Relationship Between Immunological Factors and Hemarthrosis in Hemophiliacs in Antananarivo Madagascar

Rakotomalala Toky Randriamahazo; Zoliarisoa Ramihajamanana; Anjatiana Annick Raherinaivo; Miora Rasamindrakotroka; Davidra Rajaonatahina; Olivat Rakoto Alson; Andry Rasamindrakotroka

doi:doi:10.11648/j.iji.20190704.13

Relationship Between Immunological Factors and Hemarthrosis in Hemophiliacs in Antananarivo Madagascar

Rakotomalala Toky Randriamahazo, Zoliarisoa Ramihajamanana, Anjatiana Annick Raherinaivo, Miora Rasamindrakotroka, Davidra Rajaonatahina, Olivat Rakoto Alson, Andry Rasamindrakotroka

Published in International Journal of Immunology (Volume 7, Issue 4)

Received: 14 January 2020 Accepted: 27 January 2020 Published: 13 February 2020

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Abstract

Currently, there are 122 hemophiliacs in Madagascar followed at the hemophiliac treatment center of the Joseph Ravoahangy Andrianavalona University Hospital Center (JRA UHC), 55 present hemophilia B and 67 of hemophilia A. In hemophilic patients, the diagnosis of hemarthrosis is obviousin front of articular inflammation. It’s important to determinate the main risk factor as well as predisposition indicators tothe occurrence of "spontaneous" hemarthrosis in hemophiliacsfor prevention andearly careanticipation. In this prospect, the search for potentpredisposition indicator such as immunologicalfactorsis important. This is a case control study on all hemophiliacs seen at (JRA UHC) with hemarthrosis for 7 months. We have descriptively studied the qualitative and quantitative variables consisting in the determination of rheumatoid factors (RF) and the titer of antistreptolysin O (ASLO). Then we studied the statistical correlations. During the study period, we included 30 hemophiliac subjects with hemarthrosis who had an average age of 16.8 years. We had as much hemophiliac A as hemophiliac B; 23.3% practiced sporting activity; 10% had history of angina, involvement of the knee joint predominated at 44% (left 24%). RF positive were present in 26.7% (8/30) predominant in hemophiliacs aged from 19 to 36 (62.5%). The ASLO positive titer was found in 43.3% (13/30) predominant in children from 5 to 13 years (38.5%) with a maximum rate of 1600IU / l. There was no significant relationship between the positivity of the parameters with the presence or absence of hemarthrosis with a value of p = 0.231 and p = 0.06 respectively (p > 0.05). A large number of hemophiliac patients had a combination of clinical and biological signs in relation to diagnose rheumatic fever and rheumatoid arthritis which must be monitored as this could predict the occurrence in the short and medium term of these diseases which could be mistaken for hemarthrosisrelated to hemophilia.

Published in	International Journal of Immunology (Volume 7, Issue 4)
DOI	10.11648/j.iji.20190704.13
Page(s)	47-50
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Hemophilia, Hemarthrosis, Rheumatoid Factor, Antistreptolysin O

References

[1]	Srivastava, A., Brewer, A. K., Mauser‐Bunschoten, E. P., Key, N. S., Kitchen, S., Llinas, A., Street, A. (2013). Guidelines for the management of hemophilia. Haemophilia, 19 (1), e1-e47.
[2]	Dajani, A. S., Ayoub, E., Bierman, F. Z., Bisno, A. L., Denny, F. W., Durack, D. T., &Karchmer, A. W. (1992). Guidelines for the diagnosis of rheumatic fever: Jones criteria, 1992 update. Jama, 268 (15), 2069-2073.
[3]	Peters MJL, Symmons DPM, McCarey D. EULAR evidence-based recommendations for cardiovascular risk management in patients with rheumatoid arthritis and other forms of inflammatory arthritis. Ann Rheum Dis. 2010; 69: 325–31.
[4]	D. Morillon, N. Boutry, X. Demondion, B. Duquesnoy, A. Cotten. Lésions musculosquelettiques dans l’hémophilie. EMC-Radiologie. 2004; 1: 283–292.
[5]	Alcalay, M., & Deplas, A. (2002). Prise en charge rhumatologique de l’hémophilie (première partie: manifestations articulaires). Revue du rhumatisme, 69 (9), 868-876.
[6]	Martins, Thomas B., Hoffman, James L., Augustine, Nancy H., et al. Comprehensive analysis of antibody responses to streptococcal and tissue antigens in patients with acute rheumatic fever. International immunology, 2008, vol. 20, no 3, p. 445-452.
[7]	Rajaonarison LHNON, FH Rabemanorintsoa, FR Ravelonarivo, OA RakotoAlson, A Ahmad. Profil épidemio-clinique et radiologique des atteintes ostéo-articulaires deshémophiles à Madagascar. Pan AfricanMedical Journal. 2014; 19: 287.
[8]	Terao C, Yamakawa N, Yano K, Markusse YM, Ikari K, Yoshida S, et al. Rheumatoid Factor Is Associated With the Distribution of Hand Joint Destruction in Rheumatoid Arthritis. Arthritis & Rheumatology. 2015; 67 (12): 3113–23.
[9]	Orge E, Çefle A, Yazıcı A, Gürel-Polat N, Hulagu S. The positivity of rheumatoid factor and anti-cyclic citrullinated peptide antibody in non-arthritic patients with chronic hepatitis C infection. Rheumatol Int. 2010; 30: 485–8.
[10]	Deane KD, Norris JM, Holers VM. Preclinical rheumatoid arthritis: identification, evaluation, and future directions for investigation. Rheum Dis Clin North Am. 2010; 36 (2): 213–41.
[11]	Remus CR, Castillo-Ortiz JD, Aguilar-Lozano L, Padilla-Ibarra J, Sandoval-Castro C, Vargas-Serafin CO, et al. Autoantibodies in Prediction of the Development of Rheumatoid Arthritis Among Healthy Relatives of Patients With the Disease. Arthritis Rheum. 2015; 67 (11): 2837–44.
[12]	Ben-chetrit E, Moses AE, Agmon-levin N, Block C. Serum levels of antistreptolysin O antibodies : their role in evaluating rheumatic diseases. International journal of rheumatic diseases. 2012; 15 (1): 78–85.

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Rakotomalala Toky Randriamahazo, Zoliarisoa Ramihajamanana, Anjatiana Annick Raherinaivo, Miora Rasamindrakotroka, Davidra Rajaonatahina, et al. (2020). Relationship Between Immunological Factors and Hemarthrosis in Hemophiliacs in Antananarivo Madagascar. International Journal of Immunology, 7(4), 47-50. https://doi.org/10.11648/j.iji.20190704.13

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ACS Style

Rakotomalala Toky Randriamahazo; Zoliarisoa Ramihajamanana; Anjatiana Annick Raherinaivo; Miora Rasamindrakotroka; Davidra Rajaonatahina, et al. Relationship Between Immunological Factors and Hemarthrosis in Hemophiliacs in Antananarivo Madagascar. Int. J. Immunol. 2020, 7(4), 47-50. doi: 10.11648/j.iji.20190704.13

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AMA Style

Rakotomalala Toky Randriamahazo, Zoliarisoa Ramihajamanana, Anjatiana Annick Raherinaivo, Miora Rasamindrakotroka, Davidra Rajaonatahina, et al. Relationship Between Immunological Factors and Hemarthrosis in Hemophiliacs in Antananarivo Madagascar. Int J Immunol. 2020;7(4):47-50. doi: 10.11648/j.iji.20190704.13

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@article{10.11648/j.iji.20190704.13,
  author = {Rakotomalala Toky Randriamahazo and Zoliarisoa Ramihajamanana and Anjatiana Annick Raherinaivo and Miora Rasamindrakotroka and Davidra Rajaonatahina and Olivat Rakoto Alson and Andry Rasamindrakotroka},
  title = {Relationship Between Immunological Factors and Hemarthrosis in Hemophiliacs in Antananarivo Madagascar},
  journal = {International Journal of Immunology},
  volume = {7},
  number = {4},
  pages = {47-50},
  doi = {10.11648/j.iji.20190704.13},
  url = {https://doi.org/10.11648/j.iji.20190704.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.iji.20190704.13},
  abstract = {Currently, there are 122 hemophiliacs in Madagascar followed at the hemophiliac treatment center of the Joseph Ravoahangy Andrianavalona University Hospital Center (JRA UHC), 55 present hemophilia B and 67 of hemophilia A. In hemophilic patients, the diagnosis of hemarthrosis is obviousin front of articular inflammation. It’s important to determinate the main risk factor as well as predisposition indicators tothe occurrence of "spontaneous" hemarthrosis in hemophiliacsfor prevention andearly careanticipation. In this prospect, the search for potentpredisposition indicator such as immunologicalfactorsis important. This is a case control study on all hemophiliacs seen at (JRA UHC) with hemarthrosis for 7 months. We have descriptively studied the qualitative and quantitative variables consisting in the determination of rheumatoid factors (RF) and the titer of antistreptolysin O (ASLO). Then we studied the statistical correlations. During the study period, we included 30 hemophiliac subjects with hemarthrosis who had an average age of 16.8 years. We had as much hemophiliac A as hemophiliac B; 23.3% practiced sporting activity; 10% had history of angina, involvement of the knee joint predominated at 44% (left 24%). RF positive were present in 26.7% (8/30) predominant in hemophiliacs aged from 19 to 36 (62.5%). The ASLO positive titer was found in 43.3% (13/30) predominant in children from 5 to 13 years (38.5%) with a maximum rate of 1600IU / l. There was no significant relationship between the positivity of the parameters with the presence or absence of hemarthrosis with a value of p = 0.231 and p = 0.06 respectively (p > 0.05). A large number of hemophiliac patients had a combination of clinical and biological signs in relation to diagnose rheumatic fever and rheumatoid arthritis which must be monitored as this could predict the occurrence in the short and medium term of these diseases which could be mistaken for hemarthrosisrelated to hemophilia.},
 year = {2020}
}

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TY  - JOUR
T1  - Relationship Between Immunological Factors and Hemarthrosis in Hemophiliacs in Antananarivo Madagascar
AU  - Rakotomalala Toky Randriamahazo
AU  - Zoliarisoa Ramihajamanana
AU  - Anjatiana Annick Raherinaivo
AU  - Miora Rasamindrakotroka
AU  - Davidra Rajaonatahina
AU  - Olivat Rakoto Alson
AU  - Andry Rasamindrakotroka
Y1  - 2020/02/13
PY  - 2020
N1  - https://doi.org/10.11648/j.iji.20190704.13
DO  - 10.11648/j.iji.20190704.13
T2  - International Journal of Immunology
JF  - International Journal of Immunology
JO  - International Journal of Immunology
SP  - 47
EP  - 50
PB  - Science Publishing Group
SN  - 2329-1753
UR  - https://doi.org/10.11648/j.iji.20190704.13
AB  - Currently, there are 122 hemophiliacs in Madagascar followed at the hemophiliac treatment center of the Joseph Ravoahangy Andrianavalona University Hospital Center (JRA UHC), 55 present hemophilia B and 67 of hemophilia A. In hemophilic patients, the diagnosis of hemarthrosis is obviousin front of articular inflammation. It’s important to determinate the main risk factor as well as predisposition indicators tothe occurrence of "spontaneous" hemarthrosis in hemophiliacsfor prevention andearly careanticipation. In this prospect, the search for potentpredisposition indicator such as immunologicalfactorsis important. This is a case control study on all hemophiliacs seen at (JRA UHC) with hemarthrosis for 7 months. We have descriptively studied the qualitative and quantitative variables consisting in the determination of rheumatoid factors (RF) and the titer of antistreptolysin O (ASLO). Then we studied the statistical correlations. During the study period, we included 30 hemophiliac subjects with hemarthrosis who had an average age of 16.8 years. We had as much hemophiliac A as hemophiliac B; 23.3% practiced sporting activity; 10% had history of angina, involvement of the knee joint predominated at 44% (left 24%). RF positive were present in 26.7% (8/30) predominant in hemophiliacs aged from 19 to 36 (62.5%). The ASLO positive titer was found in 43.3% (13/30) predominant in children from 5 to 13 years (38.5%) with a maximum rate of 1600IU / l. There was no significant relationship between the positivity of the parameters with the presence or absence of hemarthrosis with a value of p = 0.231 and p = 0.06 respectively (p > 0.05). A large number of hemophiliac patients had a combination of clinical and biological signs in relation to diagnose rheumatic fever and rheumatoid arthritis which must be monitored as this could predict the occurrence in the short and medium term of these diseases which could be mistaken for hemarthrosisrelated to hemophilia.
VL  - 7
IS  - 4
ER  -

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Author Information

Rakotomalala Toky Randriamahazo

Laboratory of Immunology, Joseph Ravoahangy Andrianavalona University Hospital Center (JRA UHC) Antananarivo, Madagascar
Zoliarisoa Ramihajamanana

Laboratory of Hematology, Joseph Ravoahangy Andrianavalona University Hospital Center (JRA UHC) Antananarivo, Madagascar
Anjatiana Annick Raherinaivo

Laboratory of Immunology, Joseph Ravoahangy Andrianavalona University Hospital Center (JRA UHC) Antananarivo, Madagascar
Miora Rasamindrakotroka

Laboratory of Immunology, Joseph Ravoahangy Andrianavalona University Hospital Center (JRA UHC) Antananarivo, Madagascar
Davidra Rajaonatahina

Laboratory of Immunology, Joseph Ravoahangy Andrianavalona University Hospital Center (JRA UHC) Antananarivo, Madagascar
Olivat Rakoto Alson

Laboratory of Hematology, Joseph Ravoahangy Andrianavalona University Hospital Center (JRA UHC) Antananarivo, Madagascar
Andry Rasamindrakotroka

Laboratory of Immunology, Joseph Ravoahangy Andrianavalona University Hospital Center (JRA UHC) Antananarivo, Madagascar

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APA Style

Rakotomalala Toky Randriamahazo, Zoliarisoa Ramihajamanana, Anjatiana Annick Raherinaivo, Miora Rasamindrakotroka, Davidra Rajaonatahina, et al. (2020). Relationship Between Immunological Factors and Hemarthrosis in Hemophiliacs in Antananarivo Madagascar. International Journal of Immunology, 7(4), 47-50. https://doi.org/10.11648/j.iji.20190704.13

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ACS Style

Rakotomalala Toky Randriamahazo; Zoliarisoa Ramihajamanana; Anjatiana Annick Raherinaivo; Miora Rasamindrakotroka; Davidra Rajaonatahina, et al. Relationship Between Immunological Factors and Hemarthrosis in Hemophiliacs in Antananarivo Madagascar. Int. J. Immunol. 2020, 7(4), 47-50. doi: 10.11648/j.iji.20190704.13

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AMA Style

Rakotomalala Toky Randriamahazo, Zoliarisoa Ramihajamanana, Anjatiana Annick Raherinaivo, Miora Rasamindrakotroka, Davidra Rajaonatahina, et al. Relationship Between Immunological Factors and Hemarthrosis in Hemophiliacs in Antananarivo Madagascar. Int J Immunol. 2020;7(4):47-50. doi: 10.11648/j.iji.20190704.13

Copy | Download

@article{10.11648/j.iji.20190704.13,
  author = {Rakotomalala Toky Randriamahazo and Zoliarisoa Ramihajamanana and Anjatiana Annick Raherinaivo and Miora Rasamindrakotroka and Davidra Rajaonatahina and Olivat Rakoto Alson and Andry Rasamindrakotroka},
  title = {Relationship Between Immunological Factors and Hemarthrosis in Hemophiliacs in Antananarivo Madagascar},
  journal = {International Journal of Immunology},
  volume = {7},
  number = {4},
  pages = {47-50},
  doi = {10.11648/j.iji.20190704.13},
  url = {https://doi.org/10.11648/j.iji.20190704.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.iji.20190704.13},
  abstract = {Currently, there are 122 hemophiliacs in Madagascar followed at the hemophiliac treatment center of the Joseph Ravoahangy Andrianavalona University Hospital Center (JRA UHC), 55 present hemophilia B and 67 of hemophilia A. In hemophilic patients, the diagnosis of hemarthrosis is obviousin front of articular inflammation. It’s important to determinate the main risk factor as well as predisposition indicators tothe occurrence of "spontaneous" hemarthrosis in hemophiliacsfor prevention andearly careanticipation. In this prospect, the search for potentpredisposition indicator such as immunologicalfactorsis important. This is a case control study on all hemophiliacs seen at (JRA UHC) with hemarthrosis for 7 months. We have descriptively studied the qualitative and quantitative variables consisting in the determination of rheumatoid factors (RF) and the titer of antistreptolysin O (ASLO). Then we studied the statistical correlations. During the study period, we included 30 hemophiliac subjects with hemarthrosis who had an average age of 16.8 years. We had as much hemophiliac A as hemophiliac B; 23.3% practiced sporting activity; 10% had history of angina, involvement of the knee joint predominated at 44% (left 24%). RF positive were present in 26.7% (8/30) predominant in hemophiliacs aged from 19 to 36 (62.5%). The ASLO positive titer was found in 43.3% (13/30) predominant in children from 5 to 13 years (38.5%) with a maximum rate of 1600IU / l. There was no significant relationship between the positivity of the parameters with the presence or absence of hemarthrosis with a value of p = 0.231 and p = 0.06 respectively (p > 0.05). A large number of hemophiliac patients had a combination of clinical and biological signs in relation to diagnose rheumatic fever and rheumatoid arthritis which must be monitored as this could predict the occurrence in the short and medium term of these diseases which could be mistaken for hemarthrosisrelated to hemophilia.},
 year = {2020}
}

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TY  - JOUR
T1  - Relationship Between Immunological Factors and Hemarthrosis in Hemophiliacs in Antananarivo Madagascar
AU  - Rakotomalala Toky Randriamahazo
AU  - Zoliarisoa Ramihajamanana
AU  - Anjatiana Annick Raherinaivo
AU  - Miora Rasamindrakotroka
AU  - Davidra Rajaonatahina
AU  - Olivat Rakoto Alson
AU  - Andry Rasamindrakotroka
Y1  - 2020/02/13
PY  - 2020
N1  - https://doi.org/10.11648/j.iji.20190704.13
DO  - 10.11648/j.iji.20190704.13
T2  - International Journal of Immunology
JF  - International Journal of Immunology
JO  - International Journal of Immunology
SP  - 47
EP  - 50
PB  - Science Publishing Group
SN  - 2329-1753
UR  - https://doi.org/10.11648/j.iji.20190704.13
AB  - Currently, there are 122 hemophiliacs in Madagascar followed at the hemophiliac treatment center of the Joseph Ravoahangy Andrianavalona University Hospital Center (JRA UHC), 55 present hemophilia B and 67 of hemophilia A. In hemophilic patients, the diagnosis of hemarthrosis is obviousin front of articular inflammation. It’s important to determinate the main risk factor as well as predisposition indicators tothe occurrence of "spontaneous" hemarthrosis in hemophiliacsfor prevention andearly careanticipation. In this prospect, the search for potentpredisposition indicator such as immunologicalfactorsis important. This is a case control study on all hemophiliacs seen at (JRA UHC) with hemarthrosis for 7 months. We have descriptively studied the qualitative and quantitative variables consisting in the determination of rheumatoid factors (RF) and the titer of antistreptolysin O (ASLO). Then we studied the statistical correlations. During the study period, we included 30 hemophiliac subjects with hemarthrosis who had an average age of 16.8 years. We had as much hemophiliac A as hemophiliac B; 23.3% practiced sporting activity; 10% had history of angina, involvement of the knee joint predominated at 44% (left 24%). RF positive were present in 26.7% (8/30) predominant in hemophiliacs aged from 19 to 36 (62.5%). The ASLO positive titer was found in 43.3% (13/30) predominant in children from 5 to 13 years (38.5%) with a maximum rate of 1600IU / l. There was no significant relationship between the positivity of the parameters with the presence or absence of hemarthrosis with a value of p = 0.231 and p = 0.06 respectively (p > 0.05). A large number of hemophiliac patients had a combination of clinical and biological signs in relation to diagnose rheumatic fever and rheumatoid arthritis which must be monitored as this could predict the occurrence in the short and medium term of these diseases which could be mistaken for hemarthrosisrelated to hemophilia.
VL  - 7
IS  - 4
ER  -

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