Background: Data on safety degree and anti–type 1 diabetic effects of Pterocarpus soyauxii Taub are known, but not on type 2 diabetes yet. Objective: To evaluate preventive effects of P. soyauxii Taub aqueous stem bark extract on dexamethasone–induced insulin resistance and oxidative stress in rat. Materials and Methods: Glucose-overloaded normal Wistar rats were administered with P. soyauxii aqueous plant extract at various doses (38–300 mg.kg) in a single administration. Then, dexamethasone (Dex)–induced insulin-resistant rats received sub-chronic daily administration of the plant extract (38–300 mg/kg) for 21 days. Glibenclamide (10 mg/kg) and metformin (200 mg/kg) were respectively used in each test as standard treatments. Fasting blood glucose was followed for over 3 h in acute test. In sub-chronic test, body weight was followed weekly, glycemia before and at the end of treatment, and insulin sensitivity and serum and tissue biochemical parameters evaluated at the end of treatment. Results: Single administration of the plant extract significantly reduced (p<0.05) the serum glucose level increase of glucose-overloaded rats at lower doses, compared to hyperglycemic control. Its prolonged administration with dexamethasone in normal rats prevented insulin-resistance at all doses (p<0.001) similarly to metformin, without decreasing the body weight loss. The extract also prevented significantly (p<0.001) dexamethasone-induced increased serum creatinine, triglyceride, LDL-cholesterol, and transaminases, and decreased total proteins and HDL-cholesterol. Moreover, it improved significantly (p<0.05 – p<0.001) tissues oxidative stress parameters. Conclusion: P. soyauxii Taub aqueous stem bark extract can prevent the onset of type 2 diabetes.
| Published in | Journal of Diseases and Medicinal Plants (Volume 8, Issue 1) |
| DOI | 10.11648/j.jdmp.20220801.11 |
| Page(s) | 1-12 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2022. Published by Science Publishing Group |
Dexamethasone, Insulin-resistance, Oxidative Stress, Prevention, Pterocarpus soyauxii Taub, Rat
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APA Style
Marie Claire Tchamadeu, Rosange Yefou Tsangue, Calvin Zangue Bogning, Christian Takoukam Ténézoguang, Patience Emambo, et al. (2022). Pterocarpus soyauxii Taub (Papilionaceae) Aqueous Stem Bark Extract Prevents Dexamethasone-induced Insulin Resistance and Oxidative Stress in Rat. Journal of Diseases and Medicinal Plants, 8(1), 1-12. https://doi.org/10.11648/j.jdmp.20220801.11
ACS Style
Marie Claire Tchamadeu; Rosange Yefou Tsangue; Calvin Zangue Bogning; Christian Takoukam Ténézoguang; Patience Emambo, et al. Pterocarpus soyauxii Taub (Papilionaceae) Aqueous Stem Bark Extract Prevents Dexamethasone-induced Insulin Resistance and Oxidative Stress in Rat. J. Dis. Med. Plants 2022, 8(1), 1-12. doi: 10.11648/j.jdmp.20220801.11
AMA Style
Marie Claire Tchamadeu, Rosange Yefou Tsangue, Calvin Zangue Bogning, Christian Takoukam Ténézoguang, Patience Emambo, et al. Pterocarpus soyauxii Taub (Papilionaceae) Aqueous Stem Bark Extract Prevents Dexamethasone-induced Insulin Resistance and Oxidative Stress in Rat. J Dis Med Plants. 2022;8(1):1-12. doi: 10.11648/j.jdmp.20220801.11
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Download@article{10.11648/j.jdmp.20220801.11,
author = {Marie Claire Tchamadeu and Rosange Yefou Tsangue and Calvin Zangue Bogning and Christian Takoukam Ténézoguang and Patience Emambo and Paul Désiré Djomeni Dzeufiet and Alain Bertrand Dongmo},
title = {Pterocarpus soyauxii Taub (Papilionaceae) Aqueous Stem Bark Extract Prevents Dexamethasone-induced Insulin Resistance and Oxidative Stress in Rat},
journal = {Journal of Diseases and Medicinal Plants},
volume = {8},
number = {1},
pages = {1-12},
doi = {10.11648/j.jdmp.20220801.11},
url = {https://doi.org/10.11648/j.jdmp.20220801.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jdmp.20220801.11},
abstract = {Background: Data on safety degree and anti–type 1 diabetic effects of Pterocarpus soyauxii Taub are known, but not on type 2 diabetes yet. Objective: To evaluate preventive effects of P. soyauxii Taub aqueous stem bark extract on dexamethasone–induced insulin resistance and oxidative stress in rat. Materials and Methods: Glucose-overloaded normal Wistar rats were administered with P. soyauxii aqueous plant extract at various doses (38–300 mg.kg) in a single administration. Then, dexamethasone (Dex)–induced insulin-resistant rats received sub-chronic daily administration of the plant extract (38–300 mg/kg) for 21 days. Glibenclamide (10 mg/kg) and metformin (200 mg/kg) were respectively used in each test as standard treatments. Fasting blood glucose was followed for over 3 h in acute test. In sub-chronic test, body weight was followed weekly, glycemia before and at the end of treatment, and insulin sensitivity and serum and tissue biochemical parameters evaluated at the end of treatment. Results: Single administration of the plant extract significantly reduced (pP. soyauxii Taub aqueous stem bark extract can prevent the onset of type 2 diabetes.},
year = {2022}
}
TY - JOUR T1 - Pterocarpus soyauxii Taub (Papilionaceae) Aqueous Stem Bark Extract Prevents Dexamethasone-induced Insulin Resistance and Oxidative Stress in Rat AU - Marie Claire Tchamadeu AU - Rosange Yefou Tsangue AU - Calvin Zangue Bogning AU - Christian Takoukam Ténézoguang AU - Patience Emambo AU - Paul Désiré Djomeni Dzeufiet AU - Alain Bertrand Dongmo Y1 - 2022/02/16 PY - 2022 N1 - https://doi.org/10.11648/j.jdmp.20220801.11 DO - 10.11648/j.jdmp.20220801.11 T2 - Journal of Diseases and Medicinal Plants JF - Journal of Diseases and Medicinal Plants JO - Journal of Diseases and Medicinal Plants SP - 1 EP - 12 PB - Science Publishing Group SN - 2469-8210 UR - https://doi.org/10.11648/j.jdmp.20220801.11 AB - Background: Data on safety degree and anti–type 1 diabetic effects of Pterocarpus soyauxii Taub are known, but not on type 2 diabetes yet. Objective: To evaluate preventive effects of P. soyauxii Taub aqueous stem bark extract on dexamethasone–induced insulin resistance and oxidative stress in rat. Materials and Methods: Glucose-overloaded normal Wistar rats were administered with P. soyauxii aqueous plant extract at various doses (38–300 mg.kg) in a single administration. Then, dexamethasone (Dex)–induced insulin-resistant rats received sub-chronic daily administration of the plant extract (38–300 mg/kg) for 21 days. Glibenclamide (10 mg/kg) and metformin (200 mg/kg) were respectively used in each test as standard treatments. Fasting blood glucose was followed for over 3 h in acute test. In sub-chronic test, body weight was followed weekly, glycemia before and at the end of treatment, and insulin sensitivity and serum and tissue biochemical parameters evaluated at the end of treatment. Results: Single administration of the plant extract significantly reduced (pP. soyauxii Taub aqueous stem bark extract can prevent the onset of type 2 diabetes. VL - 8 IS - 1 ER -
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