Risk Factors For Hepatitis B Virus Infection Among Adult Nigerians With Clinical Features Of Liver Diseases In A Resource-Constrained Environment Of A Primary Care Clinic In Eastern Nigeria

Gabriel Uche Pascal Iloh; Abali Chuku; Agwu Nkwa Amadi; Nnadozie Paul Obiegbu

doi:doi:10.11648/j.sjcm.20130203.17

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Risk Factors For Hepatitis B Virus Infection Among Adult Nigerians With Clinical Features Of Liver Diseases In A Resource-Constrained Environment Of A Primary Care Clinic In Eastern Nigeria

Gabriel Uche Pascal Iloh, Abali Chuku, Agwu Nkwa Amadi, Nnadozie Paul Obiegbu

Published in Science Journal of Clinical Medicine (Volume 2, Issue 3)

Received: 22 May 2013 Published: 20 June 2013

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Abstract

Background: Hepatitis B virus (HBV) infection is an important contributor to the burden of liver diseases in adult Nigerians and constitutes a threat to socio-economic development in the sub-region. Screening for its risk factors in patients with clinical features of liver diseases is an important primary care challenge that is often neglected. Aim: To determine the risk factors for HBV infection in adult Nigerians with clinical features of liver diseases in a resource-constrained environment of a primary care clinic in Eastern Nigeria. Materials and Methods: A cross sectional study was carried out on 140 adult Nigerians with clinical features of liver diseases at the primary care clinic of a tertiary hospital in Nigeria. Clinical features of liver diseases were based on the presence of some constitutional, hepatic and extra-hepatic features. Hepatitis B surface antigen (HBsAg) was assayed using immunochromatographic method. A pre-tested, structured interviewer-administered questionnaire was used to obtain socio-demographic variables and histories of HBV-related risk factors. Results: The HBV sero-prevalence was 50.7%. The age group 40 – 60 years (P=0.048) and artisans (P=0.019) were significantly infected. The behavioural risk factors significantly associated with HBV infection were histories of unprotected sexual exposures (P=0.001), blood transfusion (P=0.022) and non-hepatitis B vaccination (P=0.030). The most significant predictor of HBV infection was history of unprotected sexual exposures (OR=5.04, P=0.003). Conclusion: Risk factors of HBV infection exist in adult Nigerian patients with clinical features of liver diseases and HBV infection was significantly associated with age, occupation, unprotected sexual exposures, blood transfusion and non-hepatitis B vaccination.

Published in	Science Journal of Clinical Medicine (Volume 2, Issue 3)
DOI	10.11648/j.sjcm.20130203.17
Page(s)	98-105
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2013. Published by Science Publishing Group

Keywords

Hepatitis B Surface Antigen Sero-Marker, Liver Diseases, Nigeria, Primary Care Clinic, Risk Factors

References

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APA Style

Gabriel Uche Pascal Iloh, Abali Chuku, Agwu Nkwa Amadi, Nnadozie Paul Obiegbu. (2013). Risk Factors For Hepatitis B Virus Infection Among Adult Nigerians With Clinical Features Of Liver Diseases In A Resource-Constrained Environment Of A Primary Care Clinic In Eastern Nigeria. Science Journal of Clinical Medicine, 2(3), 98-105. https://doi.org/10.11648/j.sjcm.20130203.17

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ACS Style

Gabriel Uche Pascal Iloh; Abali Chuku; Agwu Nkwa Amadi; Nnadozie Paul Obiegbu. Risk Factors For Hepatitis B Virus Infection Among Adult Nigerians With Clinical Features Of Liver Diseases In A Resource-Constrained Environment Of A Primary Care Clinic In Eastern Nigeria. Sci. J. Clin. Med. 2013, 2(3), 98-105. doi: 10.11648/j.sjcm.20130203.17

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AMA Style

Gabriel Uche Pascal Iloh, Abali Chuku, Agwu Nkwa Amadi, Nnadozie Paul Obiegbu. Risk Factors For Hepatitis B Virus Infection Among Adult Nigerians With Clinical Features Of Liver Diseases In A Resource-Constrained Environment Of A Primary Care Clinic In Eastern Nigeria. Sci J Clin Med. 2013;2(3):98-105. doi: 10.11648/j.sjcm.20130203.17

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@article{10.11648/j.sjcm.20130203.17,
  author = {Gabriel Uche Pascal Iloh and Abali Chuku and Agwu Nkwa Amadi and Nnadozie Paul Obiegbu},
  title = {Risk Factors For Hepatitis B Virus Infection Among Adult Nigerians With Clinical Features Of Liver Diseases In A Resource-Constrained Environment Of A Primary Care Clinic In Eastern Nigeria},
  journal = {Science Journal of Clinical Medicine},
  volume = {2},
  number = {3},
  pages = {98-105},
  doi = {10.11648/j.sjcm.20130203.17},
  url = {https://doi.org/10.11648/j.sjcm.20130203.17},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjcm.20130203.17},
  abstract = {Background: Hepatitis B virus (HBV) infection is an important contributor to the burden of liver diseases in adult Nigerians and constitutes a threat to socio-economic development in the sub-region. Screening for its risk factors in patients with clinical features of liver diseases is an important primary care challenge that is often neglected. Aim: To determine the risk factors for HBV infection in adult Nigerians with clinical features of liver diseases in a resource-constrained environment of a primary care clinic in Eastern Nigeria. Materials and Methods: A cross sectional study was carried out on 140 adult Nigerians with clinical features of liver diseases at the primary care clinic of a tertiary hospital in Nigeria. Clinical features of liver diseases were based on the presence of some constitutional, hepatic and extra-hepatic features. Hepatitis B surface antigen (HBsAg) was assayed using immunochromatographic method. A pre-tested, structured interviewer-administered questionnaire was used to obtain socio-demographic variables and histories of HBV-related risk factors. Results: The HBV sero-prevalence was 50.7%. The age group 40 – 60 years (P=0.048) and artisans (P=0.019) were significantly infected. The behavioural risk factors significantly associated with HBV infection were histories of unprotected sexual exposures (P=0.001), blood transfusion (P=0.022) and non-hepatitis B vaccination (P=0.030). The most significant predictor of HBV infection was history of unprotected sexual exposures (OR=5.04, P=0.003). Conclusion: Risk factors of HBV infection exist in adult Nigerian patients with clinical features of liver diseases and HBV infection was significantly associated with age, occupation, unprotected sexual exposures, blood transfusion and non-hepatitis B vaccination.},
 year = {2013}
}

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TY  - JOUR
T1  - Risk Factors For Hepatitis B Virus Infection Among Adult Nigerians With Clinical Features Of Liver Diseases In A Resource-Constrained Environment Of A Primary Care Clinic In Eastern Nigeria
AU  - Gabriel Uche Pascal Iloh
AU  - Abali Chuku
AU  - Agwu Nkwa Amadi
AU  - Nnadozie Paul Obiegbu
Y1  - 2013/06/20
PY  - 2013
N1  - https://doi.org/10.11648/j.sjcm.20130203.17
DO  - 10.11648/j.sjcm.20130203.17
T2  - Science Journal of Clinical Medicine
JF  - Science Journal of Clinical Medicine
JO  - Science Journal of Clinical Medicine
SP  - 98
EP  - 105
PB  - Science Publishing Group
SN  - 2327-2732
UR  - https://doi.org/10.11648/j.sjcm.20130203.17
AB  - Background: Hepatitis B virus (HBV) infection is an important contributor to the burden of liver diseases in adult Nigerians and constitutes a threat to socio-economic development in the sub-region. Screening for its risk factors in patients with clinical features of liver diseases is an important primary care challenge that is often neglected. Aim: To determine the risk factors for HBV infection in adult Nigerians with clinical features of liver diseases in a resource-constrained environment of a primary care clinic in Eastern Nigeria. Materials and Methods: A cross sectional study was carried out on 140 adult Nigerians with clinical features of liver diseases at the primary care clinic of a tertiary hospital in Nigeria. Clinical features of liver diseases were based on the presence of some constitutional, hepatic and extra-hepatic features. Hepatitis B surface antigen (HBsAg) was assayed using immunochromatographic method. A pre-tested, structured interviewer-administered questionnaire was used to obtain socio-demographic variables and histories of HBV-related risk factors. Results: The HBV sero-prevalence was 50.7%. The age group 40 – 60 years (P=0.048) and artisans (P=0.019) were significantly infected. The behavioural risk factors significantly associated with HBV infection were histories of unprotected sexual exposures (P=0.001), blood transfusion (P=0.022) and non-hepatitis B vaccination (P=0.030). The most significant predictor of HBV infection was history of unprotected sexual exposures (OR=5.04, P=0.003). Conclusion: Risk factors of HBV infection exist in adult Nigerian patients with clinical features of liver diseases and HBV infection was significantly associated with age, occupation, unprotected sexual exposures, blood transfusion and non-hepatitis B vaccination.
VL  - 2
IS  - 3
ER  -

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Author Information

Gabriel Uche Pascal Iloh

Department of Family Medicine, Federal Medical Centre, Umuahia, Abia state, Nigeria
Abali Chuku

Department of Ophthalmology Federal Medical Centre, Umuahia, Abia state, Nigeria
Agwu Nkwa Amadi

Department of Public Health Technology, Federal University of Technology, Owerri, Imo state, Nigeria
Nnadozie Paul Obiegbu

Ministry of Health, Awka, Anambra State, Nigeria and Trainer in Family Medicine program, Federal Medical Centre, Owerri, Nigeria

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APA Style

Gabriel Uche Pascal Iloh, Abali Chuku, Agwu Nkwa Amadi, Nnadozie Paul Obiegbu. (2013). Risk Factors For Hepatitis B Virus Infection Among Adult Nigerians With Clinical Features Of Liver Diseases In A Resource-Constrained Environment Of A Primary Care Clinic In Eastern Nigeria. Science Journal of Clinical Medicine, 2(3), 98-105. https://doi.org/10.11648/j.sjcm.20130203.17

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ACS Style

Gabriel Uche Pascal Iloh; Abali Chuku; Agwu Nkwa Amadi; Nnadozie Paul Obiegbu. Risk Factors For Hepatitis B Virus Infection Among Adult Nigerians With Clinical Features Of Liver Diseases In A Resource-Constrained Environment Of A Primary Care Clinic In Eastern Nigeria. Sci. J. Clin. Med. 2013, 2(3), 98-105. doi: 10.11648/j.sjcm.20130203.17

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AMA Style

Gabriel Uche Pascal Iloh, Abali Chuku, Agwu Nkwa Amadi, Nnadozie Paul Obiegbu. Risk Factors For Hepatitis B Virus Infection Among Adult Nigerians With Clinical Features Of Liver Diseases In A Resource-Constrained Environment Of A Primary Care Clinic In Eastern Nigeria. Sci J Clin Med. 2013;2(3):98-105. doi: 10.11648/j.sjcm.20130203.17

Copy | Download

@article{10.11648/j.sjcm.20130203.17,
  author = {Gabriel Uche Pascal Iloh and Abali Chuku and Agwu Nkwa Amadi and Nnadozie Paul Obiegbu},
  title = {Risk Factors For Hepatitis B Virus Infection Among Adult Nigerians With Clinical Features Of Liver Diseases In A Resource-Constrained Environment Of A Primary Care Clinic In Eastern Nigeria},
  journal = {Science Journal of Clinical Medicine},
  volume = {2},
  number = {3},
  pages = {98-105},
  doi = {10.11648/j.sjcm.20130203.17},
  url = {https://doi.org/10.11648/j.sjcm.20130203.17},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjcm.20130203.17},
  abstract = {Background: Hepatitis B virus (HBV) infection is an important contributor to the burden of liver diseases in adult Nigerians and constitutes a threat to socio-economic development in the sub-region. Screening for its risk factors in patients with clinical features of liver diseases is an important primary care challenge that is often neglected. Aim: To determine the risk factors for HBV infection in adult Nigerians with clinical features of liver diseases in a resource-constrained environment of a primary care clinic in Eastern Nigeria. Materials and Methods: A cross sectional study was carried out on 140 adult Nigerians with clinical features of liver diseases at the primary care clinic of a tertiary hospital in Nigeria. Clinical features of liver diseases were based on the presence of some constitutional, hepatic and extra-hepatic features. Hepatitis B surface antigen (HBsAg) was assayed using immunochromatographic method. A pre-tested, structured interviewer-administered questionnaire was used to obtain socio-demographic variables and histories of HBV-related risk factors. Results: The HBV sero-prevalence was 50.7%. The age group 40 – 60 years (P=0.048) and artisans (P=0.019) were significantly infected. The behavioural risk factors significantly associated with HBV infection were histories of unprotected sexual exposures (P=0.001), blood transfusion (P=0.022) and non-hepatitis B vaccination (P=0.030). The most significant predictor of HBV infection was history of unprotected sexual exposures (OR=5.04, P=0.003). Conclusion: Risk factors of HBV infection exist in adult Nigerian patients with clinical features of liver diseases and HBV infection was significantly associated with age, occupation, unprotected sexual exposures, blood transfusion and non-hepatitis B vaccination.},
 year = {2013}
}

Copy | Download

TY  - JOUR
T1  - Risk Factors For Hepatitis B Virus Infection Among Adult Nigerians With Clinical Features Of Liver Diseases In A Resource-Constrained Environment Of A Primary Care Clinic In Eastern Nigeria
AU  - Gabriel Uche Pascal Iloh
AU  - Abali Chuku
AU  - Agwu Nkwa Amadi
AU  - Nnadozie Paul Obiegbu
Y1  - 2013/06/20
PY  - 2013
N1  - https://doi.org/10.11648/j.sjcm.20130203.17
DO  - 10.11648/j.sjcm.20130203.17
T2  - Science Journal of Clinical Medicine
JF  - Science Journal of Clinical Medicine
JO  - Science Journal of Clinical Medicine
SP  - 98
EP  - 105
PB  - Science Publishing Group
SN  - 2327-2732
UR  - https://doi.org/10.11648/j.sjcm.20130203.17
AB  - Background: Hepatitis B virus (HBV) infection is an important contributor to the burden of liver diseases in adult Nigerians and constitutes a threat to socio-economic development in the sub-region. Screening for its risk factors in patients with clinical features of liver diseases is an important primary care challenge that is often neglected. Aim: To determine the risk factors for HBV infection in adult Nigerians with clinical features of liver diseases in a resource-constrained environment of a primary care clinic in Eastern Nigeria. Materials and Methods: A cross sectional study was carried out on 140 adult Nigerians with clinical features of liver diseases at the primary care clinic of a tertiary hospital in Nigeria. Clinical features of liver diseases were based on the presence of some constitutional, hepatic and extra-hepatic features. Hepatitis B surface antigen (HBsAg) was assayed using immunochromatographic method. A pre-tested, structured interviewer-administered questionnaire was used to obtain socio-demographic variables and histories of HBV-related risk factors. Results: The HBV sero-prevalence was 50.7%. The age group 40 – 60 years (P=0.048) and artisans (P=0.019) were significantly infected. The behavioural risk factors significantly associated with HBV infection were histories of unprotected sexual exposures (P=0.001), blood transfusion (P=0.022) and non-hepatitis B vaccination (P=0.030). The most significant predictor of HBV infection was history of unprotected sexual exposures (OR=5.04, P=0.003). Conclusion: Risk factors of HBV infection exist in adult Nigerian patients with clinical features of liver diseases and HBV infection was significantly associated with age, occupation, unprotected sexual exposures, blood transfusion and non-hepatitis B vaccination.
VL  - 2
IS  - 3
ER  -

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