecol. 2020; 55 (5): 586-592. doi: 10.1002/uog.22014.
[9] Yang Z, Wang M, Zhu Z, Liu Y. Coronavirus disease 2019 (COVID-19) and pregnancy: a systematic review [published online ahead of print, 2020 Apr 30]. J Matern Fetal Neonatal Med. 2020; 1-4. doi: 10.1080/14767058.2020.1759541.
[10] Della Gatta AN, Rizzo R, Pilu G, Simonazzi G. Coronavirus disease 2019 during pregnancy: a systematic review of reported cases. Am J Obstet Gynecol. 2020; 223 (1): 36-41. doi: 10.1016/j.ajog.2020.04.013.
[11] Knight M, Bunch K, Vousden N, et al. Characteristics and outcomes of pregnant women admitted to hospital with confirmed SARS-CoV-2 infection in UK: national population based cohort study. BMJ. 2020; 369: m2107. Published 2020 Jun 8. doi: 10.1136/bmj.m2107.
[12] Lokken EM, Walker CL, Delaney S, et al. Clinical Characteristics of 46 Pregnant Women with a SARS-CoV-2 Infection in Washington State [published online ahead of print, 2020 May 18]. Am J Obstet Gynecol. 2020; S0002-9378 (20) 30558-5. doi: 10.1016/j.ajog.2020.05.031.
[13] Pierce-Williams RAM, Burd J, Felder L, et al. Clinical course of severe and critical COVID-19 in hospitalized pregnancies: a US cohort study [published online ahead of print, 2020 May 8]. Am J Obstet Gynecol MFM. 2020; 100134. doi: 10.1016/j.ajogmf.2020.100134.
[14] EC, Tirado V, Lopes KD, et al. Zika virus infection in pregnancy: a systematic review of disease course and complications. Reprod Health. 2017; 14 (1): 28. Published 2017 Feb 28. doi: 10.1186/s12978-017-028.
Cite This Article
  • APA Style

    Darido Jessie, Dussour Chloe, Lehrer Jade, Grevoul Fesquet Julie, ElHachem Larissa, et al. (2020). The Correlation Between COVID 19 and IUFD: Our Experience at a Tertiary Maternity Unit in France, the CHSF. Science Journal of Clinical Medicine, 9(4), 87-90. https://doi.org/10.11648/j.sjcm.20200904.11

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    ACS Style

    Darido Jessie; Dussour Chloe; Lehrer Jade; Grevoul Fesquet Julie; ElHachem Larissa, et al. The Correlation Between COVID 19 and IUFD: Our Experience at a Tertiary Maternity Unit in France, the CHSF. Sci. J. Clin. Med. 2020, 9(4), 87-90. doi: 10.11648/j.sjcm.20200904.11

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    AMA Style

    Darido Jessie, Dussour Chloe, Lehrer Jade, Grevoul Fesquet Julie, ElHachem Larissa, et al. The Correlation Between COVID 19 and IUFD: Our Experience at a Tertiary Maternity Unit in France, the CHSF. Sci J Clin Med. 2020;9(4):87-90. doi: 10.11648/j.sjcm.20200904.11

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  • @article{10.11648/j.sjcm.20200904.11,
      author = {Darido Jessie and Dussour Chloe and Lehrer Jade and Grevoul Fesquet Julie and ElHachem Larissa and Lavergne Delphine and Khadam Louay and Rigonnot Luc},
      title = {The Correlation Between COVID 19 and IUFD: Our Experience at a Tertiary Maternity Unit in France, the CHSF},
      journal = {Science Journal of Clinical Medicine},
      volume = {9},
      number = {4},
      pages = {87-90},
      doi = {10.11648/j.sjcm.20200904.11},
      url = {https://doi.org/10.11648/j.sjcm.20200904.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjcm.20200904.11},
      abstract = {The data concerning this infection during pregnancy is still limited. Up until now there are no clear established correlations between the COVID 19 infection during pregnancy and its potential risks for the fetus including the stillbirth issue. At our center, the frequency of occurrence of stillbirths between January - June 2019 and January - June 2020 increased. Starting from this, we aim to see if there is upon the IUFD cases of 2020 any COVID 19 infection. Most of the patients refused to do the test due to various causes. 9 patients out of 20 accepted to do the serology test. Only one tested positive and all of the others tested negative. Note that half of the patients who had negative serology have other predisposing factors for stillbirth but the only patient who tested positive does not have any other risk factors. The question is whether it is cost effective or not to do the serology test of COVID systematically in the case of pregnant patients where stillbirth occurred? Further research concerning COVID infection in pregnancy is needed. This study will be enlarged and completed with another one that will include almost nine centers at Ile de France.},
     year = {2020}
    }
    

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    AB  - The data concerning this infection during pregnancy is still limited. Up until now there are no clear established correlations between the COVID 19 infection during pregnancy and its potential risks for the fetus including the stillbirth issue. At our center, the frequency of occurrence of stillbirths between January - June 2019 and January - June 2020 increased. Starting from this, we aim to see if there is upon the IUFD cases of 2020 any COVID 19 infection. Most of the patients refused to do the test due to various causes. 9 patients out of 20 accepted to do the serology test. Only one tested positive and all of the others tested negative. Note that half of the patients who had negative serology have other predisposing factors for stillbirth but the only patient who tested positive does not have any other risk factors. The question is whether it is cost effective or not to do the serology test of COVID systematically in the case of pregnant patients where stillbirth occurred? Further research concerning COVID infection in pregnancy is needed. This study will be enlarged and completed with another one that will include almost nine centers at Ile de France.
    VL  - 9
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Author Information
  • Department of Obstetrics and Gynecology, Faculty of Medical Sciences, Lebanese University, Beirut, Lebanon

  • Department of Obstetrics and Gynecology, Centre Hospitalier Sud Francilien, Ile de France, France

  • Department of Obstetrics and Gynecology, Centre Hospitalier Sud Francilien, Ile de France, France

  • Department of Obstetrics and Gynecology, Centre Hospitalier Sud Francilien, Ile de France, France

  • Department of Obstetrics and Gynecology, Centre Hospitalier Sud Francilien, Ile de France, France

  • Department of Obstetrics and Gynecology, Centre Hospitalier Sud Francilien, Ile de France, France

  • Department of Obstetrics and Gynecology, Centre Hospitalier Sud Francilien, Ile de France, France

  • Department of Obstetrics and Gynecology, Centre Hospitalier Sud Francilien, Ile de France, France

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