Systemic Immunological Responses Among Dental Infection Patients

Zainab Khudher Ahmad Al Mahdi; Fatima Malik Abood

doi:doi:10.11648/j.iji.20210901.12

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Systemic Immunological Responses Among Dental Infection Patients

Zainab Khudher Ahmad Al Mahdi, Fatima Malik Abood

Published in International Journal of Immunology (Volume 9, Issue 1)

Received: 5 December 2020 Accepted: 12 January 2021 Published: 22 January 2021

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Abstract

Dental infections are common health problems, evaluating of some systemic immunological responses are the aim of our study. Our study considered isolation of dental infection bacteria and quantitative evaluation of serum. IgA, IL-4, IL-7 and CD4 and CD8 molecules among dental plaque patients and control group. Oral bacteria from dental infection patients were isolated in appropriate media and diagnosed by biochemical tests and in vitro quantitative determination of serum IgA, IL-4, IL-7 and CD4 and CD8 molecules using ELISA technique. Single and mixed bacterial isolates were noted, mixed infection were (59.25%), the nature of bacteria was Gram positive cocci Streptococcus viridans, Streptococcus pyogenes and Staphylococcus aureus, and Lactocacilli spps, in addition to Gram negative rods black- pigmented bacteria, Klebsilla pneumonia, and Esherishia coli. Serum IgA was higher in patients (368.8±182.5) ng\ml than in control group (319.92±79.26) ng\ml. Serum IL-4 was higher patients (285.33±86.12) pg/ml than in control group (257.7±94.14) pg\ml. Serum IL-7 was higher in control group (19.59±4.14) pg/ml than in dental plaque patients (17.98±3.18) pg /ml. Serum CD4 molecules was higher in control group (1.371±0.5242) ng/ml than in dental plaque patients (1.326±0.1292) ng/ml. Serum CD8 molecules shows non-significant elevation in patients group 0.5825±0.02717 (ng\ml) than in control group 0.51±0.01643 (ng\ml) P≤0.05. Mean of the CD4/CD8 ratio was higher 2.783±1.126 in control group while it was 2.355±0.24 in dental plaque patients, however the differences were non-significant (P≤0.05). The present study conclude that the bacteria isolated from dental infection patients were mixed more than single infection, there were non-significant elevation in IgA, IL-4, and CD8 in patients while IL-7 and CD4 was lower in patients group than in control group, while CD4\CD8 ratio were lower in patients group, these result reflect the fact that mucosal antigen induce systemic tolerance to some extent since these bacteria present in oral cavity in early childhood. Therefor removing these bacteria always the best way to prevent such infections.

Published in	International Journal of Immunology (Volume 9, Issue 1)
DOI	10.11648/j.iji.20210901.12
Page(s)	6-12
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Dental Infection, Immune Response, Cytokine, Oral Bacteria

References

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APA Style

Zainab Khudher Ahmad Al Mahdi, Fatima Malik Abood. (2021). Systemic Immunological Responses Among Dental Infection Patients. International Journal of Immunology, 9(1), 6-12. https://doi.org/10.11648/j.iji.20210901.12

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Zainab Khudher Ahmad Al Mahdi; Fatima Malik Abood. Systemic Immunological Responses Among Dental Infection Patients. Int. J. Immunol. 2021, 9(1), 6-12. doi: 10.11648/j.iji.20210901.12

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AMA Style

Zainab Khudher Ahmad Al Mahdi, Fatima Malik Abood. Systemic Immunological Responses Among Dental Infection Patients. Int J Immunol. 2021;9(1):6-12. doi: 10.11648/j.iji.20210901.12

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@article{10.11648/j.iji.20210901.12,
  author = {Zainab Khudher Ahmad Al Mahdi and Fatima Malik Abood},
  title = {Systemic Immunological Responses Among Dental Infection Patients},
  journal = {International Journal of Immunology},
  volume = {9},
  number = {1},
  pages = {6-12},
  doi = {10.11648/j.iji.20210901.12},
  url = {https://doi.org/10.11648/j.iji.20210901.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.iji.20210901.12},
  abstract = {Dental infections are common health problems, evaluating of some systemic immunological responses are the aim of our study. Our study considered isolation of dental infection bacteria and quantitative evaluation of serum. IgA, IL-4, IL-7 and CD4 and CD8 molecules among dental plaque patients and control group. Oral bacteria from dental infection patients were isolated in appropriate media and diagnosed by biochemical tests and in vitro quantitative determination of serum IgA, IL-4, IL-7 and CD4 and CD8 molecules using ELISA technique. Single and mixed bacterial isolates were noted, mixed infection were (59.25%), the nature of bacteria was Gram positive cocci Streptococcus viridans, Streptococcus pyogenes and Staphylococcus aureus, and Lactocacilli spps, in addition to Gram negative rods black- pigmented bacteria, Klebsilla pneumonia, and Esherishia coli. Serum IgA was higher in patients (368.8±182.5) ng\ml than in control group (319.92±79.26) ng\ml. Serum IL-4 was higher patients (285.33±86.12) pg/ml than in control group (257.7±94.14) pg\ml. Serum IL-7 was higher in control group (19.59±4.14) pg/ml than in dental plaque patients (17.98±3.18) pg /ml. Serum CD4 molecules was higher in control group (1.371±0.5242) ng/ml than in dental plaque patients (1.326±0.1292) ng/ml. Serum CD8 molecules shows non-significant elevation in patients group 0.5825±0.02717 (ng\ml) than in control group 0.51±0.01643 (ng\ml) P≤0.05. Mean of the CD4/CD8 ratio was higher 2.783±1.126 in control group while it was 2.355±0.24 in dental plaque patients, however the differences were non-significant (P≤0.05). The present study conclude that the bacteria isolated from dental infection patients were mixed more than single infection, there were non-significant elevation in IgA, IL-4, and CD8 in patients while IL-7 and CD4 was lower in patients group than in control group, while CD4\CD8 ratio were lower in patients group, these result reflect the fact that mucosal antigen induce systemic tolerance to some extent since these bacteria present in oral cavity in early childhood. Therefor removing these bacteria always the best way to prevent such infections.},
 year = {2021}
}

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TY  - JOUR
T1  - Systemic Immunological Responses Among Dental Infection Patients
AU  - Zainab Khudher Ahmad Al Mahdi
AU  - Fatima Malik Abood
Y1  - 2021/01/22
PY  - 2021
N1  - https://doi.org/10.11648/j.iji.20210901.12
DO  - 10.11648/j.iji.20210901.12
T2  - International Journal of Immunology
JF  - International Journal of Immunology
JO  - International Journal of Immunology
SP  - 6
EP  - 12
PB  - Science Publishing Group
SN  - 2329-1753
UR  - https://doi.org/10.11648/j.iji.20210901.12
AB  - Dental infections are common health problems, evaluating of some systemic immunological responses are the aim of our study. Our study considered isolation of dental infection bacteria and quantitative evaluation of serum. IgA, IL-4, IL-7 and CD4 and CD8 molecules among dental plaque patients and control group. Oral bacteria from dental infection patients were isolated in appropriate media and diagnosed by biochemical tests and in vitro quantitative determination of serum IgA, IL-4, IL-7 and CD4 and CD8 molecules using ELISA technique. Single and mixed bacterial isolates were noted, mixed infection were (59.25%), the nature of bacteria was Gram positive cocci Streptococcus viridans, Streptococcus pyogenes and Staphylococcus aureus, and Lactocacilli spps, in addition to Gram negative rods black- pigmented bacteria, Klebsilla pneumonia, and Esherishia coli. Serum IgA was higher in patients (368.8±182.5) ng\ml than in control group (319.92±79.26) ng\ml. Serum IL-4 was higher patients (285.33±86.12) pg/ml than in control group (257.7±94.14) pg\ml. Serum IL-7 was higher in control group (19.59±4.14) pg/ml than in dental plaque patients (17.98±3.18) pg /ml. Serum CD4 molecules was higher in control group (1.371±0.5242) ng/ml than in dental plaque patients (1.326±0.1292) ng/ml. Serum CD8 molecules shows non-significant elevation in patients group 0.5825±0.02717 (ng\ml) than in control group 0.51±0.01643 (ng\ml) P≤0.05. Mean of the CD4/CD8 ratio was higher 2.783±1.126 in control group while it was 2.355±0.24 in dental plaque patients, however the differences were non-significant (P≤0.05). The present study conclude that the bacteria isolated from dental infection patients were mixed more than single infection, there were non-significant elevation in IgA, IL-4, and CD8 in patients while IL-7 and CD4 was lower in patients group than in control group, while CD4\CD8 ratio were lower in patients group, these result reflect the fact that mucosal antigen induce systemic tolerance to some extent since these bacteria present in oral cavity in early childhood. Therefor removing these bacteria always the best way to prevent such infections.
VL  - 9
IS  - 1
ER  -

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Author Information

Zainab Khudher Ahmad Al Mahdi

Department of Microbiology, College of Dentistry, University of Babylon, Hilla City, Iraq
Fatima Malik Abood

Department of Microbiology, College of Dentistry, University of Babylon, Hilla City, Iraq

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APA Style

Zainab Khudher Ahmad Al Mahdi, Fatima Malik Abood. (2021). Systemic Immunological Responses Among Dental Infection Patients. International Journal of Immunology, 9(1), 6-12. https://doi.org/10.11648/j.iji.20210901.12

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ACS Style

Zainab Khudher Ahmad Al Mahdi; Fatima Malik Abood. Systemic Immunological Responses Among Dental Infection Patients. Int. J. Immunol. 2021, 9(1), 6-12. doi: 10.11648/j.iji.20210901.12

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AMA Style

Zainab Khudher Ahmad Al Mahdi, Fatima Malik Abood. Systemic Immunological Responses Among Dental Infection Patients. Int J Immunol. 2021;9(1):6-12. doi: 10.11648/j.iji.20210901.12

Copy | Download

@article{10.11648/j.iji.20210901.12,
  author = {Zainab Khudher Ahmad Al Mahdi and Fatima Malik Abood},
  title = {Systemic Immunological Responses Among Dental Infection Patients},
  journal = {International Journal of Immunology},
  volume = {9},
  number = {1},
  pages = {6-12},
  doi = {10.11648/j.iji.20210901.12},
  url = {https://doi.org/10.11648/j.iji.20210901.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.iji.20210901.12},
  abstract = {Dental infections are common health problems, evaluating of some systemic immunological responses are the aim of our study. Our study considered isolation of dental infection bacteria and quantitative evaluation of serum. IgA, IL-4, IL-7 and CD4 and CD8 molecules among dental plaque patients and control group. Oral bacteria from dental infection patients were isolated in appropriate media and diagnosed by biochemical tests and in vitro quantitative determination of serum IgA, IL-4, IL-7 and CD4 and CD8 molecules using ELISA technique. Single and mixed bacterial isolates were noted, mixed infection were (59.25%), the nature of bacteria was Gram positive cocci Streptococcus viridans, Streptococcus pyogenes and Staphylococcus aureus, and Lactocacilli spps, in addition to Gram negative rods black- pigmented bacteria, Klebsilla pneumonia, and Esherishia coli. Serum IgA was higher in patients (368.8±182.5) ng\ml than in control group (319.92±79.26) ng\ml. Serum IL-4 was higher patients (285.33±86.12) pg/ml than in control group (257.7±94.14) pg\ml. Serum IL-7 was higher in control group (19.59±4.14) pg/ml than in dental plaque patients (17.98±3.18) pg /ml. Serum CD4 molecules was higher in control group (1.371±0.5242) ng/ml than in dental plaque patients (1.326±0.1292) ng/ml. Serum CD8 molecules shows non-significant elevation in patients group 0.5825±0.02717 (ng\ml) than in control group 0.51±0.01643 (ng\ml) P≤0.05. Mean of the CD4/CD8 ratio was higher 2.783±1.126 in control group while it was 2.355±0.24 in dental plaque patients, however the differences were non-significant (P≤0.05). The present study conclude that the bacteria isolated from dental infection patients were mixed more than single infection, there were non-significant elevation in IgA, IL-4, and CD8 in patients while IL-7 and CD4 was lower in patients group than in control group, while CD4\CD8 ratio were lower in patients group, these result reflect the fact that mucosal antigen induce systemic tolerance to some extent since these bacteria present in oral cavity in early childhood. Therefor removing these bacteria always the best way to prevent such infections.},
 year = {2021}
}

Copy | Download

TY  - JOUR
T1  - Systemic Immunological Responses Among Dental Infection Patients
AU  - Zainab Khudher Ahmad Al Mahdi
AU  - Fatima Malik Abood
Y1  - 2021/01/22
PY  - 2021
N1  - https://doi.org/10.11648/j.iji.20210901.12
DO  - 10.11648/j.iji.20210901.12
T2  - International Journal of Immunology
JF  - International Journal of Immunology
JO  - International Journal of Immunology
SP  - 6
EP  - 12
PB  - Science Publishing Group
SN  - 2329-1753
UR  - https://doi.org/10.11648/j.iji.20210901.12
AB  - Dental infections are common health problems, evaluating of some systemic immunological responses are the aim of our study. Our study considered isolation of dental infection bacteria and quantitative evaluation of serum. IgA, IL-4, IL-7 and CD4 and CD8 molecules among dental plaque patients and control group. Oral bacteria from dental infection patients were isolated in appropriate media and diagnosed by biochemical tests and in vitro quantitative determination of serum IgA, IL-4, IL-7 and CD4 and CD8 molecules using ELISA technique. Single and mixed bacterial isolates were noted, mixed infection were (59.25%), the nature of bacteria was Gram positive cocci Streptococcus viridans, Streptococcus pyogenes and Staphylococcus aureus, and Lactocacilli spps, in addition to Gram negative rods black- pigmented bacteria, Klebsilla pneumonia, and Esherishia coli. Serum IgA was higher in patients (368.8±182.5) ng\ml than in control group (319.92±79.26) ng\ml. Serum IL-4 was higher patients (285.33±86.12) pg/ml than in control group (257.7±94.14) pg\ml. Serum IL-7 was higher in control group (19.59±4.14) pg/ml than in dental plaque patients (17.98±3.18) pg /ml. Serum CD4 molecules was higher in control group (1.371±0.5242) ng/ml than in dental plaque patients (1.326±0.1292) ng/ml. Serum CD8 molecules shows non-significant elevation in patients group 0.5825±0.02717 (ng\ml) than in control group 0.51±0.01643 (ng\ml) P≤0.05. Mean of the CD4/CD8 ratio was higher 2.783±1.126 in control group while it was 2.355±0.24 in dental plaque patients, however the differences were non-significant (P≤0.05). The present study conclude that the bacteria isolated from dental infection patients were mixed more than single infection, there were non-significant elevation in IgA, IL-4, and CD8 in patients while IL-7 and CD4 was lower in patients group than in control group, while CD4\CD8 ratio were lower in patients group, these result reflect the fact that mucosal antigen induce systemic tolerance to some extent since these bacteria present in oral cavity in early childhood. Therefor removing these bacteria always the best way to prevent such infections.
VL  - 9
IS  - 1
ER  -

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