In Differential Diagnosis of Dementia Application of Easy Z-score Imaging System in Single Photon Emission Computed Tomography Brain Perfusion Scan

Nasreen Sultana; Hiroshi Matsuda; Azmal Kabir Sarker; Jasmine Ara Haque; Rafiqul Islam

doi:doi:10.11648/j.ajpn.20190704.14

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In Differential Diagnosis of Dementia Application of Easy Z-score Imaging System in Single Photon Emission Computed Tomography Brain Perfusion Scan

Nasreen Sultana, Hiroshi Matsuda, Azmal Kabir Sarker, Jasmine Ara Haque, Rafiqul Islam

Published in American Journal of Psychiatry and Neuroscience (Volume 7, Issue 4)

Received: 20 October 2019 Accepted: 6 November 2019 Published: 12 November 2019

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Abstract

Application of easy Z score imaging system (eZIS) on brain perfusion SPECT images for quantitative evaluation of rCBF has attempted to explore the differential diagnosis of dementia with various degenerative diseases and to evaluate discrimination of early Alzheimer’s disease (AD) from other types of dementia. This retrospective study was done with various degenerative diseases that underwent brain perfusion SPECT using 99mTc ethyl cysteinate dimer were included. Brain perfusion SPECT was performed in 58 patients (M/F = 48/10) with mean age of 61.2±10.4 years (41-90). Decreased rCBF was observed in the area suspected early AD in 20 cases (34%) and in the frontal gyrus and insula in 10 cases (17%). And decreased rCBF was observed in occipital lobe and, precuneus, gyrus and posterior cingulate cortex in 8 cases (14%). Discrete areas of decreased rCBF were seen in 14 cases (24%) and the rest of 6 cases (11%) showed normal rCBF. Clinically suspected AD patients were divided into two groups on basis of MMSE score (group A, mild stage of AD, MMSE =20-26 and group B, moderate to severe stage of AD, MMSE=10-19). Mean MMSE and mean Z scores were 22.9±1.11 and 1.01±0.35 in group A (n = 12) while 17.56±0.96 and 2.62±0.59 in group B (n= 8). There was negative correlation between MMSE and eZIS score; r = - 0.69 in group A (p = 0.002); r = - 0.58 in group B (p = 0.019) and r = - 0.93 overall (p = 0.000). Quantification of rCBF with eZIS score was well associated with clinical MMSE scoring in this study group with clinical likelihood of having AD. In rest of the cases, SPECT findings and surface view analysis by eZIS, the affected area of decreased rCBF were consistent with clinically suspected different types of degenerative disease manifesting dementia.

Published in	American Journal of Psychiatry and Neuroscience (Volume 7, Issue 4)
DOI	10.11648/j.ajpn.20190704.14
Page(s)	100-107
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

eZIS, Alzheimer's Disease, Brain Perfusion, SPECT

References

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[7]	Kanetaka H, Matsuda H, Asada T, et al: Effects of partial volume correction on discrimination between very early Alzheimer’s dementia and controls using brain perfusion SPECT. Eur J Nucl Med Mol Imaging 2004; 31: 975–980.
[8]	Matsuda H, Mizumura S, Nagao T, et al: Automated discrimination between very early Alzheimer’s disease and controls using an easy Z-score imaging system for multicenter brain perfusion SPECT. AJNR Am J Neuroradiol 2007; 28: 731–736.
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Nasreen Sultana, Hiroshi Matsuda, Azmal Kabir Sarker, Jasmine Ara Haque, Rafiqul Islam. (2019). In Differential Diagnosis of Dementia Application of Easy Z-score Imaging System in Single Photon Emission Computed Tomography Brain Perfusion Scan. American Journal of Psychiatry and Neuroscience, 7(4), 100-107. https://doi.org/10.11648/j.ajpn.20190704.14

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ACS Style

Nasreen Sultana; Hiroshi Matsuda; Azmal Kabir Sarker; Jasmine Ara Haque; Rafiqul Islam. In Differential Diagnosis of Dementia Application of Easy Z-score Imaging System in Single Photon Emission Computed Tomography Brain Perfusion Scan. Am. J. Psychiatry Neurosci. 2019, 7(4), 100-107. doi: 10.11648/j.ajpn.20190704.14

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AMA Style

Nasreen Sultana, Hiroshi Matsuda, Azmal Kabir Sarker, Jasmine Ara Haque, Rafiqul Islam. In Differential Diagnosis of Dementia Application of Easy Z-score Imaging System in Single Photon Emission Computed Tomography Brain Perfusion Scan. Am J Psychiatry Neurosci. 2019;7(4):100-107. doi: 10.11648/j.ajpn.20190704.14

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@article{10.11648/j.ajpn.20190704.14,
  author = {Nasreen Sultana and Hiroshi Matsuda and Azmal Kabir Sarker and Jasmine Ara Haque and Rafiqul Islam},
  title = {In Differential Diagnosis of Dementia Application of Easy Z-score Imaging System in Single Photon Emission Computed Tomography Brain Perfusion Scan},
  journal = {American Journal of Psychiatry and Neuroscience},
  volume = {7},
  number = {4},
  pages = {100-107},
  doi = {10.11648/j.ajpn.20190704.14},
  url = {https://doi.org/10.11648/j.ajpn.20190704.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajpn.20190704.14},
  abstract = {Application of easy Z score imaging system (eZIS) on brain perfusion SPECT images for quantitative evaluation of rCBF has attempted to explore the differential diagnosis of dementia with various degenerative diseases and to evaluate discrimination of early Alzheimer’s disease (AD) from other types of dementia. This retrospective study was done with various degenerative diseases that underwent brain perfusion SPECT using 99mTc ethyl cysteinate dimer were included. Brain perfusion SPECT was performed in 58 patients (M/F = 48/10) with mean age of 61.2±10.4 years (41-90). Decreased rCBF was observed in the area suspected early AD in 20 cases (34%) and in the frontal gyrus and insula in 10 cases (17%). And decreased rCBF was observed in occipital lobe and, precuneus, gyrus and posterior cingulate cortex in 8 cases (14%). Discrete areas of decreased rCBF were seen in 14 cases (24%) and the rest of 6 cases (11%) showed normal rCBF. Clinically suspected AD patients were divided into two groups on basis of MMSE score (group A, mild stage of AD, MMSE =20-26 and group B, moderate to severe stage of AD, MMSE=10-19). Mean MMSE and mean Z scores were 22.9±1.11 and 1.01±0.35 in group A (n = 12) while 17.56±0.96 and 2.62±0.59 in group B (n= 8). There was negative correlation between MMSE and eZIS score; r = - 0.69 in group A (p = 0.002); r = - 0.58 in group B (p = 0.019) and r = - 0.93 overall (p = 0.000). Quantification of rCBF with eZIS score was well associated with clinical MMSE scoring in this study group with clinical likelihood of having AD. In rest of the cases, SPECT findings and surface view analysis by eZIS, the affected area of decreased rCBF were consistent with clinically suspected different types of degenerative disease manifesting dementia.},
 year = {2019}
}

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TY  - JOUR
T1  - In Differential Diagnosis of Dementia Application of Easy Z-score Imaging System in Single Photon Emission Computed Tomography Brain Perfusion Scan
AU  - Nasreen Sultana
AU  - Hiroshi Matsuda
AU  - Azmal Kabir Sarker
AU  - Jasmine Ara Haque
AU  - Rafiqul Islam
Y1  - 2019/11/12
PY  - 2019
N1  - https://doi.org/10.11648/j.ajpn.20190704.14
DO  - 10.11648/j.ajpn.20190704.14
T2  - American Journal of Psychiatry and Neuroscience
JF  - American Journal of Psychiatry and Neuroscience
JO  - American Journal of Psychiatry and Neuroscience
SP  - 100
EP  - 107
PB  - Science Publishing Group
SN  - 2330-426X
UR  - https://doi.org/10.11648/j.ajpn.20190704.14
AB  - Application of easy Z score imaging system (eZIS) on brain perfusion SPECT images for quantitative evaluation of rCBF has attempted to explore the differential diagnosis of dementia with various degenerative diseases and to evaluate discrimination of early Alzheimer’s disease (AD) from other types of dementia. This retrospective study was done with various degenerative diseases that underwent brain perfusion SPECT using 99mTc ethyl cysteinate dimer were included. Brain perfusion SPECT was performed in 58 patients (M/F = 48/10) with mean age of 61.2±10.4 years (41-90). Decreased rCBF was observed in the area suspected early AD in 20 cases (34%) and in the frontal gyrus and insula in 10 cases (17%). And decreased rCBF was observed in occipital lobe and, precuneus, gyrus and posterior cingulate cortex in 8 cases (14%). Discrete areas of decreased rCBF were seen in 14 cases (24%) and the rest of 6 cases (11%) showed normal rCBF. Clinically suspected AD patients were divided into two groups on basis of MMSE score (group A, mild stage of AD, MMSE =20-26 and group B, moderate to severe stage of AD, MMSE=10-19). Mean MMSE and mean Z scores were 22.9±1.11 and 1.01±0.35 in group A (n = 12) while 17.56±0.96 and 2.62±0.59 in group B (n= 8). There was negative correlation between MMSE and eZIS score; r = - 0.69 in group A (p = 0.002); r = - 0.58 in group B (p = 0.019) and r = - 0.93 overall (p = 0.000). Quantification of rCBF with eZIS score was well associated with clinical MMSE scoring in this study group with clinical likelihood of having AD. In rest of the cases, SPECT findings and surface view analysis by eZIS, the affected area of decreased rCBF were consistent with clinically suspected different types of degenerative disease manifesting dementia.
VL  - 7
IS  - 4
ER  -

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Author Information

Nasreen Sultana

National Institute of Nuclear Medicine and Allied Sciences (NINMAS), BSMMU Campus Dhaka, Bangladesh
Hiroshi Matsuda

Integrative Brain Imaging Center, National Center of Neurology and Psychiatry, Tokyo, Japan
Azmal Kabir Sarker

Institute of Nuclear Medicine and Allied Sciences, Mitford, SSMC Campus, Dhaka, Bangladesh
Jasmine Ara Haque

National Institute of Nuclear Medicine and Allied Sciences (NINMAS), BSMMU Campus Dhaka, Bangladesh
Rafiqul Islam

Neurology, BSM Medical University, Dhaka, Bangladesh

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Plain Text BibTeX RIS

APA Style

Nasreen Sultana, Hiroshi Matsuda, Azmal Kabir Sarker, Jasmine Ara Haque, Rafiqul Islam. (2019). In Differential Diagnosis of Dementia Application of Easy Z-score Imaging System in Single Photon Emission Computed Tomography Brain Perfusion Scan. American Journal of Psychiatry and Neuroscience, 7(4), 100-107. https://doi.org/10.11648/j.ajpn.20190704.14

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ACS Style

Nasreen Sultana; Hiroshi Matsuda; Azmal Kabir Sarker; Jasmine Ara Haque; Rafiqul Islam. In Differential Diagnosis of Dementia Application of Easy Z-score Imaging System in Single Photon Emission Computed Tomography Brain Perfusion Scan. Am. J. Psychiatry Neurosci. 2019, 7(4), 100-107. doi: 10.11648/j.ajpn.20190704.14

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AMA Style

Nasreen Sultana, Hiroshi Matsuda, Azmal Kabir Sarker, Jasmine Ara Haque, Rafiqul Islam. In Differential Diagnosis of Dementia Application of Easy Z-score Imaging System in Single Photon Emission Computed Tomography Brain Perfusion Scan. Am J Psychiatry Neurosci. 2019;7(4):100-107. doi: 10.11648/j.ajpn.20190704.14

Copy | Download

@article{10.11648/j.ajpn.20190704.14,
  author = {Nasreen Sultana and Hiroshi Matsuda and Azmal Kabir Sarker and Jasmine Ara Haque and Rafiqul Islam},
  title = {In Differential Diagnosis of Dementia Application of Easy Z-score Imaging System in Single Photon Emission Computed Tomography Brain Perfusion Scan},
  journal = {American Journal of Psychiatry and Neuroscience},
  volume = {7},
  number = {4},
  pages = {100-107},
  doi = {10.11648/j.ajpn.20190704.14},
  url = {https://doi.org/10.11648/j.ajpn.20190704.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajpn.20190704.14},
  abstract = {Application of easy Z score imaging system (eZIS) on brain perfusion SPECT images for quantitative evaluation of rCBF has attempted to explore the differential diagnosis of dementia with various degenerative diseases and to evaluate discrimination of early Alzheimer’s disease (AD) from other types of dementia. This retrospective study was done with various degenerative diseases that underwent brain perfusion SPECT using 99mTc ethyl cysteinate dimer were included. Brain perfusion SPECT was performed in 58 patients (M/F = 48/10) with mean age of 61.2±10.4 years (41-90). Decreased rCBF was observed in the area suspected early AD in 20 cases (34%) and in the frontal gyrus and insula in 10 cases (17%). And decreased rCBF was observed in occipital lobe and, precuneus, gyrus and posterior cingulate cortex in 8 cases (14%). Discrete areas of decreased rCBF were seen in 14 cases (24%) and the rest of 6 cases (11%) showed normal rCBF. Clinically suspected AD patients were divided into two groups on basis of MMSE score (group A, mild stage of AD, MMSE =20-26 and group B, moderate to severe stage of AD, MMSE=10-19). Mean MMSE and mean Z scores were 22.9±1.11 and 1.01±0.35 in group A (n = 12) while 17.56±0.96 and 2.62±0.59 in group B (n= 8). There was negative correlation between MMSE and eZIS score; r = - 0.69 in group A (p = 0.002); r = - 0.58 in group B (p = 0.019) and r = - 0.93 overall (p = 0.000). Quantification of rCBF with eZIS score was well associated with clinical MMSE scoring in this study group with clinical likelihood of having AD. In rest of the cases, SPECT findings and surface view analysis by eZIS, the affected area of decreased rCBF were consistent with clinically suspected different types of degenerative disease manifesting dementia.},
 year = {2019}
}

Copy | Download

TY  - JOUR
T1  - In Differential Diagnosis of Dementia Application of Easy Z-score Imaging System in Single Photon Emission Computed Tomography Brain Perfusion Scan
AU  - Nasreen Sultana
AU  - Hiroshi Matsuda
AU  - Azmal Kabir Sarker
AU  - Jasmine Ara Haque
AU  - Rafiqul Islam
Y1  - 2019/11/12
PY  - 2019
N1  - https://doi.org/10.11648/j.ajpn.20190704.14
DO  - 10.11648/j.ajpn.20190704.14
T2  - American Journal of Psychiatry and Neuroscience
JF  - American Journal of Psychiatry and Neuroscience
JO  - American Journal of Psychiatry and Neuroscience
SP  - 100
EP  - 107
PB  - Science Publishing Group
SN  - 2330-426X
UR  - https://doi.org/10.11648/j.ajpn.20190704.14
AB  - Application of easy Z score imaging system (eZIS) on brain perfusion SPECT images for quantitative evaluation of rCBF has attempted to explore the differential diagnosis of dementia with various degenerative diseases and to evaluate discrimination of early Alzheimer’s disease (AD) from other types of dementia. This retrospective study was done with various degenerative diseases that underwent brain perfusion SPECT using 99mTc ethyl cysteinate dimer were included. Brain perfusion SPECT was performed in 58 patients (M/F = 48/10) with mean age of 61.2±10.4 years (41-90). Decreased rCBF was observed in the area suspected early AD in 20 cases (34%) and in the frontal gyrus and insula in 10 cases (17%). And decreased rCBF was observed in occipital lobe and, precuneus, gyrus and posterior cingulate cortex in 8 cases (14%). Discrete areas of decreased rCBF were seen in 14 cases (24%) and the rest of 6 cases (11%) showed normal rCBF. Clinically suspected AD patients were divided into two groups on basis of MMSE score (group A, mild stage of AD, MMSE =20-26 and group B, moderate to severe stage of AD, MMSE=10-19). Mean MMSE and mean Z scores were 22.9±1.11 and 1.01±0.35 in group A (n = 12) while 17.56±0.96 and 2.62±0.59 in group B (n= 8). There was negative correlation between MMSE and eZIS score; r = - 0.69 in group A (p = 0.002); r = - 0.58 in group B (p = 0.019) and r = - 0.93 overall (p = 0.000). Quantification of rCBF with eZIS score was well associated with clinical MMSE scoring in this study group with clinical likelihood of having AD. In rest of the cases, SPECT findings and surface view analysis by eZIS, the affected area of decreased rCBF were consistent with clinically suspected different types of degenerative disease manifesting dementia.
VL  - 7
IS  - 4
ER  -

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