Association between Tumor Stage and Grade and Mean Platelet Volume in Patients with Renal Cell Carcinoma

Ibrahim Keles; Cavit Ceylan; Erdogan Aglamis; Hasan Salih Saglam; Mustafa Karalar; Soner Coban; Sait Bicer; Oztug Adsan; Mehmet Ozgur Yucel

doi:doi:10.11648/j.cmr.20140302.16

Association between Tumor Stage and Grade and Mean Platelet Volume in Patients with Renal Cell Carcinoma

Ibrahim Keles, Cavit Ceylan, Erdogan Aglamis, Hasan Salih Saglam, Mustafa Karalar, Soner Coban, Sait Bicer, Oztug Adsan, Mehmet Ozgur Yucel

Published in Clinical Medicine Research (Volume 3, Issue 2)

Received: 3 March 2014 Published: 30 March 2014

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Abstract

Purpose: To research association between Mean Platelet Volume (MPV) and tumor stage and grade in non-metastatic renal cell carcinomas in circumstances of hypoxia, thromboembolism, and ischemia, based on MPV increase. Material and methods: Data of 104 non-metastatic patients, in whom nephrectomy was done and whose pathology resulted in renal cell carcinoma, have been evaluated retrospectively. The patients were clinically classified as T1a, T1b, T2a, T2b according to TNM stage and as Fuhrman Grade 1, 2, 3, 4 according to pathology results. Preoperative mean platelet number and MPV values of the patients were compared with their tumor stage and grade. Results: Sixteen (15%) were in T1a, 41 (39%) were in T1b, 39 (38%) were in T2a, and 8 (7%) of the patients were in T2b clinical stage. According to pathology results, 21 (20%) were assessed as Fuhrman grade I, 59 (57%) were grade II, 22 (21%) were grade III, and 2 (2%) of the patients were grade IV. Mean MPV values were 8.50±1.39, 8.51±1.25, 8.65±1.12, and 8.95±0.07 in Grade I, II, III, IV, respectively. A positive correlation was present between mean MPV and grade (r= 0.052, p=0.599). As long as grade increases, mean MPV values were observed to increase. However, no statistically difference was determined between tumor grade and mean MPV and platelet (p values: 0.935 and 0.963, respectively). No statistically significant difference was detected between tumor stage and mean MPV and platelet (p values: 0.996 and 0.397, respectively). Conclusion: A positive correlation was observed to be between mean MPV values and tumor grade. However, no statistically significant difference was determined. It can be supported with the larger series that MPV for renal tumors, that is rapidly and expansively growing tumor, can be an effective biochemical indicator in early diagnosis, staging, and evaluation of response to treatment.

Published in	Clinical Medicine Research (Volume 3, Issue 2)
DOI	10.11648/j.cmr.20140302.16
Page(s)	36-39
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2014. Published by Science Publishing Group

Keywords

Renal Cell Carcinoma, Stage, Grade, Mean Platelet Volume

References

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APA Style

Ibrahim Keles, Cavit Ceylan, Erdogan Aglamis, Hasan Salih Saglam, Mustafa Karalar, et al. (2014). Association between Tumor Stage and Grade and Mean Platelet Volume in Patients with Renal Cell Carcinoma. Clinical Medicine Research, 3(2), 36-39. https://doi.org/10.11648/j.cmr.20140302.16

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ACS Style

Ibrahim Keles; Cavit Ceylan; Erdogan Aglamis; Hasan Salih Saglam; Mustafa Karalar, et al. Association between Tumor Stage and Grade and Mean Platelet Volume in Patients with Renal Cell Carcinoma. Clin. Med. Res. 2014, 3(2), 36-39. doi: 10.11648/j.cmr.20140302.16

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AMA Style

Ibrahim Keles, Cavit Ceylan, Erdogan Aglamis, Hasan Salih Saglam, Mustafa Karalar, et al. Association between Tumor Stage and Grade and Mean Platelet Volume in Patients with Renal Cell Carcinoma. Clin Med Res. 2014;3(2):36-39. doi: 10.11648/j.cmr.20140302.16

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@article{10.11648/j.cmr.20140302.16,
  author = {Ibrahim Keles and Cavit Ceylan and Erdogan Aglamis and Hasan Salih Saglam and Mustafa Karalar and Soner Coban and Sait Bicer and Oztug Adsan and Mehmet Ozgur Yucel},
  title = {Association between Tumor Stage and Grade and Mean Platelet Volume in Patients with Renal Cell Carcinoma},
  journal = {Clinical Medicine Research},
  volume = {3},
  number = {2},
  pages = {36-39},
  doi = {10.11648/j.cmr.20140302.16},
  url = {https://doi.org/10.11648/j.cmr.20140302.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20140302.16},
  abstract = {Purpose: To research association between Mean Platelet Volume (MPV) and tumor stage and grade in non-metastatic renal cell carcinomas in circumstances of hypoxia, thromboembolism, and ischemia, based on MPV increase. Material and methods: Data of 104 non-metastatic patients, in whom nephrectomy was done and whose pathology resulted in renal cell carcinoma, have been evaluated retrospectively. The patients were clinically classified as T1a, T1b, T2a, T2b according to TNM stage and as Fuhrman Grade 1, 2, 3, 4 according to pathology results. Preoperative mean platelet number and MPV values of the patients were compared with their tumor stage and grade. Results: Sixteen (15%) were in T1a, 41 (39%) were in T1b, 39 (38%) were in T2a, and 8 (7%) of the patients were in T2b clinical stage. According to pathology results, 21 (20%) were assessed as Fuhrman grade I, 59 (57%) were grade II, 22 (21%) were grade III, and 2 (2%) of the patients were grade IV. Mean MPV values were 8.50±1.39, 8.51±1.25, 8.65±1.12, and 8.95±0.07 in Grade I, II, III, IV, respectively. A positive correlation was present between mean MPV and grade (r= 0.052, p=0.599). As long as grade increases, mean MPV values were observed to increase. However, no statistically difference was determined between tumor grade and mean MPV and platelet (p values: 0.935 and 0.963, respectively). No statistically significant difference was detected between tumor stage and mean MPV and platelet (p values: 0.996 and 0.397, respectively). Conclusion: A positive correlation was observed to be between mean MPV values and tumor grade. However, no statistically significant difference was determined. It can be supported with the larger series that MPV for renal tumors, that is rapidly and expansively growing tumor, can be an effective biochemical indicator in early diagnosis, staging, and evaluation of response to treatment.},
 year = {2014}
}

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TY - JOUR
T1 - Association between Tumor Stage and Grade and Mean Platelet Volume in Patients with Renal Cell Carcinoma
AU - Ibrahim Keles
AU - Cavit Ceylan
AU - Erdogan Aglamis
AU - Hasan Salih Saglam
AU - Mustafa Karalar
AU - Soner Coban
AU - Sait Bicer
AU - Oztug Adsan
AU - Mehmet Ozgur Yucel
Y1 - 2014/03/30
PY - 2014
N1 - https://doi.org/10.11648/j.cmr.20140302.16
DO - 10.11648/j.cmr.20140302.16
T2 - Clinical Medicine Research
JF - Clinical Medicine Research
JO - Clinical Medicine Research
SP - 36
EP - 39
PB - Science Publishing Group
SN - 2326-9057
UR - https://doi.org/10.11648/j.cmr.20140302.16
AB - Purpose: To research association between Mean Platelet Volume (MPV) and tumor stage and grade in non-metastatic renal cell carcinomas in circumstances of hypoxia, thromboembolism, and ischemia, based on MPV increase. Material and methods: Data of 104 non-metastatic patients, in whom nephrectomy was done and whose pathology resulted in renal cell carcinoma, have been evaluated retrospectively. The patients were clinically classified as T1a, T1b, T2a, T2b according to TNM stage and as Fuhrman Grade 1, 2, 3, 4 according to pathology results. Preoperative mean platelet number and MPV values of the patients were compared with their tumor stage and grade. Results: Sixteen (15%) were in T1a, 41 (39%) were in T1b, 39 (38%) were in T2a, and 8 (7%) of the patients were in T2b clinical stage. According to pathology results, 21 (20%) were assessed as Fuhrman grade I, 59 (57%) were grade II, 22 (21%) were grade III, and 2 (2%) of the patients were grade IV. Mean MPV values were 8.50±1.39, 8.51±1.25, 8.65±1.12, and 8.95±0.07 in Grade I, II, III, IV, respectively. A positive correlation was present between mean MPV and grade (r= 0.052, p=0.599). As long as grade increases, mean MPV values were observed to increase. However, no statistically difference was determined between tumor grade and mean MPV and platelet (p values: 0.935 and 0.963, respectively). No statistically significant difference was detected between tumor stage and mean MPV and platelet (p values: 0.996 and 0.397, respectively). Conclusion: A positive correlation was observed to be between mean MPV values and tumor grade. However, no statistically significant difference was determined. It can be supported with the larger series that MPV for renal tumors, that is rapidly and expansively growing tumor, can be an effective biochemical indicator in early diagnosis, staging, and evaluation of response to treatment.
VL - 3
IS - 2
ER -

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Author Information

Ibrahim Keles

Department of urology, Kocatepe University, Medical Faculty, Afyon, Turkey
Cavit Ceylan

Department of urology, Turkey Yuksek Ihtisas Education and Research Hospital, Ankara, Turkey
Erdogan Aglamis

Department of urology, Elazig Education and Research Hospital, Elazig, Turkey
Hasan Salih Saglam

Department of urology, Sakarya University, Medical Faculty, Sakarya, Turkey
Mustafa Karalar

Department of urology, Kocatepe University, Medical Faculty, Afyon, Turkey
Soner Coban

Department of urology, Sevket Yilmaz Education and Research Hospital, Bursa, Turkey
Sait Bicer

Department of urology, Turkey Yuksek Ihtisas Education and Research Hospital, Ankara, Turkey
Oztug Adsan

Department of urology, Sakarya University, Medical Faculty, Sakarya, Turkey
Mehmet Ozgur Yucel

Department of urology, Adiyaman University, Education and Research Hospital, Adiyaman, Turkey

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APA Style

Ibrahim Keles, Cavit Ceylan, Erdogan Aglamis, Hasan Salih Saglam, Mustafa Karalar, et al. (2014). Association between Tumor Stage and Grade and Mean Platelet Volume in Patients with Renal Cell Carcinoma. Clinical Medicine Research, 3(2), 36-39. https://doi.org/10.11648/j.cmr.20140302.16

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ACS Style

Ibrahim Keles; Cavit Ceylan; Erdogan Aglamis; Hasan Salih Saglam; Mustafa Karalar, et al. Association between Tumor Stage and Grade and Mean Platelet Volume in Patients with Renal Cell Carcinoma. Clin. Med. Res. 2014, 3(2), 36-39. doi: 10.11648/j.cmr.20140302.16

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AMA Style

Ibrahim Keles, Cavit Ceylan, Erdogan Aglamis, Hasan Salih Saglam, Mustafa Karalar, et al. Association between Tumor Stage and Grade and Mean Platelet Volume in Patients with Renal Cell Carcinoma. Clin Med Res. 2014;3(2):36-39. doi: 10.11648/j.cmr.20140302.16

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@article{10.11648/j.cmr.20140302.16,
  author = {Ibrahim Keles and Cavit Ceylan and Erdogan Aglamis and Hasan Salih Saglam and Mustafa Karalar and Soner Coban and Sait Bicer and Oztug Adsan and Mehmet Ozgur Yucel},
  title = {Association between Tumor Stage and Grade and Mean Platelet Volume in Patients with Renal Cell Carcinoma},
  journal = {Clinical Medicine Research},
  volume = {3},
  number = {2},
  pages = {36-39},
  doi = {10.11648/j.cmr.20140302.16},
  url = {https://doi.org/10.11648/j.cmr.20140302.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20140302.16},
  abstract = {Purpose: To research association between Mean Platelet Volume (MPV) and tumor stage and grade in non-metastatic renal cell carcinomas in circumstances of hypoxia, thromboembolism, and ischemia, based on MPV increase. Material and methods: Data of 104 non-metastatic patients, in whom nephrectomy was done and whose pathology resulted in renal cell carcinoma, have been evaluated retrospectively. The patients were clinically classified as T1a, T1b, T2a, T2b according to TNM stage and as Fuhrman Grade 1, 2, 3, 4 according to pathology results. Preoperative mean platelet number and MPV values of the patients were compared with their tumor stage and grade. Results: Sixteen (15%) were in T1a, 41 (39%) were in T1b, 39 (38%) were in T2a, and 8 (7%) of the patients were in T2b clinical stage. According to pathology results, 21 (20%) were assessed as Fuhrman grade I, 59 (57%) were grade II, 22 (21%) were grade III, and 2 (2%) of the patients were grade IV. Mean MPV values were 8.50±1.39, 8.51±1.25, 8.65±1.12, and 8.95±0.07 in Grade I, II, III, IV, respectively. A positive correlation was present between mean MPV and grade (r= 0.052, p=0.599). As long as grade increases, mean MPV values were observed to increase. However, no statistically difference was determined between tumor grade and mean MPV and platelet (p values: 0.935 and 0.963, respectively). No statistically significant difference was detected between tumor stage and mean MPV and platelet (p values: 0.996 and 0.397, respectively). Conclusion: A positive correlation was observed to be between mean MPV values and tumor grade. However, no statistically significant difference was determined. It can be supported with the larger series that MPV for renal tumors, that is rapidly and expansively growing tumor, can be an effective biochemical indicator in early diagnosis, staging, and evaluation of response to treatment.},
 year = {2014}
}

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