Anaerobic glycolysis advertise the production of energy under hypoxic condition (absence of oxygen), while in aerobic glycolysis, the Warburg effect gives a momentous benefit through remodeling carbohydrates seeds from production of energy to biochemical pathways. On the other side, high degree of lactate have been cooperated with feeble outcome in human tumors as well as glycolytic switch is correlated with high rate of glucose uptake and lactate production. Although lactic acid was primarily remind as indicator of the glycolytic process in which many mechanisms initiates from the study of normal tissue physiology and transported to the tumor indicating lactic acid in essence lactate anion and protons, straightly contributes to tumor growth and development. MCT1 & MCT4 monocarboxylate transporters have been justified as well-known facilitators of lactate exchanges between various cancer cells with many metabolic behaviors. In this review, we summarize the current knowledge on the role of lactic acidosis and metastasis, lactate shuttles and lactate signaling molecules.
| Published in | Science Journal of Clinical Medicine (Volume 9, Issue 1) |
| DOI | 10.11648/j.sjcm.20200901.11 |
| Page(s) | 1-6 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2020. Published by Science Publishing Group |
Lactic Acid, Tumor Intrusion, Shuttles, Signaling Molecules
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APA Style
Sameer Sharma, Rajan Chourasiya, Shahna T, Gaddam Roopa Shivani. (2020). Role of Lactic Acid in Cancer Metabolism Under the Influences on Tumor Expansion and Metamorphosis: A Review. Science Journal of Clinical Medicine, 9(1), 1-6. https://doi.org/10.11648/j.sjcm.20200901.11
ACS Style
Sameer Sharma; Rajan Chourasiya; Shahna T; Gaddam Roopa Shivani. Role of Lactic Acid in Cancer Metabolism Under the Influences on Tumor Expansion and Metamorphosis: A Review. Sci. J. Clin. Med. 2020, 9(1), 1-6. doi: 10.11648/j.sjcm.20200901.11
AMA Style
Sameer Sharma, Rajan Chourasiya, Shahna T, Gaddam Roopa Shivani. Role of Lactic Acid in Cancer Metabolism Under the Influences on Tumor Expansion and Metamorphosis: A Review. Sci J Clin Med. 2020;9(1):1-6. doi: 10.11648/j.sjcm.20200901.11
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Download@article{10.11648/j.sjcm.20200901.11,
author = {Sameer Sharma and Rajan Chourasiya and Shahna T and Gaddam Roopa Shivani},
title = {Role of Lactic Acid in Cancer Metabolism Under the Influences on Tumor Expansion and Metamorphosis: A Review},
journal = {Science Journal of Clinical Medicine},
volume = {9},
number = {1},
pages = {1-6},
doi = {10.11648/j.sjcm.20200901.11},
url = {https://doi.org/10.11648/j.sjcm.20200901.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjcm.20200901.11},
abstract = {Anaerobic glycolysis advertise the production of energy under hypoxic condition (absence of oxygen), while in aerobic glycolysis, the Warburg effect gives a momentous benefit through remodeling carbohydrates seeds from production of energy to biochemical pathways. On the other side, high degree of lactate have been cooperated with feeble outcome in human tumors as well as glycolytic switch is correlated with high rate of glucose uptake and lactate production. Although lactic acid was primarily remind as indicator of the glycolytic process in which many mechanisms initiates from the study of normal tissue physiology and transported to the tumor indicating lactic acid in essence lactate anion and protons, straightly contributes to tumor growth and development. MCT1 & MCT4 monocarboxylate transporters have been justified as well-known facilitators of lactate exchanges between various cancer cells with many metabolic behaviors. In this review, we summarize the current knowledge on the role of lactic acidosis and metastasis, lactate shuttles and lactate signaling molecules.},
year = {2020}
}
TY - JOUR T1 - Role of Lactic Acid in Cancer Metabolism Under the Influences on Tumor Expansion and Metamorphosis: A Review AU - Sameer Sharma AU - Rajan Chourasiya AU - Shahna T AU - Gaddam Roopa Shivani Y1 - 2020/01/10 PY - 2020 N1 - https://doi.org/10.11648/j.sjcm.20200901.11 DO - 10.11648/j.sjcm.20200901.11 T2 - Science Journal of Clinical Medicine JF - Science Journal of Clinical Medicine JO - Science Journal of Clinical Medicine SP - 1 EP - 6 PB - Science Publishing Group SN - 2327-2732 UR - https://doi.org/10.11648/j.sjcm.20200901.11 AB - Anaerobic glycolysis advertise the production of energy under hypoxic condition (absence of oxygen), while in aerobic glycolysis, the Warburg effect gives a momentous benefit through remodeling carbohydrates seeds from production of energy to biochemical pathways. On the other side, high degree of lactate have been cooperated with feeble outcome in human tumors as well as glycolytic switch is correlated with high rate of glucose uptake and lactate production. Although lactic acid was primarily remind as indicator of the glycolytic process in which many mechanisms initiates from the study of normal tissue physiology and transported to the tumor indicating lactic acid in essence lactate anion and protons, straightly contributes to tumor growth and development. MCT1 & MCT4 monocarboxylate transporters have been justified as well-known facilitators of lactate exchanges between various cancer cells with many metabolic behaviors. In this review, we summarize the current knowledge on the role of lactic acidosis and metastasis, lactate shuttles and lactate signaling molecules. VL - 9 IS - 1 ER -
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