Diabetes mellitus (DM), a group of chronic metabolic disorders characterized by hyperglycemia resulting from defects in insulin action and/or insulin secretion. It represents one of the main contributors to ill health and premature mortality worldwide and its prevalence has been rising during the last decades. Unfortunately, many antidiabetic agents for diabetes either have inadequate efficacy or significant mechanism-based side effects. A great deal of interest has been developed to the various natural bioactive compounds isolated and characterized from medicinal plants. This review focuses specifically on four nature phytochemicals such as polysaccharides, flavonoids, saponins and alkaloids whose properties are potencial to antidiabetic remedy.
Published in | Journal of Food and Nutrition Sciences (Volume 5, Issue 2) |
DOI | 10.11648/j.jfns.20170502.11 |
Page(s) | 23-27 |
Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
Copyright |
Copyright © The Author(s), 2017. Published by Science Publishing Group |
Diabetes Mellitus, Hypoglycemic, Phytochemicals
[1] | Mazzone T, Chait A, Plutzky J. Cardiovascular disease risk in type 2 diabetes mellitus: insights from mechanistic studies. [J]. Lancet, 2008, 371 (9626): 1800-1809. |
[2] | Kitabchi A E, Umpierrez G E, Miles J M, et al. Hyperglycemic crises in adult patients with diabetes [J]. Diabetes Care, 2009, 32 (12): e157. |
[3] | Jha P K, Sanyal S P. Hypoglycemic, antiperoxidative and antihyperlipidemic effects of saponins from Solanum anguivi Lam. fruits in alloxan-induced diabetic rats [J]. South African Journal of Botany, 2013, 88 (9): 56-61. |
[4] | Guariguata L, Whiting D R, Hambleton I, et al. Global estimates of diabetes prevalence for 2013 and projections for 2035 [J]. Diabetes Research and Clinical Practice, 2014, 103 (2): 137-149. |
[5] | Tahrani A A, Bailey C J, Del P S, et al. Management of type 2 diabetes: new and future developments in treatment [J]. American Journal of Medicine, 2012, 378 (9786): 182-97. |
[6] | Pigarova E A. Comments on: Oral Pharmacologic Treatment of Type 2 Diabetes Mellitus: A Clinical Practice Guideline From the American College of Physicians [J]. Obesity and Metabolism, 2012 (2): 66. |
[7] | Dey L, Attele A S, Yuan C S. Alternative therapies for type 2 diabetes. [J]. Alternative Medicine Review A Journal of Clinical Therapeutic, 2002, 7 (1): 45-58. |
[8] | Tsubouchi H, Inoguchi T, Inuo M, et al. Sulfonylurea as well as elevated glucose levels stimulate reactive oxygen species production in the pancreatic beta-cell line, MIN6-a role of NAD(P)H oxidase in beta-cells [J]. Biochemical and Biophysical Research Communications, 2004, 326 (1): 60-65. |
[9] | Meyler's Side Effects of Drugs (Sixteenth Edition), 2016, Pp 969-983. |
[10] | Yasmin S, Jayaprakash V. Thiazolidinediones and PPAR orchestra as antidiabetic agents: From past to present [J]. European Journal of Medicinal Chemistry, 2016, 126: 879. |
[11] | Zhao C, Wu Y J, Yang C F, Liu B, Huang Y F. Hypotensive, hypoglycemic and hypolipidemic effects of bioactive compounds from microalgae and marine microorganisms [J]. International Journal of Food Science and Technology. 2015, 50 (8): 1705-1717. |
[12] | Zhao C, Liao Z, Wu X, Liu Y, Liu X, Lin Z, Huang Y, Liu B. Isolation, purification, and structural features of a polysaccharide from Phellinus linteus and its hypoglycemic effect in alloxan-induced diabetic mice [J]. Journal of Food Science. 2014, 79 (5): H1002-1010. |
[13] | Tian C Y, Hai-Mei B O, Ji-An L I. Influence of mori fructus polysaccharide on blood glucose and serum lipoprotein in rats with experimental type 2 diabetes [J]. Chinese Journal of Experimental Traditional Medical Formulae, 2011. |
[14] | Wu J, Shi S, Wang H, et al. Mechanisms underlying the effect of polysaccharides in the treatment of type 2 diabetes: A review. [J]. Carbohydrate Polymers, 2016, 144: 474. |
[15] | Dahech I, Belghith K S, Hamden K, et al. Antidiabetic activity of levan polysaccharide in alloxan-induced diabetic rats. [J]. International Journal of Biological Macromolecules, 2011, 49 (4): 742-6. |
[16] | Bisht S, Kant R, Kumar V. α-D-Glucosidase inhibitory activity of polysaccharide isolated from Acacia tortilis gum exudate. [J]. International Journal of Biological Macromolecules, 2013, 59: 214-220. |
[17] | Seleem D, Pardi V, Murata R M. Review of flavonoids: A diverse group of natural compounds with anti-Candida albicans activity in vitro [J]. Archives of Oral Biology, 2016. |
[18] | Guan L, Liu B. ChemInform Abstract: Antidepressant-like effects and mechanisms of flavonoids and related analogues [J]. European Journal of Medicinal Chemistry, 2016, 121 (41): 47-57. |
[19] | Mohan S, Nandhakumar L. Role of various flavonoids: Hypotheses on novel approach to treat diabetes [J]. Iranian Journal of Medical Hypotheses and Ideas, 2014, 8(1): 1-6. |
[20] | Hussain S A, Marouf B H. Flavonoids as alternatives in treatment of type 2 diabetes mellitus [J]. 2013, 1: 31-36. |
[21] | Cazarolli L H, Folador P, Moresco H H, et al. Stimulatory effect of apigenin-6-C-beta-L-fucopyranoside on insulin secretion and glycogen synthesis. [J]. European Journal of Medicinal Chemistry, 2009, 44 (11): 4668-4673. |
[22] | Augustin J M, Kuzina V, Andersen S B, et al. ChemInform abstract: molecular activities, biosynthesis and evolution of triterpenoid saponins [J]. Cheminform, 2011, 72 (6): 435. |
[23] | Hua L, Wen H, Wen Y Q, et al. Anti-thrombotic activity and chemical characterization of steroidal saponins from Dioscorea zingiberensis C. H. Wright. [J]. Fitoterapia, 2010, 81(8): 1147. |
[24] | Sparg S G, Light M E, Van S J. Biological activities and distribution of plant saponins [J]. Journal of Ethnopharmacology, 2004, 94 (2-3): 219-243. |
[25] | Seo W D, Ji H L, Jia Y, et al. Saponarin activates AMPK in a calcium-dependent manner and suppresses gluconeogenesis and increases glucose uptake via phosphorylation of CRTC2 and HDAC5 [J]. Bioorganic and Medicinal Chemistry Letters, 2015, 25 (22): 5237. |
[26] | Lu J M, Wang Y F, Yan H L, et al. Antidiabetic effect of total saponins from Polygonatum kingianum in streptozotocin-induced daibetic rats. [J]. Journal of Ethnopharmacology, 2015, 179: 291-300. |
[27] | Iwasa K, Moriyasu M, Tachibana Y, et al. Simple isoquinoline and benzylisoquinoline alkaloids as potential antimicrobial, antimalarial, cytotoxic, and anti-HIV agents. [J]. Bioorg Med Chem, 2001, 9 (11): 2871-2884. |
[28] | Tang D, Chen Q B, Xin X L, et al. Anti-diabetic effect of three new norditerpenoid alkaloids in vitro and potential mechanism via PI3K/Akt signaling pathway [J]. Biomedicine and Pharmacotherapy, 2017, 87: 145-152. |
[29] | Tiong S H, Looi C Y, Arya A, et al. Vindogentianine, a hypoglycemic alkaloid from Catharanthus roseus (L.) G. Don (Apocynaceae) [J]. Fitoterapia, 2015, 102: 182-188. |
[30] | Hardie D G. AMPK: a key regulator of energy balance in the single cell and the whole organism. [J]. International Journal of Obesity, 2008, 32 Suppl 4: S7. |
[31] | Kelley D E, Goodpaster B, Wing R R, et al. Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss [J]. American Journal of Physiology, 1999, 277 (277): E1130-41. |
[32] | Hashem R M, Rashed L A, Hassanin K M, et al. Effect of 6-gingerol on AMPK- NF-B axis in high fat diet fed rats [J]. Biomedicine and Pharmacotherapy, 2017, 88: 293. |
[33] | Zhang B B, Zhou G, Li C. AMPK: an emerging drug target for diabetes and the metabolic syndrome.[J]. Cell Metabolism, 2009, 9 (5): 407-416. |
[34] | Zhang J, Zhi X, Shi S, et al. SPOCK1 is up-regulated and promotes tumor growth via the PI3K/AKT signaling pathway in colorectal cancer. [J]. 2016. |
[35] | Tonks N K. PTP1B: from the sidelines to the front lines [J]. Febs Letters, 2003, 546 (1): 140-148. |
APA Style
Ming-jun Chen, Xin Yan, Yu-qing Chen, Chao Zhao. (2017). Phytochemicals for Non-insulin Diabetes Mellitus: A Minireview on Plant-Derived Compounds Hypoglycemic Activity. Journal of Food and Nutrition Sciences, 5(2), 23-27. https://doi.org/10.11648/j.jfns.20170502.11
ACS Style
Ming-jun Chen; Xin Yan; Yu-qing Chen; Chao Zhao. Phytochemicals for Non-insulin Diabetes Mellitus: A Minireview on Plant-Derived Compounds Hypoglycemic Activity. J. Food Nutr. Sci. 2017, 5(2), 23-27. doi: 10.11648/j.jfns.20170502.11
AMA Style
Ming-jun Chen, Xin Yan, Yu-qing Chen, Chao Zhao. Phytochemicals for Non-insulin Diabetes Mellitus: A Minireview on Plant-Derived Compounds Hypoglycemic Activity. J Food Nutr Sci. 2017;5(2):23-27. doi: 10.11648/j.jfns.20170502.11
@article{10.11648/j.jfns.20170502.11, author = {Ming-jun Chen and Xin Yan and Yu-qing Chen and Chao Zhao}, title = {Phytochemicals for Non-insulin Diabetes Mellitus: A Minireview on Plant-Derived Compounds Hypoglycemic Activity}, journal = {Journal of Food and Nutrition Sciences}, volume = {5}, number = {2}, pages = {23-27}, doi = {10.11648/j.jfns.20170502.11}, url = {https://doi.org/10.11648/j.jfns.20170502.11}, eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jfns.20170502.11}, abstract = {Diabetes mellitus (DM), a group of chronic metabolic disorders characterized by hyperglycemia resulting from defects in insulin action and/or insulin secretion. It represents one of the main contributors to ill health and premature mortality worldwide and its prevalence has been rising during the last decades. Unfortunately, many antidiabetic agents for diabetes either have inadequate efficacy or significant mechanism-based side effects. A great deal of interest has been developed to the various natural bioactive compounds isolated and characterized from medicinal plants. This review focuses specifically on four nature phytochemicals such as polysaccharides, flavonoids, saponins and alkaloids whose properties are potencial to antidiabetic remedy.}, year = {2017} }
TY - JOUR T1 - Phytochemicals for Non-insulin Diabetes Mellitus: A Minireview on Plant-Derived Compounds Hypoglycemic Activity AU - Ming-jun Chen AU - Xin Yan AU - Yu-qing Chen AU - Chao Zhao Y1 - 2017/03/11 PY - 2017 N1 - https://doi.org/10.11648/j.jfns.20170502.11 DO - 10.11648/j.jfns.20170502.11 T2 - Journal of Food and Nutrition Sciences JF - Journal of Food and Nutrition Sciences JO - Journal of Food and Nutrition Sciences SP - 23 EP - 27 PB - Science Publishing Group SN - 2330-7293 UR - https://doi.org/10.11648/j.jfns.20170502.11 AB - Diabetes mellitus (DM), a group of chronic metabolic disorders characterized by hyperglycemia resulting from defects in insulin action and/or insulin secretion. It represents one of the main contributors to ill health and premature mortality worldwide and its prevalence has been rising during the last decades. Unfortunately, many antidiabetic agents for diabetes either have inadequate efficacy or significant mechanism-based side effects. A great deal of interest has been developed to the various natural bioactive compounds isolated and characterized from medicinal plants. This review focuses specifically on four nature phytochemicals such as polysaccharides, flavonoids, saponins and alkaloids whose properties are potencial to antidiabetic remedy. VL - 5 IS - 2 ER -