@article{10.11648/j.ijbse.20221003.11,
  author = {Cianci Roberta and Masi Umberto and Buonincontro Miriam and Squillante Francesco and Bocchino Vincenzo},
  title = {COPD and COVID-19 Pneumonia: A Retrospective Single Center Analysis of Respiratory Status and Outcome},
  journal = {International Journal of Biomedical Science and Engineering},
  volume = {10},
  number = {3},
  pages = {61-68},
  doi = {10.11648/j.ijbse.20221003.11},
  url = {https://doi.org/10.11648/j.ijbse.20221003.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbse.20221003.11},
  abstract = {Acute respiratory syndrome caused by SARS-CoV-2 is associated with severe mortality in the general population. COPD patients are at risk for severe pneumonia and poor prognosis associated with COVID-19 infection. This may be due to insufficient lung reserve or the expression of the ACE-2 receptor in the small airways. We wanted to find out if COPD patients had more severe COVID-19 pneumonia and worse clinical outcomes. We did a retrospective analysis of 101 patients with COVID-19 admitted to the Pulmonology Department of Monaldi Hospital (Naples) from November 2020 to May 2021. The calculated criteria were obtained only by patients with positive real-time reverse-transcriptase-polymerase chain reaction (RT-PCR). The study included computed tomography (CT) scans with specific COVID-19 results. We used fractional inhaled oxygen (PaO2/FiO2) to assess respiratory status and Chung score on chest TC to assess the severity of COVID-19 pneumonia. We investigated comorbidities, need of ventilation (NIV/CPAP), hospitalization and patients’ outcome. We used descriptive statistics, Chi square test and independent sample test to analyze our population. Out of 101 patients, 10,89% of them had COPD in anamnesis or had enphysema on chest TC. In the patients without COPD the mean P/F ratio was 167,9 (SD: 93.854). Their mean Chung score was 12,178 (SD: 3,505). They had an average of 20.111 (SD: 11.037) hospitalization days. 40% of them needed non-invasive ventilation (including CPAP) and 28,9% of them died. In patients with COPD the mean P/F ratio was 124,273 (SD: 61,254). Their mean Chung score was 11,727 (SD: 4,149). They had a mean hospitalization days of 22,273 (SD: 11,714). 63,636% of them needed non-invasive ventilation (including CPAP) and 72,727% of them died. In COPD patients we observed a higher prevalence of obesity, a higher number of deaths and a higher LDH value. In particular in obese patients that needed noninvasive ventilation we found a longer hospitalization and a higher LDH value. Although the two groups studied had the same severity of respiratory status and pneumonia, we found a worse outcome in patients with COPD.},
 year = {2022}
}

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TY  - JOUR
T1  - COPD and COVID-19 Pneumonia: A Retrospective Single Center Analysis of Respiratory Status and Outcome
AU  - Cianci Roberta
AU  - Masi Umberto
AU  - Buonincontro Miriam
AU  - Squillante Francesco
AU  - Bocchino Vincenzo
Y1  - 2022/07/20
PY  - 2022
N1  - https://doi.org/10.11648/j.ijbse.20221003.11
DO  - 10.11648/j.ijbse.20221003.11
T2  - International Journal of Biomedical Science and Engineering
JF  - International Journal of Biomedical Science and Engineering
JO  - International Journal of Biomedical Science and Engineering
SP  - 61
EP  - 68
PB  - Science Publishing Group
SN  - 2376-7235
UR  - https://doi.org/10.11648/j.ijbse.20221003.11
AB  - Acute respiratory syndrome caused by SARS-CoV-2 is associated with severe mortality in the general population. COPD patients are at risk for severe pneumonia and poor prognosis associated with COVID-19 infection. This may be due to insufficient lung reserve or the expression of the ACE-2 receptor in the small airways. We wanted to find out if COPD patients had more severe COVID-19 pneumonia and worse clinical outcomes. We did a retrospective analysis of 101 patients with COVID-19 admitted to the Pulmonology Department of Monaldi Hospital (Naples) from November 2020 to May 2021. The calculated criteria were obtained only by patients with positive real-time reverse-transcriptase-polymerase chain reaction (RT-PCR). The study included computed tomography (CT) scans with specific COVID-19 results. We used fractional inhaled oxygen (PaO2/FiO2) to assess respiratory status and Chung score on chest TC to assess the severity of COVID-19 pneumonia. We investigated comorbidities, need of ventilation (NIV/CPAP), hospitalization and patients’ outcome. We used descriptive statistics, Chi square test and independent sample test to analyze our population. Out of 101 patients, 10,89% of them had COPD in anamnesis or had enphysema on chest TC. In the patients without COPD the mean P/F ratio was 167,9 (SD: 93.854). Their mean Chung score was 12,178 (SD: 3,505). They had an average of 20.111 (SD: 11.037) hospitalization days. 40% of them needed non-invasive ventilation (including CPAP) and 28,9% of them died. In patients with COPD the mean P/F ratio was 124,273 (SD: 61,254). Their mean Chung score was 11,727 (SD: 4,149). They had a mean hospitalization days of 22,273 (SD: 11,714). 63,636% of them needed non-invasive ventilation (including CPAP) and 72,727% of them died. In COPD patients we observed a higher prevalence of obesity, a higher number of deaths and a higher LDH value. In particular in obese patients that needed noninvasive ventilation we found a longer hospitalization and a higher LDH value. Although the two groups studied had the same severity of respiratory status and pneumonia, we found a worse outcome in patients with COPD.
VL  - 10
IS  - 3
ER  - 

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