The Immunogenetic Analysis of Acne Vulgaris

Anis Irawan Anwar; Indropo Agusni; Muh. Nasrum Massi; Irawan Yusuf

doi:doi:10.11648/j.sjcm.20130202.15

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The Immunogenetic Analysis of Acne Vulgaris

Anis Irawan Anwar, Indropo Agusni, Muh. Nasrum Massi, Irawan Yusuf

Published in Science Journal of Clinical Medicine (Volume 2, Issue 2)

Published: 2 April 2013

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Abstract

Polymorphisms that occur in the CYP1A1, CYP17 and TNF-α genes affects hyperkeratinzation process, se-bum production and inflammation in acne vulgaris. Polymorphisms of CYP1A1, CYP17 and TNF-α genes can be identified by using PCR and sequencing techniques. The aim of this study is to demonstrate the role of polymorphisms of CYP1A1, CYP17, and TNF-α genes and the interaction polimorphisms of CYP1A1, CYP17 and TNF-α genes to severe acne vulgaris. This study was conducted as an observational study with case-control method, in 64 patients with severe acne, and as controls 73 patients with mild acne and healthy people. Criteria based on Combined Acne Severity Classification. Biospesimen blood 1 ml taken from vena mediana cubiti then performed PCR and sequencing to determine the sequence of nucleotides in DNA fragments. The conclution from the study shows that polymorphisms of CYP1A1, CYP17, TNF-α genes and the interaction polimorphisms of CYP1A1, CYP 17 and TNF-α genes is not a risk factor for severe acne vulgaris, but polymorphism of CYP1A1 gene is a risk factor for acne vulgaris.

Published in	Science Journal of Clinical Medicine (Volume 2, Issue 2)
DOI	10.11648/j.sjcm.20130202.15
Page(s)	58-63
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2013. Published by Science Publishing Group

Keywords

Severe Acne Vulgaris, Polymorphisms of CYP1A1, CYP17, and TNF-α genes, Interactions polymorphisms of CYP1A1, CYP 17 and TNF-α genes

References

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APA Style

Anis Irawan Anwar, Indropo Agusni, Muh. Nasrum Massi, Irawan Yusuf. (2013). The Immunogenetic Analysis of Acne Vulgaris. Science Journal of Clinical Medicine, 2(2), 58-63. https://doi.org/10.11648/j.sjcm.20130202.15

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ACS Style

Anis Irawan Anwar; Indropo Agusni; Muh. Nasrum Massi; Irawan Yusuf. The Immunogenetic Analysis of Acne Vulgaris. Sci. J. Clin. Med. 2013, 2(2), 58-63. doi: 10.11648/j.sjcm.20130202.15

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AMA Style

Anis Irawan Anwar, Indropo Agusni, Muh. Nasrum Massi, Irawan Yusuf. The Immunogenetic Analysis of Acne Vulgaris. Sci J Clin Med. 2013;2(2):58-63. doi: 10.11648/j.sjcm.20130202.15

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@article{10.11648/j.sjcm.20130202.15,
  author = {Anis Irawan Anwar and Indropo Agusni and Muh. Nasrum Massi and Irawan Yusuf},
  title = {The Immunogenetic Analysis of Acne Vulgaris},
  journal = {Science Journal of Clinical Medicine},
  volume = {2},
  number = {2},
  pages = {58-63},
  doi = {10.11648/j.sjcm.20130202.15},
  url = {https://doi.org/10.11648/j.sjcm.20130202.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjcm.20130202.15},
  abstract = {Polymorphisms that occur in the CYP1A1, CYP17 and TNF-α genes affects hyperkeratinzation process, se-bum production and inflammation in acne vulgaris. Polymorphisms of CYP1A1, CYP17 and TNF-α genes can be identified by using PCR and sequencing techniques. The aim of this study is to demonstrate the role of polymorphisms of CYP1A1, CYP17, and TNF-α genes and the interaction polimorphisms of CYP1A1, CYP17 and TNF-α genes to severe acne vulgaris. This study was conducted as an observational study with case-control method, in 64 patients with severe acne, and as controls 73 patients with mild acne and healthy people. Criteria based on Combined Acne Severity Classification. Biospesimen blood 1 ml taken from vena mediana cubiti then performed PCR and sequencing to determine the sequence of nucleotides in DNA fragments. The conclution from the study shows that polymorphisms of CYP1A1, CYP17, TNF-α genes and the interaction polimorphisms of CYP1A1, CYP 17 and TNF-α genes is not a risk factor for severe acne vulgaris, but polymorphism of CYP1A1 gene is a risk factor for acne vulgaris.},
 year = {2013}
}

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TY  - JOUR
T1  - The Immunogenetic Analysis of Acne Vulgaris
AU  - Anis Irawan Anwar
AU  - Indropo Agusni
AU  - Muh. Nasrum Massi
AU  - Irawan Yusuf
Y1  - 2013/04/02
PY  - 2013
N1  - https://doi.org/10.11648/j.sjcm.20130202.15
DO  - 10.11648/j.sjcm.20130202.15
T2  - Science Journal of Clinical Medicine
JF  - Science Journal of Clinical Medicine
JO  - Science Journal of Clinical Medicine
SP  - 58
EP  - 63
PB  - Science Publishing Group
SN  - 2327-2732
UR  - https://doi.org/10.11648/j.sjcm.20130202.15
AB  - Polymorphisms that occur in the CYP1A1, CYP17 and TNF-α genes affects hyperkeratinzation process, se-bum production and inflammation in acne vulgaris. Polymorphisms of CYP1A1, CYP17 and TNF-α genes can be identified by using PCR and sequencing techniques. The aim of this study is to demonstrate the role of polymorphisms of CYP1A1, CYP17, and TNF-α genes and the interaction polimorphisms of CYP1A1, CYP17 and TNF-α genes to severe acne vulgaris. This study was conducted as an observational study with case-control method, in 64 patients with severe acne, and as controls 73 patients with mild acne and healthy people. Criteria based on Combined Acne Severity Classification. Biospesimen blood 1 ml taken from vena mediana cubiti then performed PCR and sequencing to determine the sequence of nucleotides in DNA fragments. The conclution from the study shows that polymorphisms of CYP1A1, CYP17, TNF-α genes and the interaction polimorphisms of CYP1A1, CYP 17 and TNF-α genes is not a risk factor for severe acne vulgaris, but polymorphism of CYP1A1 gene is a risk factor for acne vulgaris.
VL  - 2
IS  - 2
ER  -

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Author Information

Anis Irawan Anwar

Dermatology and Venereology Department, Faculty of medicine Hasanuddin University, Makassar, Indonesia
Indropo Agusni

Dermatology and Venereology Department, Faculty of medicine Airlangga University, Surabaya, Indonesia
Muh. Nasrum Massi

Microbiology Department Faculty of medicine Hasanuddin University, Makassar, Indonesia
Irawan Yusuf

Department, Faculty of medicine Hasanuddin University, Makassar, Indonesia

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Plain Text BibTeX RIS

APA Style

Anis Irawan Anwar, Indropo Agusni, Muh. Nasrum Massi, Irawan Yusuf. (2013). The Immunogenetic Analysis of Acne Vulgaris. Science Journal of Clinical Medicine, 2(2), 58-63. https://doi.org/10.11648/j.sjcm.20130202.15

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ACS Style

Anis Irawan Anwar; Indropo Agusni; Muh. Nasrum Massi; Irawan Yusuf. The Immunogenetic Analysis of Acne Vulgaris. Sci. J. Clin. Med. 2013, 2(2), 58-63. doi: 10.11648/j.sjcm.20130202.15

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AMA Style

Anis Irawan Anwar, Indropo Agusni, Muh. Nasrum Massi, Irawan Yusuf. The Immunogenetic Analysis of Acne Vulgaris. Sci J Clin Med. 2013;2(2):58-63. doi: 10.11648/j.sjcm.20130202.15

Copy | Download

@article{10.11648/j.sjcm.20130202.15,
  author = {Anis Irawan Anwar and Indropo Agusni and Muh. Nasrum Massi and Irawan Yusuf},
  title = {The Immunogenetic Analysis of Acne Vulgaris},
  journal = {Science Journal of Clinical Medicine},
  volume = {2},
  number = {2},
  pages = {58-63},
  doi = {10.11648/j.sjcm.20130202.15},
  url = {https://doi.org/10.11648/j.sjcm.20130202.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjcm.20130202.15},
  abstract = {Polymorphisms that occur in the CYP1A1, CYP17 and TNF-α genes affects hyperkeratinzation process, se-bum production and inflammation in acne vulgaris. Polymorphisms of CYP1A1, CYP17 and TNF-α genes can be identified by using PCR and sequencing techniques. The aim of this study is to demonstrate the role of polymorphisms of CYP1A1, CYP17, and TNF-α genes and the interaction polimorphisms of CYP1A1, CYP17 and TNF-α genes to severe acne vulgaris. This study was conducted as an observational study with case-control method, in 64 patients with severe acne, and as controls 73 patients with mild acne and healthy people. Criteria based on Combined Acne Severity Classification. Biospesimen blood 1 ml taken from vena mediana cubiti then performed PCR and sequencing to determine the sequence of nucleotides in DNA fragments. The conclution from the study shows that polymorphisms of CYP1A1, CYP17, TNF-α genes and the interaction polimorphisms of CYP1A1, CYP 17 and TNF-α genes is not a risk factor for severe acne vulgaris, but polymorphism of CYP1A1 gene is a risk factor for acne vulgaris.},
 year = {2013}
}

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TY  - JOUR
T1  - The Immunogenetic Analysis of Acne Vulgaris
AU  - Anis Irawan Anwar
AU  - Indropo Agusni
AU  - Muh. Nasrum Massi
AU  - Irawan Yusuf
Y1  - 2013/04/02
PY  - 2013
N1  - https://doi.org/10.11648/j.sjcm.20130202.15
DO  - 10.11648/j.sjcm.20130202.15
T2  - Science Journal of Clinical Medicine
JF  - Science Journal of Clinical Medicine
JO  - Science Journal of Clinical Medicine
SP  - 58
EP  - 63
PB  - Science Publishing Group
SN  - 2327-2732
UR  - https://doi.org/10.11648/j.sjcm.20130202.15
AB  - Polymorphisms that occur in the CYP1A1, CYP17 and TNF-α genes affects hyperkeratinzation process, se-bum production and inflammation in acne vulgaris. Polymorphisms of CYP1A1, CYP17 and TNF-α genes can be identified by using PCR and sequencing techniques. The aim of this study is to demonstrate the role of polymorphisms of CYP1A1, CYP17, and TNF-α genes and the interaction polimorphisms of CYP1A1, CYP17 and TNF-α genes to severe acne vulgaris. This study was conducted as an observational study with case-control method, in 64 patients with severe acne, and as controls 73 patients with mild acne and healthy people. Criteria based on Combined Acne Severity Classification. Biospesimen blood 1 ml taken from vena mediana cubiti then performed PCR and sequencing to determine the sequence of nucleotides in DNA fragments. The conclution from the study shows that polymorphisms of CYP1A1, CYP17, TNF-α genes and the interaction polimorphisms of CYP1A1, CYP 17 and TNF-α genes is not a risk factor for severe acne vulgaris, but polymorphism of CYP1A1 gene is a risk factor for acne vulgaris.
VL  - 2
IS  - 2
ER  -

Copy | Download