Medicinal plants have been used in healthcare since time immemorial. Studies have been carried out globally to verify their efficacy and some of the findings have led to the production of plant-based medicines. The global market value of medicinal plant products exceeds $100 billion per annum. This study was conducted to know the effect of Moringa oleifera leaf on Serum biochemistry of experimental exposed Wister rats. Moringa oleifera leaf was extracted with distilled water and concentrated to semisolid form with rotary evaporator at 42°C. Twenty apparently healthy rats weighing 128-233g were exposed to different concentration of Moringa oleifera aqueous leaf extract. Control group were exposed to only distill water. The animals were divided into 3 groups of five rats each, with Group-I exposed to 500 mg/kg crude extract. Group-II exposed to 1000 mg/kg crude extract and Group-III exposed to 2000 mg/kg crude extract. There significant difference (p< 0.05) in analyzed serum biochemical parameters (Creatinine, Urea, Aspartate amino transferase and Alanine amino transferase) between the experimental and control group. From this finding, it can be concluded that Moringa oleifera leaf extract up to 2000mg/kg is safe and cause slight changes in serum biochemistry. Toxicity studies of this plant extracts as well as phytochemical studies to reaffirm it effect in several body tissues and organs and identify the bioactive compounds are highly recommended.
| Published in | American Journal of Life Sciences (Volume 8, Issue 5) |
| DOI | 10.11648/j.ajls.20200805.12 |
| Page(s) | 96-101 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2020. Published by Science Publishing Group |
Alanine Amino Transferase, Aqueous, Aspartate Amino Transferase, Concentration, Creatinine, Moringa oleifera, Urea
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APA Style
Ibrahim Maina Hassan, Bashir Saidu, Ja’afaru Abdullahi Ishaq, Ashiru Dahiru, Nafisat Abdulazeez, et al. (2020). Effects of Moringa oleifera Aqueous Leaf Extract on Some Serum-biochemical Constituents on Wister Rats. American Journal of Life Sciences, 8(5), 96-101. https://doi.org/10.11648/j.ajls.20200805.12
ACS Style
Ibrahim Maina Hassan; Bashir Saidu; Ja’afaru Abdullahi Ishaq; Ashiru Dahiru; Nafisat Abdulazeez, et al. Effects of Moringa oleifera Aqueous Leaf Extract on Some Serum-biochemical Constituents on Wister Rats. Am. J. Life Sci. 2020, 8(5), 96-101. doi: 10.11648/j.ajls.20200805.12
AMA Style
Ibrahim Maina Hassan, Bashir Saidu, Ja’afaru Abdullahi Ishaq, Ashiru Dahiru, Nafisat Abdulazeez, et al. Effects of Moringa oleifera Aqueous Leaf Extract on Some Serum-biochemical Constituents on Wister Rats. Am J Life Sci. 2020;8(5):96-101. doi: 10.11648/j.ajls.20200805.12
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Download@article{10.11648/j.ajls.20200805.12,
author = {Ibrahim Maina Hassan and Bashir Saidu and Ja’afaru Abdullahi Ishaq and Ashiru Dahiru and Nafisat Abdulazeez and Halima Ibrahim Yusuf and Jubril Saidu Fatima and Yushau Shuaibu Baraya and Adamu Abdul Abubakar and Adama Musa Abdullahi},
title = {Effects of Moringa oleifera Aqueous Leaf Extract on Some Serum-biochemical Constituents on Wister Rats},
journal = {American Journal of Life Sciences},
volume = {8},
number = {5},
pages = {96-101},
doi = {10.11648/j.ajls.20200805.12},
url = {https://doi.org/10.11648/j.ajls.20200805.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajls.20200805.12},
abstract = {Medicinal plants have been used in healthcare since time immemorial. Studies have been carried out globally to verify their efficacy and some of the findings have led to the production of plant-based medicines. The global market value of medicinal plant products exceeds $100 billion per annum. This study was conducted to know the effect of Moringa oleifera leaf on Serum biochemistry of experimental exposed Wister rats. Moringa oleifera leaf was extracted with distilled water and concentrated to semisolid form with rotary evaporator at 42°C. Twenty apparently healthy rats weighing 128-233g were exposed to different concentration of Moringa oleifera aqueous leaf extract. Control group were exposed to only distill water. The animals were divided into 3 groups of five rats each, with Group-I exposed to 500 mg/kg crude extract. Group-II exposed to 1000 mg/kg crude extract and Group-III exposed to 2000 mg/kg crude extract. There significant difference (pMoringa oleifera leaf extract up to 2000mg/kg is safe and cause slight changes in serum biochemistry. Toxicity studies of this plant extracts as well as phytochemical studies to reaffirm it effect in several body tissues and organs and identify the bioactive compounds are highly recommended.},
year = {2020}
}
TY - JOUR T1 - Effects of Moringa oleifera Aqueous Leaf Extract on Some Serum-biochemical Constituents on Wister Rats AU - Ibrahim Maina Hassan AU - Bashir Saidu AU - Ja’afaru Abdullahi Ishaq AU - Ashiru Dahiru AU - Nafisat Abdulazeez AU - Halima Ibrahim Yusuf AU - Jubril Saidu Fatima AU - Yushau Shuaibu Baraya AU - Adamu Abdul Abubakar AU - Adama Musa Abdullahi Y1 - 2020/08/27 PY - 2020 N1 - https://doi.org/10.11648/j.ajls.20200805.12 DO - 10.11648/j.ajls.20200805.12 T2 - American Journal of Life Sciences JF - American Journal of Life Sciences JO - American Journal of Life Sciences SP - 96 EP - 101 PB - Science Publishing Group SN - 2328-5737 UR - https://doi.org/10.11648/j.ajls.20200805.12 AB - Medicinal plants have been used in healthcare since time immemorial. Studies have been carried out globally to verify their efficacy and some of the findings have led to the production of plant-based medicines. The global market value of medicinal plant products exceeds $100 billion per annum. This study was conducted to know the effect of Moringa oleifera leaf on Serum biochemistry of experimental exposed Wister rats. Moringa oleifera leaf was extracted with distilled water and concentrated to semisolid form with rotary evaporator at 42°C. Twenty apparently healthy rats weighing 128-233g were exposed to different concentration of Moringa oleifera aqueous leaf extract. Control group were exposed to only distill water. The animals were divided into 3 groups of five rats each, with Group-I exposed to 500 mg/kg crude extract. Group-II exposed to 1000 mg/kg crude extract and Group-III exposed to 2000 mg/kg crude extract. There significant difference (pMoringa oleifera leaf extract up to 2000mg/kg is safe and cause slight changes in serum biochemistry. Toxicity studies of this plant extracts as well as phytochemical studies to reaffirm it effect in several body tissues and organs and identify the bioactive compounds are highly recommended. VL - 8 IS - 5 ER -
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