Magnitude and Associated Factors of Postoperative Myalgia Among Patients Who Undergo Surgery in Wolaita Sodo Teaching and Referral Hospital, Southern Ethiopia

Bulcha Guye Adema; Mohammed Sulieman Obsa; Mihret Zerifu; Dirba Bekele; Desta Yacob

doi:doi:10.11648/j.ijbse.20200801.11

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Magnitude and Associated Factors of Postoperative Myalgia Among Patients Who Undergo Surgery in Wolaita Sodo Teaching and Referral Hospital, Southern Ethiopia

Bulcha Guye Adema, Mohammed Sulieman Obsa, Mihret Zerifu, Dirba Bekele, Desta Yacob

Published in International Journal of Biomedical Science and Engineering (Volume 8, Issue 1)

Received: 29 February 2020 Accepted: 18 March 2020 Published: 14 April 2020

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Abstract

Introduction: Even though, Suxamethonium is the only short acting and accepted standard for rapid sequence intubation, it is associated with a high risk of complications. Some complications are minor, but others are potentially life threatening. Post-operative myalgia and fasciculation are the two most common and distressing side effects of succinylcholine administration. Objective: To assess the magnitude and associated factors of postoperative myalgia following Suxamethonium administration among patients undergoing surgery in Wolaita Sodo Teaching and Referral Hospital from April 30- May 30, 2019. Methods: Facility based cross sectional survey will be conducted by using convenient sampling technique. Training was given for data collectors and supervisors. Regular supervision and follow up were made. Data was entered in to Epi info version 7 software and transported to SPSS version 20 for analysis. Odd ratio and 95% confidence interval was computed. Bivariate and Multivariate analysis used to identify factors associated with hypotension. Results: The magnitude of postoperative myalgia is high at 12 hour in which 18 (36%) develop mild pain where us the magnitude is lower at 24 hour, 14 (28%). More than half 27 (54%) have no postoperative myalgia at 12 hour. Patients who did not take pretreatment agent before administration of Suxamethonium were 15 times more likely to develop post-operative myalgia at 12 hour when compared to patients who take pretreatment agent before Suxamethonium administration (AOR=15.12, 95%CI: 1.39, 163.53) Conclusion: The magnitude of Suxamethonium induced myalgia is higher at 12 hour than 24 hour post operative and lack of per-treatment agent and repeated dose of Suxamethonium are main risk factors of postoperative myalgia.

Published in	International Journal of Biomedical Science and Engineering (Volume 8, Issue 1)
DOI	10.11648/j.ijbse.20200801.11
Page(s)	1-5
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Suxamethonium, Postoperative Myalgia, Magnitude

References

[1]	Oxorn DC, Whatley GS, Knox JWD, Hooper J. The importance of activity and pretreatment in the prevention of sexuamethonium myalgias. Br J Anaesth [Internet]. 1992; 69 (2): 200–1. Available from: http://dx.doi.org/10.1093/bja/69.2.200.
[2]	Miller RD, Ward TA, Shiboski SC, Cohen NH. A comparison of three methods of hemoglobin monitoring in patients undergoing spine surgery. Anesth Analg. 2011; 112 (4): 858–63.
[3]	Shafy SZ, Hakim M, Krishna SG, Tobias JD. Succinylcholine-Induced Postoperative Myalgia: Etiology and Prevention. J Med Cases. 2018; 9 (8): 264–6.
[4]	Khan MA, Siddiqi KJ, Anjum KM, Hamza A. A randomized controlled study on prevention of succinylcholine induced fasciculation and myalgia by pretreatment with pregabalin in patients undergoing laparoscopic cholecystectomy. Anaesthesia, Pain Intensive Care. 2017; 21 (4): 447–52.
[5]	Schreiber JU, Mencke T, Biedler A, Fürst O, Kleinschmidt S, Buchinger H, et al. Postoperative myalgia after succinylcholine: No evidence for an inflammatory origin. Anesth Analg. 2003; 96 (6): 1640–4.
[6]	Ruddell JS. Suxamethonium Chloride and Muscle Pain. Br Med J. 1957; 2 (5043): 527.
[7]	Wong SF, Chung F. Succinylcholine-associated postoperative myalgia. Anaesthesia. 2000; 55 (2): 144–52.
[8]	Maddineni VR, Mirakhur RK, Building WM. Volume 48, page 626-628 Myalgia and biochemical changes following suxarnethonium after induction of anaesthesia with thiopentone or propofol V. R. Maddineni, MD, FFARCSI, R. K. Mirakhur, MD, FRCA, A. 1993; 48: 626–8.
[9]	Amornyotin S. Can lidocaine reduce suxamethonium induced postoperative myalgia? Vol. 85, Journal of Medical Association of Thailand. 2002. p. S 969-974.
[10]	Fatemeh H, Mojgan R. Comparison of atracurium and “mini-dose” succinylcholine for preventing succinylcholine-induced muscle fasciculations: A randomized, double-blind, placebo-controlled study. Acta Anaesthesiol Taiwanica [Internet]. 2010; 48 (1): 28–32. Available from: http://dx.doi.org/10.1016/S1875-4597(10)60006-9.
[11]	Srivastava VK, Agrawal S, Nimbhorkar VK, Mishra A, Sharma S, Panda PK. Prophylactic use of pregabalin for prevention of succinylcholine-induced fasciculation and myalgia: a randomized, double-blinded, placebo-controlled study. Brazilian J Anesthesiol (English Ed [Internet]. 2016; 66 (2): 165–70. Available from: http://dx.doi.org/10.1016/j.bjane.2014.08.004.
[12]	Parmar S, Vyas A, Sheikh A. Usefulness of propofol to prevent succinylcholine induced fasciculations and myalgia, a comparison with thiopentone sodium as an induction agent. Int J Med Sci Public Heal. 2013; 2 (2): 339.
[13]	Abraham V, Kumar AR, Afzal L. Evaluation of Post Succinylcholine Myalgia and Intubation Conditions with Rocuronium Pretreatment : A Comparison with Vecuronium. Indian J Anaesth. 2008; 52 (5): 551–5.
[14]	Nasseri K, Arvien S. Effects of low-dose ketamine on succinylcholine-induced postoperative myalgia in outpatient surgeries: A randomized, double-blind study. J Pain Res. 2016; 9: 503–8.
[15]	Newnam PTF, Loudon JM. Muscle pain following administration of suxamethonium: The aetiological role of muscular fitness. Br J Anaesth. 1966; 38 (7): 533–40.
[16]	Chloride S, Pains M. Suxamethonium (succinylcholine) chloride. 1954; 1.

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Bulcha Guye Adema, Mohammed Sulieman Obsa, Mihret Zerifu, Dirba Bekele, Desta Yacob. (2020). Magnitude and Associated Factors of Postoperative Myalgia Among Patients Who Undergo Surgery in Wolaita Sodo Teaching and Referral Hospital, Southern Ethiopia. International Journal of Biomedical Science and Engineering, 8(1), 1-5. https://doi.org/10.11648/j.ijbse.20200801.11

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Bulcha Guye Adema; Mohammed Sulieman Obsa; Mihret Zerifu; Dirba Bekele; Desta Yacob. Magnitude and Associated Factors of Postoperative Myalgia Among Patients Who Undergo Surgery in Wolaita Sodo Teaching and Referral Hospital, Southern Ethiopia. Int. J. Biomed. Sci. Eng. 2020, 8(1), 1-5. doi: 10.11648/j.ijbse.20200801.11

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AMA Style

Bulcha Guye Adema, Mohammed Sulieman Obsa, Mihret Zerifu, Dirba Bekele, Desta Yacob. Magnitude and Associated Factors of Postoperative Myalgia Among Patients Who Undergo Surgery in Wolaita Sodo Teaching and Referral Hospital, Southern Ethiopia. Int J Biomed Sci Eng. 2020;8(1):1-5. doi: 10.11648/j.ijbse.20200801.11

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@article{10.11648/j.ijbse.20200801.11,
  author = {Bulcha Guye Adema and Mohammed Sulieman Obsa and Mihret Zerifu and Dirba Bekele and Desta Yacob},
  title = {Magnitude and Associated Factors of Postoperative Myalgia Among Patients Who Undergo Surgery in Wolaita Sodo Teaching and Referral Hospital, Southern Ethiopia},
  journal = {International Journal of Biomedical Science and Engineering},
  volume = {8},
  number = {1},
  pages = {1-5},
  doi = {10.11648/j.ijbse.20200801.11},
  url = {https://doi.org/10.11648/j.ijbse.20200801.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbse.20200801.11},
  abstract = {Introduction: Even though, Suxamethonium is the only short acting and accepted standard for rapid sequence intubation, it is associated with a high risk of complications. Some complications are minor, but others are potentially life threatening. Post-operative myalgia and fasciculation are the two most common and distressing side effects of succinylcholine administration. Objective: To assess the magnitude and associated factors of postoperative myalgia following Suxamethonium administration among patients undergoing surgery in Wolaita Sodo Teaching and Referral Hospital from April 30- May 30, 2019. Methods: Facility based cross sectional survey will be conducted by using convenient sampling technique. Training was given for data collectors and supervisors. Regular supervision and follow up were made. Data was entered in to Epi info version 7 software and transported to SPSS version 20 for analysis. Odd ratio and 95% confidence interval was computed. Bivariate and Multivariate analysis used to identify factors associated with hypotension. Results: The magnitude of postoperative myalgia is high at 12 hour in which 18 (36%) develop mild pain where us the magnitude is lower at 24 hour, 14 (28%). More than half 27 (54%) have no postoperative myalgia at 12 hour. Patients who did not take pretreatment agent before administration of Suxamethonium were 15 times more likely to develop post-operative myalgia at 12 hour when compared to patients who take pretreatment agent before Suxamethonium administration (AOR=15.12, 95%CI: 1.39, 163.53) Conclusion: The magnitude of Suxamethonium induced myalgia is higher at 12 hour than 24 hour post operative and lack of per-treatment agent and repeated dose of Suxamethonium are main risk factors of postoperative myalgia.},
 year = {2020}
}

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TY - JOUR
T1 - Magnitude and Associated Factors of Postoperative Myalgia Among Patients Who Undergo Surgery in Wolaita Sodo Teaching and Referral Hospital, Southern Ethiopia
AU - Bulcha Guye Adema
AU - Mohammed Sulieman Obsa
AU - Mihret Zerifu
AU - Dirba Bekele
AU - Desta Yacob
Y1 - 2020/04/14
PY - 2020
N1 - https://doi.org/10.11648/j.ijbse.20200801.11
DO - 10.11648/j.ijbse.20200801.11
T2 - International Journal of Biomedical Science and Engineering
JF - International Journal of Biomedical Science and Engineering
JO - International Journal of Biomedical Science and Engineering
SP - 1
EP - 5
PB - Science Publishing Group
SN - 2376-7235
UR - https://doi.org/10.11648/j.ijbse.20200801.11
AB - Introduction: Even though, Suxamethonium is the only short acting and accepted standard for rapid sequence intubation, it is associated with a high risk of complications. Some complications are minor, but others are potentially life threatening. Post-operative myalgia and fasciculation are the two most common and distressing side effects of succinylcholine administration. Objective: To assess the magnitude and associated factors of postoperative myalgia following Suxamethonium administration among patients undergoing surgery in Wolaita Sodo Teaching and Referral Hospital from April 30- May 30, 2019. Methods: Facility based cross sectional survey will be conducted by using convenient sampling technique. Training was given for data collectors and supervisors. Regular supervision and follow up were made. Data was entered in to Epi info version 7 software and transported to SPSS version 20 for analysis. Odd ratio and 95% confidence interval was computed. Bivariate and Multivariate analysis used to identify factors associated with hypotension. Results: The magnitude of postoperative myalgia is high at 12 hour in which 18 (36%) develop mild pain where us the magnitude is lower at 24 hour, 14 (28%). More than half 27 (54%) have no postoperative myalgia at 12 hour. Patients who did not take pretreatment agent before administration of Suxamethonium were 15 times more likely to develop post-operative myalgia at 12 hour when compared to patients who take pretreatment agent before Suxamethonium administration (AOR=15.12, 95%CI: 1.39, 163.53) Conclusion: The magnitude of Suxamethonium induced myalgia is higher at 12 hour than 24 hour post operative and lack of per-treatment agent and repeated dose of Suxamethonium are main risk factors of postoperative myalgia.
VL - 8
IS - 1
ER -

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Author Information

Bulcha Guye Adema

Department Pediatrics and Neonatal Nursing, College of Health Science, Woliata Sodo University, Woliata, Ethiopia
Mohammed Sulieman Obsa

Department Anesthesia, College of Health Science, Woliata Sodo University, Woliata, Ethiopia
Mihret Zerifu

Department Anesthesia, College of Health Science, Woliata Sodo University, Woliata, Ethiopia
Dirba Bekele

Department Anesthesia, College of Health Science, Woliata Sodo University, Woliata, Ethiopia
Desta Yacob

Department Anesthesia, College of Health Science, Woliata Sodo University, Woliata, Ethiopia

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Bulcha Guye Adema, Mohammed Sulieman Obsa, Mihret Zerifu, Dirba Bekele, Desta Yacob. (2020). Magnitude and Associated Factors of Postoperative Myalgia Among Patients Who Undergo Surgery in Wolaita Sodo Teaching and Referral Hospital, Southern Ethiopia. International Journal of Biomedical Science and Engineering, 8(1), 1-5. https://doi.org/10.11648/j.ijbse.20200801.11

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ACS Style

Bulcha Guye Adema; Mohammed Sulieman Obsa; Mihret Zerifu; Dirba Bekele; Desta Yacob. Magnitude and Associated Factors of Postoperative Myalgia Among Patients Who Undergo Surgery in Wolaita Sodo Teaching and Referral Hospital, Southern Ethiopia. Int. J. Biomed. Sci. Eng. 2020, 8(1), 1-5. doi: 10.11648/j.ijbse.20200801.11

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AMA Style

Bulcha Guye Adema, Mohammed Sulieman Obsa, Mihret Zerifu, Dirba Bekele, Desta Yacob. Magnitude and Associated Factors of Postoperative Myalgia Among Patients Who Undergo Surgery in Wolaita Sodo Teaching and Referral Hospital, Southern Ethiopia. Int J Biomed Sci Eng. 2020;8(1):1-5. doi: 10.11648/j.ijbse.20200801.11

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@article{10.11648/j.ijbse.20200801.11,
  author = {Bulcha Guye Adema and Mohammed Sulieman Obsa and Mihret Zerifu and Dirba Bekele and Desta Yacob},
  title = {Magnitude and Associated Factors of Postoperative Myalgia Among Patients Who Undergo Surgery in Wolaita Sodo Teaching and Referral Hospital, Southern Ethiopia},
  journal = {International Journal of Biomedical Science and Engineering},
  volume = {8},
  number = {1},
  pages = {1-5},
  doi = {10.11648/j.ijbse.20200801.11},
  url = {https://doi.org/10.11648/j.ijbse.20200801.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbse.20200801.11},
  abstract = {Introduction: Even though, Suxamethonium is the only short acting and accepted standard for rapid sequence intubation, it is associated with a high risk of complications. Some complications are minor, but others are potentially life threatening. Post-operative myalgia and fasciculation are the two most common and distressing side effects of succinylcholine administration. Objective: To assess the magnitude and associated factors of postoperative myalgia following Suxamethonium administration among patients undergoing surgery in Wolaita Sodo Teaching and Referral Hospital from April 30- May 30, 2019. Methods: Facility based cross sectional survey will be conducted by using convenient sampling technique. Training was given for data collectors and supervisors. Regular supervision and follow up were made. Data was entered in to Epi info version 7 software and transported to SPSS version 20 for analysis. Odd ratio and 95% confidence interval was computed. Bivariate and Multivariate analysis used to identify factors associated with hypotension. Results: The magnitude of postoperative myalgia is high at 12 hour in which 18 (36%) develop mild pain where us the magnitude is lower at 24 hour, 14 (28%). More than half 27 (54%) have no postoperative myalgia at 12 hour. Patients who did not take pretreatment agent before administration of Suxamethonium were 15 times more likely to develop post-operative myalgia at 12 hour when compared to patients who take pretreatment agent before Suxamethonium administration (AOR=15.12, 95%CI: 1.39, 163.53) Conclusion: The magnitude of Suxamethonium induced myalgia is higher at 12 hour than 24 hour post operative and lack of per-treatment agent and repeated dose of Suxamethonium are main risk factors of postoperative myalgia.},
 year = {2020}
}

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