Quantitative Assessment of Prognosticators for Rectal Cancer’s Local Recurrence and Distant Metastases

Haytham Abudeeb; Ajogwu Ugwu; Lucy Campbell; Arijit Mukherjee

doi:doi:10.11648/j.js.20180606.15

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Quantitative Assessment of Prognosticators for Rectal Cancer’s Local Recurrence and Distant Metastases

Haytham Abudeeb, Ajogwu Ugwu, Lucy Campbell, Arijit Mukherjee

Published in Journal of Surgery (Volume 6, Issue 6)

Received: 30 October 2018 Accepted: 12 November 2018 Published: 19 December 2018

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Abstract

Rectal cancer treatment outcome has improved considerably in the TME era often with the use neoadjuvant chemoradiotherapy. However, the risk of local recurrence/distant metastases could be as high as 10%. We have designed a retrospective cohort study to assess risk factors associated with local recurrence/distant metastasis after primary curative rectal resection. Our analysis of the colorectal database in a district general hospital involved review of 131 patients who had a curative resection between 2007 and 2013. 22 patients of the 131 had local recurrence/distant metastases. We reviewed the risk factors as gender, neoadjuvant chemoradiotherapy, type of operation, anastomotic leak, tumour differentiation, EMVI, CRM and Dukes C and performed a quantitative assessment. Looking at risk factors, the presence of EMVI was found to have a statistically significant association with recurrence and distant metastases (p=0.0006) followed by poor differentiation (p= 0.038) and Dukes C (p=0.045) while CRM involvement (p=0.054), Neoadjuvant chemoradiotherapy (p=0.657), type of resection (p=0.740), Anastomotic leak (p=0.761) and gender (p=0.901) shown no obvious statistical association with recurrence or distant metastases A larger multi-centre study may help in validating our observation.

Published in	Journal of Surgery (Volume 6, Issue 6)
DOI	10.11648/j.js.20180606.15
Page(s)	167-172
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2018. Published by Science Publishing Group

Keywords

Distant Metastases, Local Recurrence, Rectal Cancer, Risk Factors

References

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APA Style

Haytham Abudeeb, Ajogwu Ugwu, Lucy Campbell, Arijit Mukherjee. (2018). Quantitative Assessment of Prognosticators for Rectal Cancer’s Local Recurrence and Distant Metastases. Journal of Surgery, 6(6), 167-172. https://doi.org/10.11648/j.js.20180606.15

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ACS Style

Haytham Abudeeb; Ajogwu Ugwu; Lucy Campbell; Arijit Mukherjee. Quantitative Assessment of Prognosticators for Rectal Cancer’s Local Recurrence and Distant Metastases. J. Surg. 2018, 6(6), 167-172. doi: 10.11648/j.js.20180606.15

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AMA Style

Haytham Abudeeb, Ajogwu Ugwu, Lucy Campbell, Arijit Mukherjee. Quantitative Assessment of Prognosticators for Rectal Cancer’s Local Recurrence and Distant Metastases. J Surg. 2018;6(6):167-172. doi: 10.11648/j.js.20180606.15

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@article{10.11648/j.js.20180606.15,
  author = {Haytham Abudeeb and Ajogwu Ugwu and Lucy Campbell and Arijit Mukherjee},
  title = {Quantitative Assessment of Prognosticators for Rectal Cancer’s Local Recurrence and Distant Metastases},
  journal = {Journal of Surgery},
  volume = {6},
  number = {6},
  pages = {167-172},
  doi = {10.11648/j.js.20180606.15},
  url = {https://doi.org/10.11648/j.js.20180606.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.js.20180606.15},
  abstract = {Rectal cancer treatment outcome has improved considerably in the TME era often with the use neoadjuvant chemoradiotherapy. However, the risk of local recurrence/distant metastases could be as high as 10%. We have designed a retrospective cohort study to assess risk factors associated with local recurrence/distant metastasis after primary curative rectal resection. Our analysis of the colorectal database in a district general hospital involved review of 131 patients who had a curative resection between 2007 and 2013. 22 patients of the 131 had local recurrence/distant metastases. We reviewed the risk factors as gender, neoadjuvant chemoradiotherapy, type of operation, anastomotic leak, tumour differentiation, EMVI, CRM and Dukes C and performed a quantitative assessment. Looking at risk factors, the presence of EMVI was found to have a statistically significant association with recurrence and distant metastases (p=0.0006) followed by poor differentiation (p= 0.038) and Dukes C (p=0.045) while CRM involvement (p=0.054), Neoadjuvant chemoradiotherapy (p=0.657), type of resection (p=0.740), Anastomotic leak (p=0.761) and gender (p=0.901) shown no obvious statistical association with recurrence or distant metastases A larger multi-centre study may help in validating our observation.},
 year = {2018}
}

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TY  - JOUR
T1  - Quantitative Assessment of Prognosticators for Rectal Cancer’s Local Recurrence and Distant Metastases
AU  - Haytham Abudeeb
AU  - Ajogwu Ugwu
AU  - Lucy Campbell
AU  - Arijit Mukherjee
Y1  - 2018/12/19
PY  - 2018
N1  - https://doi.org/10.11648/j.js.20180606.15
DO  - 10.11648/j.js.20180606.15
T2  - Journal of Surgery
JF  - Journal of Surgery
JO  - Journal of Surgery
SP  - 167
EP  - 172
PB  - Science Publishing Group
SN  - 2330-0930
UR  - https://doi.org/10.11648/j.js.20180606.15
AB  - Rectal cancer treatment outcome has improved considerably in the TME era often with the use neoadjuvant chemoradiotherapy. However, the risk of local recurrence/distant metastases could be as high as 10%. We have designed a retrospective cohort study to assess risk factors associated with local recurrence/distant metastasis after primary curative rectal resection. Our analysis of the colorectal database in a district general hospital involved review of 131 patients who had a curative resection between 2007 and 2013. 22 patients of the 131 had local recurrence/distant metastases. We reviewed the risk factors as gender, neoadjuvant chemoradiotherapy, type of operation, anastomotic leak, tumour differentiation, EMVI, CRM and Dukes C and performed a quantitative assessment. Looking at risk factors, the presence of EMVI was found to have a statistically significant association with recurrence and distant metastases (p=0.0006) followed by poor differentiation (p= 0.038) and Dukes C (p=0.045) while CRM involvement (p=0.054), Neoadjuvant chemoradiotherapy (p=0.657), type of resection (p=0.740), Anastomotic leak (p=0.761) and gender (p=0.901) shown no obvious statistical association with recurrence or distant metastases A larger multi-centre study may help in validating our observation.
VL  - 6
IS  - 6
ER  -

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Author Information

Haytham Abudeeb

Department of Surgery, Hairmyres Hospital, East Kilbride, UK
Ajogwu Ugwu

Department of Surgery, Monklands Hospital, Monkland, UK
Lucy Campbell

Department of Surgery, Hairmyres Hospital, East Kilbride, UK
Arijit Mukherjee

Department of Surgery, Hairmyres Hospital, East Kilbride, UK

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Plain Text BibTeX RIS

APA Style

Haytham Abudeeb, Ajogwu Ugwu, Lucy Campbell, Arijit Mukherjee. (2018). Quantitative Assessment of Prognosticators for Rectal Cancer’s Local Recurrence and Distant Metastases. Journal of Surgery, 6(6), 167-172. https://doi.org/10.11648/j.js.20180606.15

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ACS Style

Haytham Abudeeb; Ajogwu Ugwu; Lucy Campbell; Arijit Mukherjee. Quantitative Assessment of Prognosticators for Rectal Cancer’s Local Recurrence and Distant Metastases. J. Surg. 2018, 6(6), 167-172. doi: 10.11648/j.js.20180606.15

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AMA Style

Haytham Abudeeb, Ajogwu Ugwu, Lucy Campbell, Arijit Mukherjee. Quantitative Assessment of Prognosticators for Rectal Cancer’s Local Recurrence and Distant Metastases. J Surg. 2018;6(6):167-172. doi: 10.11648/j.js.20180606.15

Copy | Download

@article{10.11648/j.js.20180606.15,
  author = {Haytham Abudeeb and Ajogwu Ugwu and Lucy Campbell and Arijit Mukherjee},
  title = {Quantitative Assessment of Prognosticators for Rectal Cancer’s Local Recurrence and Distant Metastases},
  journal = {Journal of Surgery},
  volume = {6},
  number = {6},
  pages = {167-172},
  doi = {10.11648/j.js.20180606.15},
  url = {https://doi.org/10.11648/j.js.20180606.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.js.20180606.15},
  abstract = {Rectal cancer treatment outcome has improved considerably in the TME era often with the use neoadjuvant chemoradiotherapy. However, the risk of local recurrence/distant metastases could be as high as 10%. We have designed a retrospective cohort study to assess risk factors associated with local recurrence/distant metastasis after primary curative rectal resection. Our analysis of the colorectal database in a district general hospital involved review of 131 patients who had a curative resection between 2007 and 2013. 22 patients of the 131 had local recurrence/distant metastases. We reviewed the risk factors as gender, neoadjuvant chemoradiotherapy, type of operation, anastomotic leak, tumour differentiation, EMVI, CRM and Dukes C and performed a quantitative assessment. Looking at risk factors, the presence of EMVI was found to have a statistically significant association with recurrence and distant metastases (p=0.0006) followed by poor differentiation (p= 0.038) and Dukes C (p=0.045) while CRM involvement (p=0.054), Neoadjuvant chemoradiotherapy (p=0.657), type of resection (p=0.740), Anastomotic leak (p=0.761) and gender (p=0.901) shown no obvious statistical association with recurrence or distant metastases A larger multi-centre study may help in validating our observation.},
 year = {2018}
}

Copy | Download

TY  - JOUR
T1  - Quantitative Assessment of Prognosticators for Rectal Cancer’s Local Recurrence and Distant Metastases
AU  - Haytham Abudeeb
AU  - Ajogwu Ugwu
AU  - Lucy Campbell
AU  - Arijit Mukherjee
Y1  - 2018/12/19
PY  - 2018
N1  - https://doi.org/10.11648/j.js.20180606.15
DO  - 10.11648/j.js.20180606.15
T2  - Journal of Surgery
JF  - Journal of Surgery
JO  - Journal of Surgery
SP  - 167
EP  - 172
PB  - Science Publishing Group
SN  - 2330-0930
UR  - https://doi.org/10.11648/j.js.20180606.15
AB  - Rectal cancer treatment outcome has improved considerably in the TME era often with the use neoadjuvant chemoradiotherapy. However, the risk of local recurrence/distant metastases could be as high as 10%. We have designed a retrospective cohort study to assess risk factors associated with local recurrence/distant metastasis after primary curative rectal resection. Our analysis of the colorectal database in a district general hospital involved review of 131 patients who had a curative resection between 2007 and 2013. 22 patients of the 131 had local recurrence/distant metastases. We reviewed the risk factors as gender, neoadjuvant chemoradiotherapy, type of operation, anastomotic leak, tumour differentiation, EMVI, CRM and Dukes C and performed a quantitative assessment. Looking at risk factors, the presence of EMVI was found to have a statistically significant association with recurrence and distant metastases (p=0.0006) followed by poor differentiation (p= 0.038) and Dukes C (p=0.045) while CRM involvement (p=0.054), Neoadjuvant chemoradiotherapy (p=0.657), type of resection (p=0.740), Anastomotic leak (p=0.761) and gender (p=0.901) shown no obvious statistical association with recurrence or distant metastases A larger multi-centre study may help in validating our observation.
VL  - 6
IS  - 6
ER  -

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