Differential Pulse Voltammetric Determination of Paracetamol Using Activated Glassy Carbon Electrode

Meselu Eskezia Ayalew; Dereje Yenealem Ayitegeb

doi:doi:10.11648/j.ajpc.20211002.11

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Differential Pulse Voltammetric Determination of Paracetamol Using Activated Glassy Carbon Electrode

Meselu Eskezia Ayalew, Dereje Yenealem Ayitegeb

Published in American Journal of Physical Chemistry (Volume 10, Issue 2)

Received: 5 April 2021 Accepted: 11 May 2021 Published: 20 May 2021

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Abstract

The electrochemical property of paracetamol was investigated at a glassy carbon electrode and activated glassy carbon electrode. Differential pulse voltammetry and cyclic voltammetry were used as diagnostic techniques in the determination of paracetamol. The activated glassy carbon electrode exhibited excellent electro-catalytic behaviour for the oxidation of PAR as evidenced by the enhancement of the oxidation peak current and the shift in the oxidation peak potential to less positive values by (13mv) in comparison with a bare GCE. In the present work the activated glassy carbon electrode was prepared by activating 200 s in a time base technique at a potential of 1750 mV. The electrode process of paracetamol was studied and some the experimental parameters which affect the response paracetamol, such as pH, effect of PAR concentration and scan rate on AGC electrode. The analysis of cyclic voltammogram gave fundamental electrochemical parameters including the electroactive surface coverage, the electron transfer coefficient and the heterogeneous rate constant (k_s). The variation of scan rate study shows that the system undergoes adsorption controlled process. The equation of the calibration curve was found to be: I_p=0.429C + 6.43, R²=0.993. The LOD and LOQ for the developed method were determined to be 8×10^-8 mol L^-1 and 2.6×10^-7mol L^-1 respectively. Phosphate buffer pH 7.0 was selected for analytical purpose.

Published in	American Journal of Physical Chemistry (Volume 10, Issue 2)
DOI	10.11648/j.ajpc.20211002.11
Page(s)	16-24
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Paracetamol, Activated Glassy Carbon Electrode, Differential Pulse Voltammetry

References

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APA Style

Meselu Eskezia Ayalew, Dereje Yenealem Ayitegeb. (2021). Differential Pulse Voltammetric Determination of Paracetamol Using Activated Glassy Carbon Electrode. American Journal of Physical Chemistry, 10(2), 16-24. https://doi.org/10.11648/j.ajpc.20211002.11

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ACS Style

Meselu Eskezia Ayalew; Dereje Yenealem Ayitegeb. Differential Pulse Voltammetric Determination of Paracetamol Using Activated Glassy Carbon Electrode. Am. J. Phys. Chem. 2021, 10(2), 16-24. doi: 10.11648/j.ajpc.20211002.11

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AMA Style

Meselu Eskezia Ayalew, Dereje Yenealem Ayitegeb. Differential Pulse Voltammetric Determination of Paracetamol Using Activated Glassy Carbon Electrode. Am J Phys Chem. 2021;10(2):16-24. doi: 10.11648/j.ajpc.20211002.11

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@article{10.11648/j.ajpc.20211002.11,
  author = {Meselu Eskezia Ayalew and Dereje Yenealem Ayitegeb},
  title = {Differential Pulse Voltammetric Determination of Paracetamol Using Activated Glassy Carbon Electrode},
  journal = {American Journal of Physical Chemistry},
  volume = {10},
  number = {2},
  pages = {16-24},
  doi = {10.11648/j.ajpc.20211002.11},
  url = {https://doi.org/10.11648/j.ajpc.20211002.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajpc.20211002.11},
  abstract = {The electrochemical property of paracetamol was investigated at a glassy carbon electrode and activated glassy carbon electrode. Differential pulse voltammetry and cyclic voltammetry were used as diagnostic techniques in the determination of paracetamol. The activated glassy carbon electrode exhibited excellent electro-catalytic behaviour for the oxidation of PAR as evidenced by the enhancement of the oxidation peak current and the shift in the oxidation peak potential to less positive values by (13mv) in comparison with a bare GCE. In the present work the activated glassy carbon electrode was prepared by activating 200 s in a time base technique at a potential of 1750 mV. The electrode process of paracetamol was studied and some the experimental parameters which affect the response paracetamol, such as pH, effect of PAR concentration and scan rate on AGC electrode. The analysis of cyclic voltammogram gave fundamental electrochemical parameters including the electroactive surface coverage, the electron transfer coefficient and the heterogeneous rate constant (ks). The variation of scan rate study shows that the system undergoes adsorption controlled process. The equation of the calibration curve was found to be: Ip=0.429C + 6.43, R2=0.993. The LOD and LOQ for the developed method were determined to be 8×10-8 mol L-1 and 2.6×10-7mol L-1 respectively. Phosphate buffer pH 7.0 was selected for analytical purpose.},
 year = {2021}
}

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TY  - JOUR
T1  - Differential Pulse Voltammetric Determination of Paracetamol Using Activated Glassy Carbon Electrode
AU  - Meselu Eskezia Ayalew
AU  - Dereje Yenealem Ayitegeb
Y1  - 2021/05/20
PY  - 2021
N1  - https://doi.org/10.11648/j.ajpc.20211002.11
DO  - 10.11648/j.ajpc.20211002.11
T2  - American Journal of Physical Chemistry
JF  - American Journal of Physical Chemistry
JO  - American Journal of Physical Chemistry
SP  - 16
EP  - 24
PB  - Science Publishing Group
SN  - 2327-2449
UR  - https://doi.org/10.11648/j.ajpc.20211002.11
AB  - The electrochemical property of paracetamol was investigated at a glassy carbon electrode and activated glassy carbon electrode. Differential pulse voltammetry and cyclic voltammetry were used as diagnostic techniques in the determination of paracetamol. The activated glassy carbon electrode exhibited excellent electro-catalytic behaviour for the oxidation of PAR as evidenced by the enhancement of the oxidation peak current and the shift in the oxidation peak potential to less positive values by (13mv) in comparison with a bare GCE. In the present work the activated glassy carbon electrode was prepared by activating 200 s in a time base technique at a potential of 1750 mV. The electrode process of paracetamol was studied and some the experimental parameters which affect the response paracetamol, such as pH, effect of PAR concentration and scan rate on AGC electrode. The analysis of cyclic voltammogram gave fundamental electrochemical parameters including the electroactive surface coverage, the electron transfer coefficient and the heterogeneous rate constant (ks). The variation of scan rate study shows that the system undergoes adsorption controlled process. The equation of the calibration curve was found to be: Ip=0.429C + 6.43, R2=0.993. The LOD and LOQ for the developed method were determined to be 8×10-8 mol L-1 and 2.6×10-7mol L-1 respectively. Phosphate buffer pH 7.0 was selected for analytical purpose.
VL  - 10
IS  - 2
ER  -

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Author Information

Meselu Eskezia Ayalew

Department of Chemistry, Oda Bultum University, Chiro, Ethiopia
Dereje Yenealem Ayitegeb

Department of Chemistry, University of Gondar, Gondar, Ethiopia

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APA Style

Meselu Eskezia Ayalew, Dereje Yenealem Ayitegeb. (2021). Differential Pulse Voltammetric Determination of Paracetamol Using Activated Glassy Carbon Electrode. American Journal of Physical Chemistry, 10(2), 16-24. https://doi.org/10.11648/j.ajpc.20211002.11

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ACS Style

Meselu Eskezia Ayalew; Dereje Yenealem Ayitegeb. Differential Pulse Voltammetric Determination of Paracetamol Using Activated Glassy Carbon Electrode. Am. J. Phys. Chem. 2021, 10(2), 16-24. doi: 10.11648/j.ajpc.20211002.11

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AMA Style

Meselu Eskezia Ayalew, Dereje Yenealem Ayitegeb. Differential Pulse Voltammetric Determination of Paracetamol Using Activated Glassy Carbon Electrode. Am J Phys Chem. 2021;10(2):16-24. doi: 10.11648/j.ajpc.20211002.11

Copy | Download

@article{10.11648/j.ajpc.20211002.11,
  author = {Meselu Eskezia Ayalew and Dereje Yenealem Ayitegeb},
  title = {Differential Pulse Voltammetric Determination of Paracetamol Using Activated Glassy Carbon Electrode},
  journal = {American Journal of Physical Chemistry},
  volume = {10},
  number = {2},
  pages = {16-24},
  doi = {10.11648/j.ajpc.20211002.11},
  url = {https://doi.org/10.11648/j.ajpc.20211002.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajpc.20211002.11},
  abstract = {The electrochemical property of paracetamol was investigated at a glassy carbon electrode and activated glassy carbon electrode. Differential pulse voltammetry and cyclic voltammetry were used as diagnostic techniques in the determination of paracetamol. The activated glassy carbon electrode exhibited excellent electro-catalytic behaviour for the oxidation of PAR as evidenced by the enhancement of the oxidation peak current and the shift in the oxidation peak potential to less positive values by (13mv) in comparison with a bare GCE. In the present work the activated glassy carbon electrode was prepared by activating 200 s in a time base technique at a potential of 1750 mV. The electrode process of paracetamol was studied and some the experimental parameters which affect the response paracetamol, such as pH, effect of PAR concentration and scan rate on AGC electrode. The analysis of cyclic voltammogram gave fundamental electrochemical parameters including the electroactive surface coverage, the electron transfer coefficient and the heterogeneous rate constant (ks). The variation of scan rate study shows that the system undergoes adsorption controlled process. The equation of the calibration curve was found to be: Ip=0.429C + 6.43, R2=0.993. The LOD and LOQ for the developed method were determined to be 8×10-8 mol L-1 and 2.6×10-7mol L-1 respectively. Phosphate buffer pH 7.0 was selected for analytical purpose.},
 year = {2021}
}

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TY  - JOUR
T1  - Differential Pulse Voltammetric Determination of Paracetamol Using Activated Glassy Carbon Electrode
AU  - Meselu Eskezia Ayalew
AU  - Dereje Yenealem Ayitegeb
Y1  - 2021/05/20
PY  - 2021
N1  - https://doi.org/10.11648/j.ajpc.20211002.11
DO  - 10.11648/j.ajpc.20211002.11
T2  - American Journal of Physical Chemistry
JF  - American Journal of Physical Chemistry
JO  - American Journal of Physical Chemistry
SP  - 16
EP  - 24
PB  - Science Publishing Group
SN  - 2327-2449
UR  - https://doi.org/10.11648/j.ajpc.20211002.11
AB  - The electrochemical property of paracetamol was investigated at a glassy carbon electrode and activated glassy carbon electrode. Differential pulse voltammetry and cyclic voltammetry were used as diagnostic techniques in the determination of paracetamol. The activated glassy carbon electrode exhibited excellent electro-catalytic behaviour for the oxidation of PAR as evidenced by the enhancement of the oxidation peak current and the shift in the oxidation peak potential to less positive values by (13mv) in comparison with a bare GCE. In the present work the activated glassy carbon electrode was prepared by activating 200 s in a time base technique at a potential of 1750 mV. The electrode process of paracetamol was studied and some the experimental parameters which affect the response paracetamol, such as pH, effect of PAR concentration and scan rate on AGC electrode. The analysis of cyclic voltammogram gave fundamental electrochemical parameters including the electroactive surface coverage, the electron transfer coefficient and the heterogeneous rate constant (ks). The variation of scan rate study shows that the system undergoes adsorption controlled process. The equation of the calibration curve was found to be: Ip=0.429C + 6.43, R2=0.993. The LOD and LOQ for the developed method were determined to be 8×10-8 mol L-1 and 2.6×10-7mol L-1 respectively. Phosphate buffer pH 7.0 was selected for analytical purpose.
VL  - 10
IS  - 2
ER  -

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