Effects of <i>Aegle marmelos</i> (L.) Methanolic Leaf Extracts on Cardiovascular Parameters in Diabetic Rats

Ravi Babu Birudu; Padmavathi Pamulapati; Manoharan Sathish Kumar

doi:doi:10.11648/j.jdmp.20200604.11

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Effects of Aegle marmelos (L.) Methanolic Leaf Extracts on Cardiovascular Parameters in Diabetic Rats

Ravi Babu Birudu, Padmavathi Pamulapati, Manoharan Sathish Kumar

Published in Journal of Diseases and Medicinal Plants (Volume 6, Issue 4)

Received: 15 September 2020 Accepted: 27 September 2020 Published: 7 October 2020

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Abstract

Aegle marmelos (L.) Correa is a widely found plant in India as well as in South Asia. For more than several centuries it is being widely used for its medicinal properties. The objective of the study was to evaluate the cardiovascular changes in alloxan induced diabetic rats treated with methanolic leaf extracts of Aegle marmelos. 5 treatment groups (namely control, diseased, low dose (100mg/kg), medium dose (250mg/kg) and high dose (500mg/kg) of methanolic leaf extracts were used in the study. The cardiovasculareffects were evaluated by the determination of Very-Low-Density Lipoprotein (VLDL), Serum Sialic Acid, Glutathione Peroxidase, Serum Catalase, Ascorbic acid, Sodium, Potassium, and Chloride levels. High dose treatment group showed significant decrease in Very-Low-Density Lipoprotein (VLDL), Serum Sialic Acid, Glutathione Peroxidase, Serum Catalase, Ascorbic acid, Sodium, Potassium, and Chloride levels when compared with the diseased treatment groups. Though Low and medium dose treated animals showed insignificant decrease in these cardiovascular parameters when compared with high dose treatment group as well as diseased group. The effects of high dose treatment on cardiovascular parameters were very significant as that of control group. Through the cardiovascular parameters it is evident that the highdose of methonolic leaf extract of Aegle marmelos can be used the treatment of diabetes and its cardiovascular complications.

Published in	Journal of Diseases and Medicinal Plants (Volume 6, Issue 4)
DOI	10.11648/j.jdmp.20200604.11
Page(s)	77-81
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Aegle marmelos, Rutaceae, Bael, Alloxan, Diabetes, Cardiovascular Parameters

References

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APA Style

Ravi Babu Birudu, Padmavathi Pamulapati, Manoharan Sathish Kumar. (2020). Effects of Aegle marmelos (L.) Methanolic Leaf Extracts on Cardiovascular Parameters in Diabetic Rats. Journal of Diseases and Medicinal Plants, 6(4), 77-81. https://doi.org/10.11648/j.jdmp.20200604.11

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ACS Style

Ravi Babu Birudu; Padmavathi Pamulapati; Manoharan Sathish Kumar. Effects of Aegle marmelos (L.) Methanolic Leaf Extracts on Cardiovascular Parameters in Diabetic Rats. J. Dis. Med. Plants 2020, 6(4), 77-81. doi: 10.11648/j.jdmp.20200604.11

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AMA Style

Ravi Babu Birudu, Padmavathi Pamulapati, Manoharan Sathish Kumar. Effects of Aegle marmelos (L.) Methanolic Leaf Extracts on Cardiovascular Parameters in Diabetic Rats. J Dis Med Plants. 2020;6(4):77-81. doi: 10.11648/j.jdmp.20200604.11

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@article{10.11648/j.jdmp.20200604.11,
  author = {Ravi Babu Birudu and Padmavathi Pamulapati and Manoharan Sathish Kumar},
  title = {Effects of Aegle marmelos (L.) Methanolic Leaf Extracts on Cardiovascular Parameters in Diabetic Rats},
  journal = {Journal of Diseases and Medicinal Plants},
  volume = {6},
  number = {4},
  pages = {77-81},
  doi = {10.11648/j.jdmp.20200604.11},
  url = {https://doi.org/10.11648/j.jdmp.20200604.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jdmp.20200604.11},
  abstract = {Aegle marmelos (L.) Correa is a widely found plant in India as well as in South Asia. For more than several centuries it is being widely used for its medicinal properties. The objective of the study was to evaluate the cardiovascular changes in alloxan induced diabetic rats treated with methanolic leaf extracts of Aegle marmelos. 5 treatment groups (namely control, diseased, low dose (100mg/kg), medium dose (250mg/kg) and high dose (500mg/kg) of methanolic leaf extracts were used in the study. The cardiovasculareffects were evaluated by the determination of Very-Low-Density Lipoprotein (VLDL), Serum Sialic Acid, Glutathione Peroxidase, Serum Catalase, Ascorbic acid, Sodium, Potassium, and Chloride levels. High dose treatment group showed significant decrease in Very-Low-Density Lipoprotein (VLDL), Serum Sialic Acid, Glutathione Peroxidase, Serum Catalase, Ascorbic acid, Sodium, Potassium, and Chloride levels when compared with the diseased treatment groups. Though Low and medium dose treated animals showed insignificant decrease in these cardiovascular parameters when compared with high dose treatment group as well as diseased group. The effects of high dose treatment on cardiovascular parameters were very significant as that of control group. Through the cardiovascular parameters it is evident that the highdose of methonolic leaf extract of Aegle marmelos can be used the treatment of diabetes and its cardiovascular complications.},
 year = {2020}
}

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TY  - JOUR
T1  - Effects of Aegle marmelos (L.) Methanolic Leaf Extracts on Cardiovascular Parameters in Diabetic Rats
AU  - Ravi Babu Birudu
AU  - Padmavathi Pamulapati
AU  - Manoharan Sathish Kumar
Y1  - 2020/10/07
PY  - 2020
N1  - https://doi.org/10.11648/j.jdmp.20200604.11
DO  - 10.11648/j.jdmp.20200604.11
T2  - Journal of Diseases and Medicinal Plants
JF  - Journal of Diseases and Medicinal Plants
JO  - Journal of Diseases and Medicinal Plants
SP  - 77
EP  - 81
PB  - Science Publishing Group
SN  - 2469-8210
UR  - https://doi.org/10.11648/j.jdmp.20200604.11
AB  - Aegle marmelos (L.) Correa is a widely found plant in India as well as in South Asia. For more than several centuries it is being widely used for its medicinal properties. The objective of the study was to evaluate the cardiovascular changes in alloxan induced diabetic rats treated with methanolic leaf extracts of Aegle marmelos. 5 treatment groups (namely control, diseased, low dose (100mg/kg), medium dose (250mg/kg) and high dose (500mg/kg) of methanolic leaf extracts were used in the study. The cardiovasculareffects were evaluated by the determination of Very-Low-Density Lipoprotein (VLDL), Serum Sialic Acid, Glutathione Peroxidase, Serum Catalase, Ascorbic acid, Sodium, Potassium, and Chloride levels. High dose treatment group showed significant decrease in Very-Low-Density Lipoprotein (VLDL), Serum Sialic Acid, Glutathione Peroxidase, Serum Catalase, Ascorbic acid, Sodium, Potassium, and Chloride levels when compared with the diseased treatment groups. Though Low and medium dose treated animals showed insignificant decrease in these cardiovascular parameters when compared with high dose treatment group as well as diseased group. The effects of high dose treatment on cardiovascular parameters were very significant as that of control group. Through the cardiovascular parameters it is evident that the highdose of methonolic leaf extract of Aegle marmelos can be used the treatment of diabetes and its cardiovascular complications.
VL  - 6
IS  - 4
ER  -

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Author Information

Ravi Babu Birudu

Department of Zoology & Aquaculture, Acharya Nagarjuna University, Andhra Pradesh, India
Padmavathi Pamulapati

Department of Zoology & Aquaculture, Acharya Nagarjuna University, Andhra Pradesh, India
Manoharan Sathish Kumar

Department of Pharmacology, Bapatla College of Pharmacy, Bapatla, Andhra Pradesh, India

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Ravi Babu Birudu, Padmavathi Pamulapati, Manoharan Sathish Kumar. (2020). Effects of Aegle marmelos (L.) Methanolic Leaf Extracts on Cardiovascular Parameters in Diabetic Rats. Journal of Diseases and Medicinal Plants, 6(4), 77-81. https://doi.org/10.11648/j.jdmp.20200604.11

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ACS Style

Ravi Babu Birudu; Padmavathi Pamulapati; Manoharan Sathish Kumar. Effects of Aegle marmelos (L.) Methanolic Leaf Extracts on Cardiovascular Parameters in Diabetic Rats. J. Dis. Med. Plants 2020, 6(4), 77-81. doi: 10.11648/j.jdmp.20200604.11

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AMA Style

Ravi Babu Birudu, Padmavathi Pamulapati, Manoharan Sathish Kumar. Effects of Aegle marmelos (L.) Methanolic Leaf Extracts on Cardiovascular Parameters in Diabetic Rats. J Dis Med Plants. 2020;6(4):77-81. doi: 10.11648/j.jdmp.20200604.11

Copy | Download

@article{10.11648/j.jdmp.20200604.11,
  author = {Ravi Babu Birudu and Padmavathi Pamulapati and Manoharan Sathish Kumar},
  title = {Effects of Aegle marmelos (L.) Methanolic Leaf Extracts on Cardiovascular Parameters in Diabetic Rats},
  journal = {Journal of Diseases and Medicinal Plants},
  volume = {6},
  number = {4},
  pages = {77-81},
  doi = {10.11648/j.jdmp.20200604.11},
  url = {https://doi.org/10.11648/j.jdmp.20200604.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jdmp.20200604.11},
  abstract = {Aegle marmelos (L.) Correa is a widely found plant in India as well as in South Asia. For more than several centuries it is being widely used for its medicinal properties. The objective of the study was to evaluate the cardiovascular changes in alloxan induced diabetic rats treated with methanolic leaf extracts of Aegle marmelos. 5 treatment groups (namely control, diseased, low dose (100mg/kg), medium dose (250mg/kg) and high dose (500mg/kg) of methanolic leaf extracts were used in the study. The cardiovasculareffects were evaluated by the determination of Very-Low-Density Lipoprotein (VLDL), Serum Sialic Acid, Glutathione Peroxidase, Serum Catalase, Ascorbic acid, Sodium, Potassium, and Chloride levels. High dose treatment group showed significant decrease in Very-Low-Density Lipoprotein (VLDL), Serum Sialic Acid, Glutathione Peroxidase, Serum Catalase, Ascorbic acid, Sodium, Potassium, and Chloride levels when compared with the diseased treatment groups. Though Low and medium dose treated animals showed insignificant decrease in these cardiovascular parameters when compared with high dose treatment group as well as diseased group. The effects of high dose treatment on cardiovascular parameters were very significant as that of control group. Through the cardiovascular parameters it is evident that the highdose of methonolic leaf extract of Aegle marmelos can be used the treatment of diabetes and its cardiovascular complications.},
 year = {2020}
}

Copy | Download

TY  - JOUR
T1  - Effects of Aegle marmelos (L.) Methanolic Leaf Extracts on Cardiovascular Parameters in Diabetic Rats
AU  - Ravi Babu Birudu
AU  - Padmavathi Pamulapati
AU  - Manoharan Sathish Kumar
Y1  - 2020/10/07
PY  - 2020
N1  - https://doi.org/10.11648/j.jdmp.20200604.11
DO  - 10.11648/j.jdmp.20200604.11
T2  - Journal of Diseases and Medicinal Plants
JF  - Journal of Diseases and Medicinal Plants
JO  - Journal of Diseases and Medicinal Plants
SP  - 77
EP  - 81
PB  - Science Publishing Group
SN  - 2469-8210
UR  - https://doi.org/10.11648/j.jdmp.20200604.11
AB  - Aegle marmelos (L.) Correa is a widely found plant in India as well as in South Asia. For more than several centuries it is being widely used for its medicinal properties. The objective of the study was to evaluate the cardiovascular changes in alloxan induced diabetic rats treated with methanolic leaf extracts of Aegle marmelos. 5 treatment groups (namely control, diseased, low dose (100mg/kg), medium dose (250mg/kg) and high dose (500mg/kg) of methanolic leaf extracts were used in the study. The cardiovasculareffects were evaluated by the determination of Very-Low-Density Lipoprotein (VLDL), Serum Sialic Acid, Glutathione Peroxidase, Serum Catalase, Ascorbic acid, Sodium, Potassium, and Chloride levels. High dose treatment group showed significant decrease in Very-Low-Density Lipoprotein (VLDL), Serum Sialic Acid, Glutathione Peroxidase, Serum Catalase, Ascorbic acid, Sodium, Potassium, and Chloride levels when compared with the diseased treatment groups. Though Low and medium dose treated animals showed insignificant decrease in these cardiovascular parameters when compared with high dose treatment group as well as diseased group. The effects of high dose treatment on cardiovascular parameters were very significant as that of control group. Through the cardiovascular parameters it is evident that the highdose of methonolic leaf extract of Aegle marmelos can be used the treatment of diabetes and its cardiovascular complications.
VL  - 6
IS  - 4
ER  -

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