The Accuracy of <i>Kidney Injury Molecule-</i> 1 for Earlier Diagnosis Acute Kidney Injury in Polytrauma

Tinni Trihartini Maskoen; Budiana Rismawan; Rangga Saputra

doi:doi:10.11648/j.sjcm.20190805.11

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The Accuracy of Kidney Injury Molecule- 1 for Earlier Diagnosis Acute Kidney Injury in Polytrauma

Tinni Trihartini Maskoen, Budiana Rismawan, Rangga Saputra

Published in Science Journal of Clinical Medicine (Volume 8, Issue 5)

Received: 22 July 2019 Accepted: 28 August 2019 Published: 17 September 2019

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Abstract

Multiple trauma often causes acute kidney injury (AKI) and is one of the most common causes of death in the world. Multiple trauma is a severe injury to an organ that is followed or accompanied by injury to other organs with injury severity score ≥ 16 causing hypovolume, hypoxia, and the release of inflammatory mediators which may lead to AKI. The diagnosis of AKI has been carried out using serum creatinine but this examination has many shortcomings, especially in terms of the time of increase in serum creatinine and much influenced by other factors. New biomarkers are expected to have an advantage over serum creatinine, namely kidney injury molecule-1 (KIM-1). This study aims to determine the area under curve (AUC) and the accuracy of KIM-1 for the diagnosis of AKI in polytrauma. This study carried out a diagnostic test using secondary data with a cross sectional design of all secondary data of the study. This study took secondary data from patients with multiple trauma at the emergency room at RSUP Dr. Hasan Sadikin Bandung from January - June 2017, which is the academic leadership grant (ALG) research data. Data was processed by diagnostic tests, and analyzed by receiver operating characteristic (ROC) curves. KIM-1 has a 109.7 ng / mL cut-off point, sensitivity of 100%, specificity of 88.89%, positive predictive value of 71.4%, negative predictive value of 100%, AUC value of 0.857 and accuracy of 91.3%. The conclusion of this study is that biomarkers of KIM-1 have an AUC value and a good value of accuracy so that it can be used to diagnose AKI more accurately.

Published in	Science Journal of Clinical Medicine (Volume 8, Issue 5)
DOI	10.11648/j.sjcm.20190805.11
Page(s)	49-53
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Acute Kidney Injury, Multiple Trauma, Creatinine, Kidney Injury Molecule–1

References

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[7]	Sabbisetti VS, Waikar SS, Antoine DJ, Smiles A, Wang C. Blood kidney injury molecule-1 is a biomarker of acute and chronic kidney injury and predicts progression to ESRD in type I diabetes. J Am Soc Nephrol. 2014; 25 (10): 2177-86.
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APA Style

Tinni Trihartini Maskoen, Budiana Rismawan, Rangga Saputra. (2019). The Accuracy of Kidney Injury Molecule- 1 for Earlier Diagnosis Acute Kidney Injury in Polytrauma. Science Journal of Clinical Medicine, 8(5), 49-53. https://doi.org/10.11648/j.sjcm.20190805.11

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ACS Style

Tinni Trihartini Maskoen; Budiana Rismawan; Rangga Saputra. The Accuracy of Kidney Injury Molecule- 1 for Earlier Diagnosis Acute Kidney Injury in Polytrauma. Sci. J. Clin. Med. 2019, 8(5), 49-53. doi: 10.11648/j.sjcm.20190805.11

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AMA Style

Tinni Trihartini Maskoen, Budiana Rismawan, Rangga Saputra. The Accuracy of Kidney Injury Molecule- 1 for Earlier Diagnosis Acute Kidney Injury in Polytrauma. Sci J Clin Med. 2019;8(5):49-53. doi: 10.11648/j.sjcm.20190805.11

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@article{10.11648/j.sjcm.20190805.11,
  author = {Tinni Trihartini Maskoen and Budiana Rismawan and Rangga Saputra},
  title = {The Accuracy of Kidney Injury Molecule- 1 for Earlier Diagnosis Acute Kidney Injury in Polytrauma},
  journal = {Science Journal of Clinical Medicine},
  volume = {8},
  number = {5},
  pages = {49-53},
  doi = {10.11648/j.sjcm.20190805.11},
  url = {https://doi.org/10.11648/j.sjcm.20190805.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjcm.20190805.11},
  abstract = {Multiple trauma often causes acute kidney injury (AKI) and is one of the most common causes of death in the world. Multiple trauma is a severe injury to an organ that is followed or accompanied by injury to other organs with injury severity score ≥ 16 causing hypovolume, hypoxia, and the release of inflammatory mediators which may lead to AKI. The diagnosis of AKI has been carried out using serum creatinine but this examination has many shortcomings, especially in terms of the time of increase in serum creatinine and much influenced by other factors. New biomarkers are expected to have an advantage over serum creatinine, namely kidney injury molecule-1 (KIM-1). This study aims to determine the area under curve (AUC) and the accuracy of KIM-1 for the diagnosis of AKI in polytrauma. This study carried out a diagnostic test using secondary data with a cross sectional design of all secondary data of the study. This study took secondary data from patients with multiple trauma at the emergency room at RSUP Dr. Hasan Sadikin Bandung from January - June 2017, which is the academic leadership grant (ALG) research data. Data was processed by diagnostic tests, and analyzed by receiver operating characteristic (ROC) curves. KIM-1 has a 109.7 ng / mL cut-off point, sensitivity of 100%, specificity of 88.89%, positive predictive value of 71.4%, negative predictive value of 100%, AUC value of 0.857 and accuracy of 91.3%. The conclusion of this study is that biomarkers of KIM-1 have an AUC value and a good value of accuracy so that it can be used to diagnose AKI more accurately.},
 year = {2019}
}

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TY - JOUR
T1 - The Accuracy of Kidney Injury Molecule- 1 for Earlier Diagnosis Acute Kidney Injury in Polytrauma
AU - Tinni Trihartini Maskoen
AU - Budiana Rismawan
AU - Rangga Saputra
Y1 - 2019/09/17
PY - 2019
N1 - https://doi.org/10.11648/j.sjcm.20190805.11
DO - 10.11648/j.sjcm.20190805.11
T2 - Science Journal of Clinical Medicine
JF - Science Journal of Clinical Medicine
JO - Science Journal of Clinical Medicine
SP - 49
EP - 53
PB - Science Publishing Group
SN - 2327-2732
UR - https://doi.org/10.11648/j.sjcm.20190805.11
AB - Multiple trauma often causes acute kidney injury (AKI) and is one of the most common causes of death in the world. Multiple trauma is a severe injury to an organ that is followed or accompanied by injury to other organs with injury severity score ≥ 16 causing hypovolume, hypoxia, and the release of inflammatory mediators which may lead to AKI. The diagnosis of AKI has been carried out using serum creatinine but this examination has many shortcomings, especially in terms of the time of increase in serum creatinine and much influenced by other factors. New biomarkers are expected to have an advantage over serum creatinine, namely kidney injury molecule-1 (KIM-1). This study aims to determine the area under curve (AUC) and the accuracy of KIM-1 for the diagnosis of AKI in polytrauma. This study carried out a diagnostic test using secondary data with a cross sectional design of all secondary data of the study. This study took secondary data from patients with multiple trauma at the emergency room at RSUP Dr. Hasan Sadikin Bandung from January - June 2017, which is the academic leadership grant (ALG) research data. Data was processed by diagnostic tests, and analyzed by receiver operating characteristic (ROC) curves. KIM-1 has a 109.7 ng / mL cut-off point, sensitivity of 100%, specificity of 88.89%, positive predictive value of 71.4%, negative predictive value of 100%, AUC value of 0.857 and accuracy of 91.3%. The conclusion of this study is that biomarkers of KIM-1 have an AUC value and a good value of accuracy so that it can be used to diagnose AKI more accurately.
VL - 8
IS - 5
ER -

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Author Information

Tinni Trihartini Maskoen

Department of Anesthesiology and Intensive Therapy, Faculty of Medicine Universitas Padjadjaran, Dr. Hasan Sadikin Hospital, Bandung, West Java, Indonesia
Budiana Rismawan

Department of Anesthesiology and Intensive Therapy, Faculty of Medicine Universitas Padjadjaran, Dr. Hasan Sadikin Hospital, Bandung, West Java, Indonesia
Rangga Saputra

Department of Anesthesiology and Intensive Therapy, Faculty of Medicine Universitas Padjadjaran, Dr. Hasan Sadikin Hospital, Bandung, West Java, Indonesia

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APA Style

Tinni Trihartini Maskoen, Budiana Rismawan, Rangga Saputra. (2019). The Accuracy of Kidney Injury Molecule- 1 for Earlier Diagnosis Acute Kidney Injury in Polytrauma. Science Journal of Clinical Medicine, 8(5), 49-53. https://doi.org/10.11648/j.sjcm.20190805.11

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ACS Style

Tinni Trihartini Maskoen; Budiana Rismawan; Rangga Saputra. The Accuracy of Kidney Injury Molecule- 1 for Earlier Diagnosis Acute Kidney Injury in Polytrauma. Sci. J. Clin. Med. 2019, 8(5), 49-53. doi: 10.11648/j.sjcm.20190805.11

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AMA Style

Tinni Trihartini Maskoen, Budiana Rismawan, Rangga Saputra. The Accuracy of Kidney Injury Molecule- 1 for Earlier Diagnosis Acute Kidney Injury in Polytrauma. Sci J Clin Med. 2019;8(5):49-53. doi: 10.11648/j.sjcm.20190805.11

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@article{10.11648/j.sjcm.20190805.11,
  author = {Tinni Trihartini Maskoen and Budiana Rismawan and Rangga Saputra},
  title = {The Accuracy of Kidney Injury Molecule- 1 for Earlier Diagnosis Acute Kidney Injury in Polytrauma},
  journal = {Science Journal of Clinical Medicine},
  volume = {8},
  number = {5},
  pages = {49-53},
  doi = {10.11648/j.sjcm.20190805.11},
  url = {https://doi.org/10.11648/j.sjcm.20190805.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjcm.20190805.11},
  abstract = {Multiple trauma often causes acute kidney injury (AKI) and is one of the most common causes of death in the world. Multiple trauma is a severe injury to an organ that is followed or accompanied by injury to other organs with injury severity score ≥ 16 causing hypovolume, hypoxia, and the release of inflammatory mediators which may lead to AKI. The diagnosis of AKI has been carried out using serum creatinine but this examination has many shortcomings, especially in terms of the time of increase in serum creatinine and much influenced by other factors. New biomarkers are expected to have an advantage over serum creatinine, namely kidney injury molecule-1 (KIM-1). This study aims to determine the area under curve (AUC) and the accuracy of KIM-1 for the diagnosis of AKI in polytrauma. This study carried out a diagnostic test using secondary data with a cross sectional design of all secondary data of the study. This study took secondary data from patients with multiple trauma at the emergency room at RSUP Dr. Hasan Sadikin Bandung from January - June 2017, which is the academic leadership grant (ALG) research data. Data was processed by diagnostic tests, and analyzed by receiver operating characteristic (ROC) curves. KIM-1 has a 109.7 ng / mL cut-off point, sensitivity of 100%, specificity of 88.89%, positive predictive value of 71.4%, negative predictive value of 100%, AUC value of 0.857 and accuracy of 91.3%. The conclusion of this study is that biomarkers of KIM-1 have an AUC value and a good value of accuracy so that it can be used to diagnose AKI more accurately.},
 year = {2019}
}

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