The Contrast and Evaluation of the Biological Effects on Glucose and Lipid Metabolism by the Extract from Wolfberry Fruit and Leaf

Lu Ping

doi:doi:10.11648/j.sd.20160405.12

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The Contrast and Evaluation of the Biological Effects on Glucose and Lipid Metabolism by the Extract from Wolfberry Fruit and Leaf

Lu Ping

Published in Science Discovery (Volume 4, Issue 5)

Received: 25 August 2016 Published: 25 August 2016

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Abstract

This study is aimed to clarify the mechanism of wolfberry fruit and leaf extract’s regulation of lipid metabolism, and to provide the necessary theoretical basis for the possible uses of wolfberry fruit extract as drugs improving lipid metabolism. We have investigated the effects of wolfberry extract on the proliferation and differentiation as well as lipid metabolism of preadipocytes on cell level, and have evaluated the influences of wolfberry extract on obese mice body weight, oral glucose tolerance and blood glucose. The comparison between the effects of different parts of wolfberry and the combination of experiments of cell and animal level are done for the first time. Results show that: neither wolfberry fruit nor wolfberry leaf has toxicity on 3T3-L1 preadipocytes; wolfberry extract can promote adipocyte differentiation and intracellular lipid accumulation, while wolfberry leaf does not have such effects; fruit extract can improve the C/EBPα, PPAR-γ gene expression levels and activate the transcriptional activity of PPAR-γ, while leaf does not have such effects; both wolfberry fruit and wolfberry leaf can reduce the blood glucose and improve the oral glucose tolerance of obese mice, and wolfberry fruit has a stronger effect, but in the meanwhile they also increase the mice’s body weight. Based on the results above, we can conclude that wolfberry fruit extract ingredients can regulate glucose and lipid metabolism to some extent. Thus, it has the potential to work as a kind of medicine to improve lipid metabolism and to cure type 2 diabetes.

Published in	Science Discovery (Volume 4, Issue 5)
DOI	10.11648/j.sd.20160405.12
Page(s)	275-279
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

Wolfberry Extract, 3T3-L1 Preadipocytes, Adipocyte Differentiation, Glucose and Lipid Metabolism, PPAR-γ

References

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APA Style

Lu Ping. (2016). The Contrast and Evaluation of the Biological Effects on Glucose and Lipid Metabolism by the Extract from Wolfberry Fruit and Leaf. Science Discovery, 4(5), 275-279. https://doi.org/10.11648/j.sd.20160405.12

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ACS Style

Lu Ping. The Contrast and Evaluation of the Biological Effects on Glucose and Lipid Metabolism by the Extract from Wolfberry Fruit and Leaf. Sci. Discov. 2016, 4(5), 275-279. doi: 10.11648/j.sd.20160405.12

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AMA Style

Lu Ping. The Contrast and Evaluation of the Biological Effects on Glucose and Lipid Metabolism by the Extract from Wolfberry Fruit and Leaf. Sci Discov. 2016;4(5):275-279. doi: 10.11648/j.sd.20160405.12

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@article{10.11648/j.sd.20160405.12,
  author = {Lu Ping},
  title = {The Contrast and Evaluation of the Biological Effects on Glucose and Lipid Metabolism by the Extract from Wolfberry Fruit and Leaf},
  journal = {Science Discovery},
  volume = {4},
  number = {5},
  pages = {275-279},
  doi = {10.11648/j.sd.20160405.12},
  url = {https://doi.org/10.11648/j.sd.20160405.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sd.20160405.12},
  abstract = {This study is aimed to clarify the mechanism of wolfberry fruit and leaf extract’s regulation of lipid metabolism, and to provide the necessary theoretical basis for the possible uses of wolfberry fruit extract as drugs improving lipid metabolism. We have investigated the effects of wolfberry extract on the proliferation and differentiation as well as lipid metabolism of preadipocytes on cell level, and have evaluated the influences of wolfberry extract on obese mice body weight, oral glucose tolerance and blood glucose. The comparison between the effects of different parts of wolfberry and the combination of experiments of cell and animal level are done for the first time. Results show that: neither wolfberry fruit nor wolfberry leaf has toxicity on 3T3-L1 preadipocytes; wolfberry extract can promote adipocyte differentiation and intracellular lipid accumulation, while wolfberry leaf does not have such effects; fruit extract can improve the C/EBPα, PPAR-γ gene expression levels and activate the transcriptional activity of PPAR-γ, while leaf does not have such effects; both wolfberry fruit and wolfberry leaf can reduce the blood glucose and improve the oral glucose tolerance of obese mice, and wolfberry fruit has a stronger effect, but in the meanwhile they also increase the mice’s body weight. Based on the results above, we can conclude that wolfberry fruit extract ingredients can regulate glucose and lipid metabolism to some extent. Thus, it has the potential to work as a kind of medicine to improve lipid metabolism and to cure type 2 diabetes.},
 year = {2016}
}

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TY  - JOUR
T1  - The Contrast and Evaluation of the Biological Effects on Glucose and Lipid Metabolism by the Extract from Wolfberry Fruit and Leaf
AU  - Lu Ping
Y1  - 2016/08/25
PY  - 2016
N1  - https://doi.org/10.11648/j.sd.20160405.12
DO  - 10.11648/j.sd.20160405.12
T2  - Science Discovery
JF  - Science Discovery
JO  - Science Discovery
SP  - 275
EP  - 279
PB  - Science Publishing Group
SN  - 2331-0650
UR  - https://doi.org/10.11648/j.sd.20160405.12
AB  - This study is aimed to clarify the mechanism of wolfberry fruit and leaf extract’s regulation of lipid metabolism, and to provide the necessary theoretical basis for the possible uses of wolfberry fruit extract as drugs improving lipid metabolism. We have investigated the effects of wolfberry extract on the proliferation and differentiation as well as lipid metabolism of preadipocytes on cell level, and have evaluated the influences of wolfberry extract on obese mice body weight, oral glucose tolerance and blood glucose. The comparison between the effects of different parts of wolfberry and the combination of experiments of cell and animal level are done for the first time. Results show that: neither wolfberry fruit nor wolfberry leaf has toxicity on 3T3-L1 preadipocytes; wolfberry extract can promote adipocyte differentiation and intracellular lipid accumulation, while wolfberry leaf does not have such effects; fruit extract can improve the C/EBPα, PPAR-γ gene expression levels and activate the transcriptional activity of PPAR-γ, while leaf does not have such effects; both wolfberry fruit and wolfberry leaf can reduce the blood glucose and improve the oral glucose tolerance of obese mice, and wolfberry fruit has a stronger effect, but in the meanwhile they also increase the mice’s body weight. Based on the results above, we can conclude that wolfberry fruit extract ingredients can regulate glucose and lipid metabolism to some extent. Thus, it has the potential to work as a kind of medicine to improve lipid metabolism and to cure type 2 diabetes.
VL  - 4
IS  - 5
ER  -

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Author Information

Lu Ping

School of Life Science, Tsinghua University, Beijing, China

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Plain Text BibTeX RIS

APA Style

Lu Ping. (2016). The Contrast and Evaluation of the Biological Effects on Glucose and Lipid Metabolism by the Extract from Wolfberry Fruit and Leaf. Science Discovery, 4(5), 275-279. https://doi.org/10.11648/j.sd.20160405.12

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ACS Style

Lu Ping. The Contrast and Evaluation of the Biological Effects on Glucose and Lipid Metabolism by the Extract from Wolfberry Fruit and Leaf. Sci. Discov. 2016, 4(5), 275-279. doi: 10.11648/j.sd.20160405.12

Copy | Download

AMA Style

Lu Ping. The Contrast and Evaluation of the Biological Effects on Glucose and Lipid Metabolism by the Extract from Wolfberry Fruit and Leaf. Sci Discov. 2016;4(5):275-279. doi: 10.11648/j.sd.20160405.12

Copy | Download

@article{10.11648/j.sd.20160405.12,
  author = {Lu Ping},
  title = {The Contrast and Evaluation of the Biological Effects on Glucose and Lipid Metabolism by the Extract from Wolfberry Fruit and Leaf},
  journal = {Science Discovery},
  volume = {4},
  number = {5},
  pages = {275-279},
  doi = {10.11648/j.sd.20160405.12},
  url = {https://doi.org/10.11648/j.sd.20160405.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sd.20160405.12},
  abstract = {This study is aimed to clarify the mechanism of wolfberry fruit and leaf extract’s regulation of lipid metabolism, and to provide the necessary theoretical basis for the possible uses of wolfberry fruit extract as drugs improving lipid metabolism. We have investigated the effects of wolfberry extract on the proliferation and differentiation as well as lipid metabolism of preadipocytes on cell level, and have evaluated the influences of wolfberry extract on obese mice body weight, oral glucose tolerance and blood glucose. The comparison between the effects of different parts of wolfberry and the combination of experiments of cell and animal level are done for the first time. Results show that: neither wolfberry fruit nor wolfberry leaf has toxicity on 3T3-L1 preadipocytes; wolfberry extract can promote adipocyte differentiation and intracellular lipid accumulation, while wolfberry leaf does not have such effects; fruit extract can improve the C/EBPα, PPAR-γ gene expression levels and activate the transcriptional activity of PPAR-γ, while leaf does not have such effects; both wolfberry fruit and wolfberry leaf can reduce the blood glucose and improve the oral glucose tolerance of obese mice, and wolfberry fruit has a stronger effect, but in the meanwhile they also increase the mice’s body weight. Based on the results above, we can conclude that wolfberry fruit extract ingredients can regulate glucose and lipid metabolism to some extent. Thus, it has the potential to work as a kind of medicine to improve lipid metabolism and to cure type 2 diabetes.},
 year = {2016}
}

Copy | Download

TY  - JOUR
T1  - The Contrast and Evaluation of the Biological Effects on Glucose and Lipid Metabolism by the Extract from Wolfberry Fruit and Leaf
AU  - Lu Ping
Y1  - 2016/08/25
PY  - 2016
N1  - https://doi.org/10.11648/j.sd.20160405.12
DO  - 10.11648/j.sd.20160405.12
T2  - Science Discovery
JF  - Science Discovery
JO  - Science Discovery
SP  - 275
EP  - 279
PB  - Science Publishing Group
SN  - 2331-0650
UR  - https://doi.org/10.11648/j.sd.20160405.12
AB  - This study is aimed to clarify the mechanism of wolfberry fruit and leaf extract’s regulation of lipid metabolism, and to provide the necessary theoretical basis for the possible uses of wolfberry fruit extract as drugs improving lipid metabolism. We have investigated the effects of wolfberry extract on the proliferation and differentiation as well as lipid metabolism of preadipocytes on cell level, and have evaluated the influences of wolfberry extract on obese mice body weight, oral glucose tolerance and blood glucose. The comparison between the effects of different parts of wolfberry and the combination of experiments of cell and animal level are done for the first time. Results show that: neither wolfberry fruit nor wolfberry leaf has toxicity on 3T3-L1 preadipocytes; wolfberry extract can promote adipocyte differentiation and intracellular lipid accumulation, while wolfberry leaf does not have such effects; fruit extract can improve the C/EBPα, PPAR-γ gene expression levels and activate the transcriptional activity of PPAR-γ, while leaf does not have such effects; both wolfberry fruit and wolfberry leaf can reduce the blood glucose and improve the oral glucose tolerance of obese mice, and wolfberry fruit has a stronger effect, but in the meanwhile they also increase the mice’s body weight. Based on the results above, we can conclude that wolfberry fruit extract ingredients can regulate glucose and lipid metabolism to some extent. Thus, it has the potential to work as a kind of medicine to improve lipid metabolism and to cure type 2 diabetes.
VL  - 4
IS  - 5
ER  -

Copy | Download