Ethological Problems and Learning Disability Due to Aluminum Toxicity in Rats

Amira A. Goma; Usama E. Mahrous

doi:doi:10.11648/j.avs.20130102.11

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Ethological Problems and Learning Disability Due to Aluminum Toxicity in Rats

Amira A. Goma, Usama E. Mahrous

Published in Animal and Veterinary Sciences (Volume 1, Issue 2)

Published: 10 March 2013

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Abstract

A total of 35 Sprague-Dawley adult rats were used to investigate the effect of aluminum toxicity on behavioral patterns of adult female rats and learning ability of offspring. Rats were allotted into 4 groups, group one received 2g/l anhydrous aluminum chloride (n=10), group two received 3g/l anhydrous aluminum chloride (n=10), group thr.ee received 3.5g/l anhydrous aluminum chloride in drinking water (n=10) and control group did not receive anhydrous aluminum chloride (n=5) from 8th day of pregnancy till weaning of pups. The obtained results showed that feeding time increased significantly in 2g/l and 3.5g/l anhydrous aluminum chloride groups than control one, while, litter licking frequency and nursing time increased significantly in 2g/l anhydrous aluminum chloride than other groups. On contrary lying time decreased significantly in rats treated with 2g/l anhydrous aluminum chloride than other groups, licking and scratching decreased in 3g/l and 3.5g/l anhydrous aluminum chloride groups. In considering, the time spent in closed arms by offspring, pups spent significantly much time than control group, while, time spent in open arms of elevated plus maze decreased significantly in all treated groups than control group. On the other hand, number of entries in open arms significantly decreased in treated groups than control one.

Published in	Animal and Veterinary Sciences (Volume 1, Issue 2)
DOI	10.11648/j.avs.20130102.11
Page(s)	12-17
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2013. Published by Science Publishing Group

Keywords

Aluminum Toxicity, Rats, Learning Ability, Behavior

References

[1]	Abdel-Aal, R.A.; Assi, A.A. and Kostandy, B.B. Rivastigmine reverses aluminum induced behavioral changes in rats. European Journal Behavioral Pharmacology. 659:169-176 (2011).
[2]	Bernuzzi, V.; Desor, D. and Lehr., P.R. Effects of prenatal aluminum exposure on neuromotor maturation in the rat. Neurobehav. Toxicol. Teratol. 8:115-119 (1986).
[3]	Bimonte-Nelson, H.A.; Hunter, C.L.; Nelson, M.E. and Granholm, A.C. Frontal cortex BDNF levels correlate with working memory in an animal model of Down syndrome. Behav.Brain.Res.139:47-57 (2003).
[4]	Bonnie, L. and Carson, S. Aluminum compound. A review of toxicological literature. Abridged final report, Scott, M (2000).
[5]	Bridges, R.S. and Ronsheim, P.M. Prolactin regulation of maternal behavior in rats: Bromocriptine treatment delays and prolactin promotes the rapid onset of behavior. Endocrinology. 126:837-848 (1990).
[6]	Colomina, M.T.; Roig, J.L.; Sanchez, D.J. and Domingo, J.L. Influence of age on aluminum induced neurobehavioral effects and morphological changes in rat brain. Neurotoxicology. 23:775-781 (2002).
[7]	Colomina, M.T.; Rogi. J.L; Torrente, M.; Vicens, P.and Do-mingo, J.L. Concurrent exposure to aluminum and stress during pregnancy in rats: Effects on postnatal development and behavior of the offspring. Neurotoxicol.Teratol.27: 565-574 (2005).
[8]	Delville, Y. Exposure to lead during development alters aggressive behavior in golden hamsters. Neurotoxicol. Teratol. 21:445-449 (1999).
[9]	Domingo, J.L.; Gomez, M. and Colomina, M.T. Risks of aluminum exposure during pregnancy. Contributions to Science. 1: 479-487 (2000).
[10]	Fatma, H.S. Influence of some environmental stressors on response and behavior of laboratory rats. MVSC, Thesis, Cairo university, beni-suef branch, faculty of veterinary medicine (2005).
[11]	Ferreira, A.; Pereira, M.; Agrati, D.; Uriarte, N. and Fer-mandez-Guasti, A. Role of maternal behavior on aggression, fear and anxiety. Physiology and Behavior. 77:197-204 (2002).
[12]	Friend, T.H. Symposium: Response of animals to stress. J. Dairy. Sci. 74:292-303 (1991).
[13]	Gromysz-Kalkowska, K.; Kanoniuk, D.; Szubartowska, E. and Unkiewicz-Winiarczyk, A. Influence of drinking wa-ter-administered aluminum on morphology and respiratory function of blood in rats. Polish Journal of Environmental Studies. 13: 515-519 (2004).
[14]	Harkness, J.E. and Wagner, J.E. Biology and Husbandry. In: the biology and medicine of rabbits and rodents. (2nd ed), Lea and Feiger: 36-51 (1983).
[15]	Kaoud, H.A.; Kamel. M.M. and Abd ELRazek. A.H. Effect of neurotoxic metals on neurobehavioral and learning ability in rat pups. J. Egypt. Vet. Med. Assoc. 68: 1-14 (2008).
[16]	Kowalczyk, E.; Kopff, A.; Kedziora, J.; Blaszczyk, J.; Kopff, M.; Niedworok, J. and Fijalkowski, P. Effect of long-term aluminum chloride intoxication on selected biochemical pa-rameters and oxidative –antioxidative balance in experimental animals. Polish Journal of Environmental Studies. 13:41-43 (2004).
[17]	Laviola, G.; Sedowofia, k.; Innes, J.; Clayton, R. and Manning, A. Genetic differences in maternal behavior patterns in mice administered phenobarbital during pregnancy. Psy-chopharmacology. 102: 383-390 (1990).
[18]	Luna, L.G. Berg`s method for spermatozoa. In: Manual od histological staining methods of the armed forces institute of pathology, 3rd edition, 117-118, McGraw-Hill, New york (1968).
[19]	Mahieu, S.; Contini, M.D.C.; Gonzalez, M. and Miller, N.C. Melatonin reduces oxidative damage induced by aluminum in rat kidney. Toxicology Letters.190:9-15 (2009).
[20]	Misawa, T. and Shigeta, S. Behavioral effects of repeated aluminum administration in the rat. Takai.Jo.Exp.Din. Med. 17: 155-159 (1992).
[21]	Morimoto, A.; Nakamon, T.; Morimot, k.; Tan, V. and Mu-rakami, N. The central role of corticotrophin-releasing factor (CRF-41) in psychological stress in rats. Journal of Physi-ology.460:221-229 (1993).
[22]	Pellow, S.; Chopin, P.; File, S.E. and Briley, M. Validation of open-closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J. Neurosci. Methods. 14:149-167 (1985).
[23]	Roig, J.L.; Fuentes, S.; Teresa, C.M.; Colomina, M.; Vicens, P. and Domingo, J.L. Aluminum, restraint stress and aging: Behavioral effects in rats after 1 and 2 years of aluminum exposure. Toxicology. 218:112-124 (2006).
[24]	Schetinger, M.R.C.; Bonan, C.D.; Morsch, V.M.; Boher, D.; Valentin, L.M. and Rodrigues, S.R. Effects of aluminum sulphate on delta-aminolevulinate dehydratase from kidney, brain and liver of adult mice. Braz.J.Med.Biol.Res.32:761-766 (1999).
[25]	Walton, J.R. A longitudinal study of rats chr.onically exposed to aluminum at human dietary levels. Neurosci. Lett. 412:29-33 (2007).
[26]	Waxman, S.G. Correlative neui-oanatomy 23, 3rd ed, Appetton and lang, California (1997).
[27]	Bernuzzi, V.; Desor, D. and Lehr., P.R. Effects of prenatal aluminum exposure on neuromotor maturation in the rat. Neurobehav. Toxicol. Teratol. 8:115-119 (1986).
[28]	Bimonte-Nelson, H.A.; Hunter, C.L.; Nelson, M.E. and Granholm, A.C. Frontal cortex BDNF levels correlate with working memory in an animal model of Down syndrome. Behav.Brain.Res.139:47-57 (2003).
[29]	Bonnie, L. and Carson, S. Aluminum compound. A review of toxicological literature. Abridged final report, Scott, M (2000).
[30]	Bridges, R.S. and Ronsheim, P.M. Prolactin regulation of maternal behavior in rats: Bromocriptine treatment delays and prolactin promotes the rapid onset of behavior. Endocrinology. 126:837-848 (1990).
[31]	Colomina, M.T.; Roig, J.L.; Sanchez, D.J. and Domingo, J.L. Influence of age on aluminum induced neurobehavioral effects and morphological changes in rat brain. Neurotoxicology. 23:775-781 (2002).
[32]	Colomina, M.T.; Rogi. J.L; Torrente, M.; Vicens, P.and Do-mingo, J.L. Concurrent exposure to aluminum and stress during pregnancy in rats: Effects on postnatal development and behavior of the offspring. Neurotoxicol.Teratol.27: 565-574 (2005).
[33]	Delville, Y. Exposure to lead during development alters aggressive behavior in golden hamsters. Neurotoxicol. Teratol. 21:445-449 (1999).
[34]	Domingo, J.L.; Gomez, M. and Colomina, M.T. Risks of aluminum exposure during pregnancy. Contributions to Science. 1: 479-487 (2000).
[35]	Fatma, H.S. Influence of some environmental stressors on response and behavior of laboratory rats. MVSC, Thesis, Cairo university, beni-suef branch, faculty of veterinary medicine (2005).
[36]	Ferreira, A.; Pereira, M.; Agrati, D.; Uriarte, N. and Fer-mandez-Guasti, A. Role of maternal behavior on aggression, fear and anxiety. Physiology and Behavior. 77:197-204 (2002).
[37]	Friend, T.H. Symposium: Response of animals to stress. J. Dairy. Sci. 74:292-303 (1991).
[38]	Gromysz-Kalkowska, K.; Kanoniuk, D.; Szubartowska, E. and Unkiewicz-Winiarczyk, A. Influence of drinking wa-ter-administered aluminum on morphology and respiratory function of blood in rats. Polish Journal of Environmental Studies. 13: 515-519 (2004).
[39]	Harkness, J.E. and Wagner, J.E. Biology and Husbandry. In: the biology and medicine of rabbits and rodents. (2nd ed), Lea and Feiger: 36-51 (1983).
[40]	Kaoud, H.A.; Kamel. M.M. and Abd ELRazek. A.H. Effect of neurotoxic metals on neurobehavioral and learning ability in rat pups. J. Egypt. Vet. Med. Assoc. 68: 1-14 (2008).
[41]	Kowalczyk, E.; Kopff, A.; Kedziora, J.; Blaszczyk, J.; Kopff, M.; Niedworok, J. and Fijalkowski, P. Effect of long-term aluminum chloride intoxication on selected biochemical pa-rameters and oxidative –antioxidative balance in experimental animals. Polish Journal of Environmental Studies. 13:41-43 (2004).
[42]	Laviola, G.; Sedowofia, k.; Innes, J.; Clayton, R. and Manning, A. Genetic differences in maternal behavior patterns in mice administered phenobarbital during pregnancy. Psy-chopharmacology. 102: 383-390 (1990).
[43]	Luna, L.G. Berg`s method for spermatozoa. In: Manual od histological staining methods of the armed forces institute of pathology, 3rd edition, 117-118, McGraw-Hill, New york (1968).
[44]	Mahieu, S.; Contini, M.D.C.; Gonzalez, M. and Miller, N.C. Melatonin reduces oxidative damage induced by aluminum in rat kidney. Toxicology Letters.190:9-15 (2009).
[45]	Misawa, T. and Shigeta, S. Behavioral effects of repeated aluminum administration in the rat. Takai.Jo.Exp.Din. Med. 17: 155-159 (1992).
[46]	Morimoto, A.; Nakamon, T.; Morimot, k.; Tan, V. and Mu-rakami, N. The central role of corticotrophin-releasing factor (CRF-41) in psychological stress in rats. Journal of Physi-ology.460:221-229 (1993).
[47]	Pellow, S.; Chopin, P.; File, S.E. and Briley, M. Validation of open-closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J. Neurosci. Methods. 14:149-167 (1985).
[48]	Roig, J.L.; Fuentes, S.; Teresa, C.M.; Colomina, M.; Vicens, P. and Domingo, J.L. Aluminum, restraint stress and aging: Behavioral effects in rats after 1 and 2 years of aluminum exposure. Toxicology. 218:112-124 (2006).
[49]	Schetinger, M.R.C.; Bonan, C.D.; Morsch, V.M.; Boher, D.; Valentin, L.M. and Rodrigues, S.R. Effects of aluminum sulphate on delta-aminolevulinate dehydratase from kidney, brain and liver of adult mice. Braz. J. Med. Biol. Res. 32: 761-766 (1999).
[50]	Walton, J.R. A longitudinal study of rats chr.onically exposed to aluminum at human dietary levels. Neurosci. Lett. 412:29-33 (2007).

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Amira A. Goma, Usama E. Mahrous. (2013). Ethological Problems and Learning Disability Due to Aluminum Toxicity in Rats. Animal and Veterinary Sciences, 1(2), 12-17. https://doi.org/10.11648/j.avs.20130102.11

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Amira A. Goma; Usama E. Mahrous. Ethological Problems and Learning Disability Due to Aluminum Toxicity in Rats. Anim. Vet. Sci. 2013, 1(2), 12-17. doi: 10.11648/j.avs.20130102.11

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AMA Style

Amira A. Goma, Usama E. Mahrous. Ethological Problems and Learning Disability Due to Aluminum Toxicity in Rats. Anim Vet Sci. 2013;1(2):12-17. doi: 10.11648/j.avs.20130102.11

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@article{10.11648/j.avs.20130102.11,
  author = {Amira A. Goma and Usama E. Mahrous},
  title = {Ethological Problems and Learning Disability Due to Aluminum Toxicity in Rats},
  journal = {Animal and Veterinary Sciences},
  volume = {1},
  number = {2},
  pages = {12-17},
  doi = {10.11648/j.avs.20130102.11},
  url = {https://doi.org/10.11648/j.avs.20130102.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.avs.20130102.11},
  abstract = {A total of 35 Sprague-Dawley adult rats were used to investigate the effect of aluminum toxicity on behavioral patterns of adult female rats and learning ability of offspring. Rats were allotted into 4 groups, group one received 2g/l anhydrous aluminum chloride (n=10), group two received 3g/l anhydrous aluminum chloride (n=10), group thr.ee received 3.5g/l anhydrous aluminum chloride in drinking water (n=10) and control group did not receive anhydrous aluminum chloride (n=5) from 8th day of pregnancy till weaning of pups. The obtained results showed that feeding time increased significantly in 2g/l and 3.5g/l anhydrous aluminum chloride groups than control one, while, litter licking frequency and nursing time increased significantly in 2g/l anhydrous aluminum chloride than other groups. On contrary lying time decreased significantly in rats treated with 2g/l anhydrous aluminum chloride than other groups, licking and scratching decreased in 3g/l and 3.5g/l anhydrous aluminum chloride groups.  In considering, the time spent in closed arms by offspring, pups spent significantly much time than control group, while, time spent in open arms of elevated plus maze decreased significantly in all treated groups than control group. On the other hand, number of entries in open arms significantly decreased in treated groups than control one.},
 year = {2013}
}

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TY  - JOUR
T1  - Ethological Problems and Learning Disability Due to Aluminum Toxicity in Rats
AU  - Amira A. Goma
AU  - Usama E. Mahrous
Y1  - 2013/03/10
PY  - 2013
N1  - https://doi.org/10.11648/j.avs.20130102.11
DO  - 10.11648/j.avs.20130102.11
T2  - Animal and Veterinary Sciences
JF  - Animal and Veterinary Sciences
JO  - Animal and Veterinary Sciences
SP  - 12
EP  - 17
PB  - Science Publishing Group
SN  - 2328-5850
UR  - https://doi.org/10.11648/j.avs.20130102.11
AB  - A total of 35 Sprague-Dawley adult rats were used to investigate the effect of aluminum toxicity on behavioral patterns of adult female rats and learning ability of offspring. Rats were allotted into 4 groups, group one received 2g/l anhydrous aluminum chloride (n=10), group two received 3g/l anhydrous aluminum chloride (n=10), group thr.ee received 3.5g/l anhydrous aluminum chloride in drinking water (n=10) and control group did not receive anhydrous aluminum chloride (n=5) from 8th day of pregnancy till weaning of pups. The obtained results showed that feeding time increased significantly in 2g/l and 3.5g/l anhydrous aluminum chloride groups than control one, while, litter licking frequency and nursing time increased significantly in 2g/l anhydrous aluminum chloride than other groups. On contrary lying time decreased significantly in rats treated with 2g/l anhydrous aluminum chloride than other groups, licking and scratching decreased in 3g/l and 3.5g/l anhydrous aluminum chloride groups.  In considering, the time spent in closed arms by offspring, pups spent significantly much time than control group, while, time spent in open arms of elevated plus maze decreased significantly in all treated groups than control group. On the other hand, number of entries in open arms significantly decreased in treated groups than control one.
VL  - 1
IS  - 2
ER  -

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Author Information

Amira A. Goma

Dept. of Animal Husbandry and wealth development, Faculty of Veterinary Medicine, Alexandria University, Egypt
Usama E. Mahrous

Dept. of Animal Husbandry and wealth development, Faculty of Veterinary Medicine, Damanhour University, Egypt

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Amira A. Goma, Usama E. Mahrous. (2013). Ethological Problems and Learning Disability Due to Aluminum Toxicity in Rats. Animal and Veterinary Sciences, 1(2), 12-17. https://doi.org/10.11648/j.avs.20130102.11

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Amira A. Goma; Usama E. Mahrous. Ethological Problems and Learning Disability Due to Aluminum Toxicity in Rats. Anim. Vet. Sci. 2013, 1(2), 12-17. doi: 10.11648/j.avs.20130102.11

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AMA Style

Amira A. Goma, Usama E. Mahrous. Ethological Problems and Learning Disability Due to Aluminum Toxicity in Rats. Anim Vet Sci. 2013;1(2):12-17. doi: 10.11648/j.avs.20130102.11

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@article{10.11648/j.avs.20130102.11,
  author = {Amira A. Goma and Usama E. Mahrous},
  title = {Ethological Problems and Learning Disability Due to Aluminum Toxicity in Rats},
  journal = {Animal and Veterinary Sciences},
  volume = {1},
  number = {2},
  pages = {12-17},
  doi = {10.11648/j.avs.20130102.11},
  url = {https://doi.org/10.11648/j.avs.20130102.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.avs.20130102.11},
  abstract = {A total of 35 Sprague-Dawley adult rats were used to investigate the effect of aluminum toxicity on behavioral patterns of adult female rats and learning ability of offspring. Rats were allotted into 4 groups, group one received 2g/l anhydrous aluminum chloride (n=10), group two received 3g/l anhydrous aluminum chloride (n=10), group thr.ee received 3.5g/l anhydrous aluminum chloride in drinking water (n=10) and control group did not receive anhydrous aluminum chloride (n=5) from 8th day of pregnancy till weaning of pups. The obtained results showed that feeding time increased significantly in 2g/l and 3.5g/l anhydrous aluminum chloride groups than control one, while, litter licking frequency and nursing time increased significantly in 2g/l anhydrous aluminum chloride than other groups. On contrary lying time decreased significantly in rats treated with 2g/l anhydrous aluminum chloride than other groups, licking and scratching decreased in 3g/l and 3.5g/l anhydrous aluminum chloride groups.  In considering, the time spent in closed arms by offspring, pups spent significantly much time than control group, while, time spent in open arms of elevated plus maze decreased significantly in all treated groups than control group. On the other hand, number of entries in open arms significantly decreased in treated groups than control one.},
 year = {2013}
}

Copy | Download

TY  - JOUR
T1  - Ethological Problems and Learning Disability Due to Aluminum Toxicity in Rats
AU  - Amira A. Goma
AU  - Usama E. Mahrous
Y1  - 2013/03/10
PY  - 2013
N1  - https://doi.org/10.11648/j.avs.20130102.11
DO  - 10.11648/j.avs.20130102.11
T2  - Animal and Veterinary Sciences
JF  - Animal and Veterinary Sciences
JO  - Animal and Veterinary Sciences
SP  - 12
EP  - 17
PB  - Science Publishing Group
SN  - 2328-5850
UR  - https://doi.org/10.11648/j.avs.20130102.11
AB  - A total of 35 Sprague-Dawley adult rats were used to investigate the effect of aluminum toxicity on behavioral patterns of adult female rats and learning ability of offspring. Rats were allotted into 4 groups, group one received 2g/l anhydrous aluminum chloride (n=10), group two received 3g/l anhydrous aluminum chloride (n=10), group thr.ee received 3.5g/l anhydrous aluminum chloride in drinking water (n=10) and control group did not receive anhydrous aluminum chloride (n=5) from 8th day of pregnancy till weaning of pups. The obtained results showed that feeding time increased significantly in 2g/l and 3.5g/l anhydrous aluminum chloride groups than control one, while, litter licking frequency and nursing time increased significantly in 2g/l anhydrous aluminum chloride than other groups. On contrary lying time decreased significantly in rats treated with 2g/l anhydrous aluminum chloride than other groups, licking and scratching decreased in 3g/l and 3.5g/l anhydrous aluminum chloride groups.  In considering, the time spent in closed arms by offspring, pups spent significantly much time than control group, while, time spent in open arms of elevated plus maze decreased significantly in all treated groups than control group. On the other hand, number of entries in open arms significantly decreased in treated groups than control one.
VL  - 1
IS  - 2
ER  -

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