@article{10.11648/j.sjcm.20200903.16,
  author = {Collins Amadi and Olufisayo Gabriel Ayoade and Fabian Aniekpon Unyime and Sarah Ifreke Essien and Blessing Thomas Moses and Mfonobong Eni Enyong},
  title = {Lipid/Lipoprotein Abnormalities Among Adult Type 1 Diabetics in Nigeria},
  journal = {Science Journal of Clinical Medicine},
  volume = {9},
  number = {3},
  pages = {74-81},
  doi = {10.11648/j.sjcm.20200903.16},
  url = {https://doi.org/10.11648/j.sjcm.20200903.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjcm.20200903.16},
  abstract = {Background: Dyslipidemia abounds among diabetics. However, these are poorly characterized among patients with type 1 diabetes (T1DM). The current study determined the pattern of dyslipidemia and their relationship with glycemic status among adult T1DM subjects. Methods: This survey was conducted retrospectively among 346 newly-diagnosed/treatment-naïve T1DM adults attending outpatient units of a third-level hospital in Nigeria. Patients’ fasting plasma glucose and lipid parameters at the time of T1DM diagnosis were abstracted from their medical files. Lipid parameters included triglyceride (Tg), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C). Abstracted parameters were analyzed using descriptive and comparative statistics. Results: Of the 346 studied, 46.8% (n=162) were dyslipidemic (aged: 32.69±6.29) with female predominance (59.3%; p=0.018). Categorically, females predominated among isolated dyslipidemics while males predominated among the combined/mixed dyslipidemics. High plasma Tg concentration (n=142;87.7%) was the most common isolated dyslipidemia without male/female difference (p>0.05); seconded by low HDL-C (n=80;49.4%) with the females predominating (p<0.05). The most combined and mixed dyslipidemia was high plasma Tg/low HDL-C (total n=28, 17.3%; males n=16, 24.2% vs. females n=12, 12.5%; p=0.011) and high plasma Tg/high LDL-C/low-HDL-C (total n=30, 18.5%; males n=18, 27.3% vs. females n=12, 12.5%; p=0.001) concentrations, respectively with male predominance. The female dyslipidemics were younger with lower BMI, higher systolic blood pressure, glycemia, and mean plasma Tg levels (p<0.05). The overall dyslipidemics had poor glycemic status and their risk of dyslipidemia increases with worsening glycemia. Conclusion: Dyslipidemia was common and associated with poor glycemic status among the studied cohorts. This finding informs the need for more rigorous monitoring of dyslipidemia among T1DM subjects to reduce the risk of its complications.},
 year = {2020}
}

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TY  - JOUR
T1  - Lipid/Lipoprotein Abnormalities Among Adult Type 1 Diabetics in Nigeria
AU  - Collins Amadi
AU  - Olufisayo Gabriel Ayoade
AU  - Fabian Aniekpon Unyime
AU  - Sarah Ifreke Essien
AU  - Blessing Thomas Moses
AU  - Mfonobong Eni Enyong
Y1  - 2020/09/24
PY  - 2020
N1  - https://doi.org/10.11648/j.sjcm.20200903.16
DO  - 10.11648/j.sjcm.20200903.16
T2  - Science Journal of Clinical Medicine
JF  - Science Journal of Clinical Medicine
JO  - Science Journal of Clinical Medicine
SP  - 74
EP  - 81
PB  - Science Publishing Group
SN  - 2327-2732
UR  - https://doi.org/10.11648/j.sjcm.20200903.16
AB  - Background: Dyslipidemia abounds among diabetics. However, these are poorly characterized among patients with type 1 diabetes (T1DM). The current study determined the pattern of dyslipidemia and their relationship with glycemic status among adult T1DM subjects. Methods: This survey was conducted retrospectively among 346 newly-diagnosed/treatment-naïve T1DM adults attending outpatient units of a third-level hospital in Nigeria. Patients’ fasting plasma glucose and lipid parameters at the time of T1DM diagnosis were abstracted from their medical files. Lipid parameters included triglyceride (Tg), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C). Abstracted parameters were analyzed using descriptive and comparative statistics. Results: Of the 346 studied, 46.8% (n=162) were dyslipidemic (aged: 32.69±6.29) with female predominance (59.3%; p=0.018). Categorically, females predominated among isolated dyslipidemics while males predominated among the combined/mixed dyslipidemics. High plasma Tg concentration (n=142;87.7%) was the most common isolated dyslipidemia without male/female difference (p>0.05); seconded by low HDL-C (n=80;49.4%) with the females predominating (p<0.05). The most combined and mixed dyslipidemia was high plasma Tg/low HDL-C (total n=28, 17.3%; males n=16, 24.2% vs. females n=12, 12.5%; p=0.011) and high plasma Tg/high LDL-C/low-HDL-C (total n=30, 18.5%; males n=18, 27.3% vs. females n=12, 12.5%; p=0.001) concentrations, respectively with male predominance. The female dyslipidemics were younger with lower BMI, higher systolic blood pressure, glycemia, and mean plasma Tg levels (p<0.05). The overall dyslipidemics had poor glycemic status and their risk of dyslipidemia increases with worsening glycemia. Conclusion: Dyslipidemia was common and associated with poor glycemic status among the studied cohorts. This finding informs the need for more rigorous monitoring of dyslipidemia among T1DM subjects to reduce the risk of its complications.
VL  - 9
IS  - 3
ER  - 

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