Aetiologic Diagnosis and the Efficacy of Interventional Treatment of Intraluminal Central Airway Spheroid Masses

Wei Song; Wangjian Zha; Jiwang Wang

doi:doi:10.11648/j.sjcm.20200902.14

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Aetiologic Diagnosis and the Efficacy of Interventional Treatment of Intraluminal Central Airway Spheroid Masses

Wei Song, Wangjian Zha, Jiwang Wang

Published in Science Journal of Clinical Medicine (Volume 9, Issue 2)

Received: 14 May 2020 Accepted: 4 June 2020 Published: 17 June 2020

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Abstract

Objective To explore the diagnosis of, clinical characteristics of and effects of interventional therapy for intraluminal central airway spheroid masses. Methods Forty-four patients with intraluminal central airway spheroid masses were summarized retrospectively, and the clinical characteristics and therapy were analysed. Results Cough and shortness of breath were the predominant symptoms, followed by hemoptysis, fever and chest pain. The aetiologic diagnoses were 12 cases of inflammatory granulomas, 5 cases of foreign matter, 5 cases of squamous carcinoma, 4 cases of leiomyoma, 3 cases of lipomyoma, 2 cases of inflammatory myofibroblastic tumor, and one case each of glomus tumor, adenocarcinoma, mucoepidermoid carcinoma, malignant melanoma metastasis, carcinoid, adenoid cystic carcinoma, chondrosarcoma, combined small cell carcinoma, hamartoma, mixed tumor, neurilemmoma, acidophilic adenoma and salivary gland tumor. The numbers of masses located in the trachea, left main bronchus, right main bronchus and bronchus intermedius were 20, 13, 7, and 4, respectively. Electrocautery snare and electrocoagulation probe was the most commonly used interventional therapy method, followed by argon plasma coagulation and cryotherapy; stent implantation was used in 1 case. Thirty-five cases achieved a complete response or partial response after treatment, 8 cases achieved a mild response, and 1 had no response. Conclusion The symptoms of intraluminal central airway spheroid masses were atypical and easily misdiagnosed or missed; benign lesions were the leading cause, and the first pathological type was inflammatory granuloma. Endoscopic intervention was the effective, safe technique.

Published in	Science Journal of Clinical Medicine (Volume 9, Issue 2)
DOI	10.11648/j.sjcm.20200902.14
Page(s)	37-42
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Central Airway Obstruction, Bronchoscopes, Diagnosis, Interventional Therapy, Electrocautery

References

[1]	Wang J, Yang Y, Zha W, et al. The clinical feasibility of flexible bronchoscopy interventional therapy in patients with central airway stenosis and respiratory failure caused by malignancy. Onco Targets Ther. 2018; 11: 7709-7714.
[2]	Freitag L, Ernst A, Unger M, et al. A proposed classification system of central airway stenosis. Eur Respir J. 2007; 30: 7-12.
[3]	Reichle G, Freitag L, Kullmann HJ, et al. Argon plasma coagulation in bronchology: a new method--alternative or complementary? Pneumologie. 2005; 54: 508-516 (in German).
[4]	Barros Casas D, Fernández-Bussy S, Folch E, et al. Non-malignant central airway obstruction. Arch Bronconeumol. 2014; 50: 345-354.
[5]	Stevic R, Milenkovic B. Tracheobronchial tumors. J Thorac Dis. 2016; 8: 3401-3413.
[6]	Semaan R, Yarmus L. Rigid bronchoscopy and silicone stents in the management of central airway obstruction. J Thorac Dis. 2015; 7: S352-S362.
[7]	Karapantzos I, Karapantzou C, Zarogoulidis P, et al. Benign tracheal stenosis a case report and up to date management. Ann Transl Med. 2016; 4: 451.
[8]	Bolliger CT, Sutedja TG, Strausz J, et al. Therapeutic bronchoscopy with immediate effect: laser, electrocautery, argon plasma coagulation and stents. Eur Respir J. 2006; 27: 1258-1271.
[9]	DiBardino DM, Lanfranco AR, Haas AR. Bronchoscopic Cryotherapy. Clinical Applications of the Cryoprobe, Cryospray, and Cryoadhesion. Ann Am Thorac Soc. 2016; 13: 1405-1415.
[10]	Uskul BT, Baran R, Turan FE, et al. Endoscopic removal of a chondromatous hamartoma by bronchoscopic electrosurgical snare and argon plasma coagulation. Monaldi Arch Chest Dis. 2007; 67: 238-240.

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APA Style

Wei Song, Wangjian Zha, Jiwang Wang. (2020). Aetiologic Diagnosis and the Efficacy of Interventional Treatment of Intraluminal Central Airway Spheroid Masses. Science Journal of Clinical Medicine, 9(2), 37-42. https://doi.org/10.11648/j.sjcm.20200902.14

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ACS Style

Wei Song; Wangjian Zha; Jiwang Wang. Aetiologic Diagnosis and the Efficacy of Interventional Treatment of Intraluminal Central Airway Spheroid Masses. Sci. J. Clin. Med. 2020, 9(2), 37-42. doi: 10.11648/j.sjcm.20200902.14

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AMA Style

Wei Song, Wangjian Zha, Jiwang Wang. Aetiologic Diagnosis and the Efficacy of Interventional Treatment of Intraluminal Central Airway Spheroid Masses. Sci J Clin Med. 2020;9(2):37-42. doi: 10.11648/j.sjcm.20200902.14

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@article{10.11648/j.sjcm.20200902.14,
  author = {Wei Song and Wangjian Zha and Jiwang Wang},
  title = {Aetiologic Diagnosis and the Efficacy of Interventional Treatment of Intraluminal Central Airway Spheroid Masses},
  journal = {Science Journal of Clinical Medicine},
  volume = {9},
  number = {2},
  pages = {37-42},
  doi = {10.11648/j.sjcm.20200902.14},
  url = {https://doi.org/10.11648/j.sjcm.20200902.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjcm.20200902.14},
  abstract = {Objective To explore the diagnosis of, clinical characteristics of and effects of interventional therapy for intraluminal central airway spheroid masses. Methods Forty-four patients with intraluminal central airway spheroid masses were summarized retrospectively, and the clinical characteristics and therapy were analysed. Results Cough and shortness of breath were the predominant symptoms, followed by hemoptysis, fever and chest pain. The aetiologic diagnoses were 12 cases of inflammatory granulomas, 5 cases of foreign matter, 5 cases of squamous carcinoma, 4 cases of leiomyoma, 3 cases of lipomyoma, 2 cases of inflammatory myofibroblastic tumor, and one case each of glomus tumor, adenocarcinoma, mucoepidermoid carcinoma, malignant melanoma metastasis, carcinoid, adenoid cystic carcinoma, chondrosarcoma, combined small cell carcinoma, hamartoma, mixed tumor, neurilemmoma, acidophilic adenoma and salivary gland tumor. The numbers of masses located in the trachea, left main bronchus, right main bronchus and bronchus intermedius were 20, 13, 7, and 4, respectively. Electrocautery snare and electrocoagulation probe was the most commonly used interventional therapy method, followed by argon plasma coagulation and cryotherapy; stent implantation was used in 1 case. Thirty-five cases achieved a complete response or partial response after treatment, 8 cases achieved a mild response, and 1 had no response. Conclusion The symptoms of intraluminal central airway spheroid masses were atypical and easily misdiagnosed or missed; benign lesions were the leading cause, and the first pathological type was inflammatory granuloma. Endoscopic intervention was the effective, safe technique.},
 year = {2020}
}

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TY  - JOUR
T1  - Aetiologic Diagnosis and the Efficacy of Interventional Treatment of Intraluminal Central Airway Spheroid Masses
AU  - Wei Song
AU  - Wangjian Zha
AU  - Jiwang Wang
Y1  - 2020/06/17
PY  - 2020
N1  - https://doi.org/10.11648/j.sjcm.20200902.14
DO  - 10.11648/j.sjcm.20200902.14
T2  - Science Journal of Clinical Medicine
JF  - Science Journal of Clinical Medicine
JO  - Science Journal of Clinical Medicine
SP  - 37
EP  - 42
PB  - Science Publishing Group
SN  - 2327-2732
UR  - https://doi.org/10.11648/j.sjcm.20200902.14
AB  - Objective To explore the diagnosis of, clinical characteristics of and effects of interventional therapy for intraluminal central airway spheroid masses. Methods Forty-four patients with intraluminal central airway spheroid masses were summarized retrospectively, and the clinical characteristics and therapy were analysed. Results Cough and shortness of breath were the predominant symptoms, followed by hemoptysis, fever and chest pain. The aetiologic diagnoses were 12 cases of inflammatory granulomas, 5 cases of foreign matter, 5 cases of squamous carcinoma, 4 cases of leiomyoma, 3 cases of lipomyoma, 2 cases of inflammatory myofibroblastic tumor, and one case each of glomus tumor, adenocarcinoma, mucoepidermoid carcinoma, malignant melanoma metastasis, carcinoid, adenoid cystic carcinoma, chondrosarcoma, combined small cell carcinoma, hamartoma, mixed tumor, neurilemmoma, acidophilic adenoma and salivary gland tumor. The numbers of masses located in the trachea, left main bronchus, right main bronchus and bronchus intermedius were 20, 13, 7, and 4, respectively. Electrocautery snare and electrocoagulation probe was the most commonly used interventional therapy method, followed by argon plasma coagulation and cryotherapy; stent implantation was used in 1 case. Thirty-five cases achieved a complete response or partial response after treatment, 8 cases achieved a mild response, and 1 had no response. Conclusion The symptoms of intraluminal central airway spheroid masses were atypical and easily misdiagnosed or missed; benign lesions were the leading cause, and the first pathological type was inflammatory granuloma. Endoscopic intervention was the effective, safe technique.
VL  - 9
IS  - 2
ER  -

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Author Information

Wei Song

Department of Pulmonary and Critical Care Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China
Wangjian Zha

Department of Pulmonary and Critical Care Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China
Jiwang Wang

Department of Pulmonary and Critical Care Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China

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APA Style

Wei Song, Wangjian Zha, Jiwang Wang. (2020). Aetiologic Diagnosis and the Efficacy of Interventional Treatment of Intraluminal Central Airway Spheroid Masses. Science Journal of Clinical Medicine, 9(2), 37-42. https://doi.org/10.11648/j.sjcm.20200902.14

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ACS Style

Wei Song; Wangjian Zha; Jiwang Wang. Aetiologic Diagnosis and the Efficacy of Interventional Treatment of Intraluminal Central Airway Spheroid Masses. Sci. J. Clin. Med. 2020, 9(2), 37-42. doi: 10.11648/j.sjcm.20200902.14

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AMA Style

Wei Song, Wangjian Zha, Jiwang Wang. Aetiologic Diagnosis and the Efficacy of Interventional Treatment of Intraluminal Central Airway Spheroid Masses. Sci J Clin Med. 2020;9(2):37-42. doi: 10.11648/j.sjcm.20200902.14

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@article{10.11648/j.sjcm.20200902.14,
  author = {Wei Song and Wangjian Zha and Jiwang Wang},
  title = {Aetiologic Diagnosis and the Efficacy of Interventional Treatment of Intraluminal Central Airway Spheroid Masses},
  journal = {Science Journal of Clinical Medicine},
  volume = {9},
  number = {2},
  pages = {37-42},
  doi = {10.11648/j.sjcm.20200902.14},
  url = {https://doi.org/10.11648/j.sjcm.20200902.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjcm.20200902.14},
  abstract = {Objective To explore the diagnosis of, clinical characteristics of and effects of interventional therapy for intraluminal central airway spheroid masses. Methods Forty-four patients with intraluminal central airway spheroid masses were summarized retrospectively, and the clinical characteristics and therapy were analysed. Results Cough and shortness of breath were the predominant symptoms, followed by hemoptysis, fever and chest pain. The aetiologic diagnoses were 12 cases of inflammatory granulomas, 5 cases of foreign matter, 5 cases of squamous carcinoma, 4 cases of leiomyoma, 3 cases of lipomyoma, 2 cases of inflammatory myofibroblastic tumor, and one case each of glomus tumor, adenocarcinoma, mucoepidermoid carcinoma, malignant melanoma metastasis, carcinoid, adenoid cystic carcinoma, chondrosarcoma, combined small cell carcinoma, hamartoma, mixed tumor, neurilemmoma, acidophilic adenoma and salivary gland tumor. The numbers of masses located in the trachea, left main bronchus, right main bronchus and bronchus intermedius were 20, 13, 7, and 4, respectively. Electrocautery snare and electrocoagulation probe was the most commonly used interventional therapy method, followed by argon plasma coagulation and cryotherapy; stent implantation was used in 1 case. Thirty-five cases achieved a complete response or partial response after treatment, 8 cases achieved a mild response, and 1 had no response. Conclusion The symptoms of intraluminal central airway spheroid masses were atypical and easily misdiagnosed or missed; benign lesions were the leading cause, and the first pathological type was inflammatory granuloma. Endoscopic intervention was the effective, safe technique.},
 year = {2020}
}

Copy | Download

TY  - JOUR
T1  - Aetiologic Diagnosis and the Efficacy of Interventional Treatment of Intraluminal Central Airway Spheroid Masses
AU  - Wei Song
AU  - Wangjian Zha
AU  - Jiwang Wang
Y1  - 2020/06/17
PY  - 2020
N1  - https://doi.org/10.11648/j.sjcm.20200902.14
DO  - 10.11648/j.sjcm.20200902.14
T2  - Science Journal of Clinical Medicine
JF  - Science Journal of Clinical Medicine
JO  - Science Journal of Clinical Medicine
SP  - 37
EP  - 42
PB  - Science Publishing Group
SN  - 2327-2732
UR  - https://doi.org/10.11648/j.sjcm.20200902.14
AB  - Objective To explore the diagnosis of, clinical characteristics of and effects of interventional therapy for intraluminal central airway spheroid masses. Methods Forty-four patients with intraluminal central airway spheroid masses were summarized retrospectively, and the clinical characteristics and therapy were analysed. Results Cough and shortness of breath were the predominant symptoms, followed by hemoptysis, fever and chest pain. The aetiologic diagnoses were 12 cases of inflammatory granulomas, 5 cases of foreign matter, 5 cases of squamous carcinoma, 4 cases of leiomyoma, 3 cases of lipomyoma, 2 cases of inflammatory myofibroblastic tumor, and one case each of glomus tumor, adenocarcinoma, mucoepidermoid carcinoma, malignant melanoma metastasis, carcinoid, adenoid cystic carcinoma, chondrosarcoma, combined small cell carcinoma, hamartoma, mixed tumor, neurilemmoma, acidophilic adenoma and salivary gland tumor. The numbers of masses located in the trachea, left main bronchus, right main bronchus and bronchus intermedius were 20, 13, 7, and 4, respectively. Electrocautery snare and electrocoagulation probe was the most commonly used interventional therapy method, followed by argon plasma coagulation and cryotherapy; stent implantation was used in 1 case. Thirty-five cases achieved a complete response or partial response after treatment, 8 cases achieved a mild response, and 1 had no response. Conclusion The symptoms of intraluminal central airway spheroid masses were atypical and easily misdiagnosed or missed; benign lesions were the leading cause, and the first pathological type was inflammatory granuloma. Endoscopic intervention was the effective, safe technique.
VL  - 9
IS  - 2
ER  -

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