Association Between Family History and the Onset Age of Essential Hypertension in Han Population in Shanghai China

Anle Li; Qian Peng; Yueqin Shao; Yiying Zhang; Xiang Fang

doi:doi:10.11648/j.ajhr.20190705.14

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Association Between Family History and the Onset Age of Essential Hypertension in Han Population in Shanghai China

Anle Li, Qian Peng, Yueqin Shao, Yiying Zhang, Xiang Fang

Published in American Journal of Health Research (Volume 7, Issue 5)

Received: 1 August 2019 Accepted: 23 August 2019 Published: 5 September 2019

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Abstract

Genetic factor is one of important influencing factors of essential hypertension, and family history (FH) is an important marker of genetic factors. To explore the association between family history and the onset age of essential hypertension in Han population in Shanghai China. According to l:l matched pairs design, 342 cases of hypertension and 342 controls were selected and investigate their nuclear family members in the case-control study. The diagnostic information of hypertension in all relatives of these two groups was investigated. The method of genetic epidemiology research was used to explore the effect of family history. The average prevalence of hypertension was 23.32%. The prevalence of hypertension of first-degree relatives was 33.99%; the prevalence of second- degree relatives was 17.60%; the prevalence of third-degree relatives was 13.51%. All prevalence of hypertension of case group relatives were significantly higher than that of control group relatives. The average onset age in population with positive FH is 48.74±11.16 years old, and the average onset age in population with negative FH is 54.38±9.87 years old. The difference about two FH groups showed statistically significant (t=4.589, P<0.001). The average onset age of offspring with father, mother, grandpa, grandma, maternal grandpa or maternal grandma positive was respectively 48.42± 11.16, 49.16±11.12, 39.55±11.95, 39.88±11.90, 43.67±9.77 or 43.64±10.21 years old; and the average onset age of children with father, mother, grandpa, grandma, maternal grandpa or maternal grandma negative was respectively 51.90± 10.81, 51.17±11.04, 51.07±10.59, 51.08±10.60, 50.50±11.09 or 50.57±11.06 years old. The difference about two groups showed statistically significant. Family history has a positive effect on the occurrence of hypertension, and lead to earlier age of onset of offspring. The effects are different among parent and grandparent in Han in Shanghai China.

Published in	American Journal of Health Research (Volume 7, Issue 5)
DOI	10.11648/j.ajhr.20190705.14
Page(s)	79-84
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Hypertension, Family History, Onset Age, Effect

References

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APA Style

Anle Li, Qian Peng, Yueqin Shao, Yiying Zhang, Xiang Fang. (2019). Association Between Family History and the Onset Age of Essential Hypertension in Han Population in Shanghai China. American Journal of Health Research, 7(5), 79-84. https://doi.org/10.11648/j.ajhr.20190705.14

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ACS Style

Anle Li; Qian Peng; Yueqin Shao; Yiying Zhang; Xiang Fang. Association Between Family History and the Onset Age of Essential Hypertension in Han Population in Shanghai China. Am. J. Health Res. 2019, 7(5), 79-84. doi: 10.11648/j.ajhr.20190705.14

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AMA Style

Anle Li, Qian Peng, Yueqin Shao, Yiying Zhang, Xiang Fang. Association Between Family History and the Onset Age of Essential Hypertension in Han Population in Shanghai China. Am J Health Res. 2019;7(5):79-84. doi: 10.11648/j.ajhr.20190705.14

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@article{10.11648/j.ajhr.20190705.14,
  author = {Anle Li and Qian Peng and Yueqin Shao and Yiying Zhang and Xiang Fang},
  title = {Association Between Family History and the Onset Age of Essential Hypertension in Han Population in Shanghai China},
  journal = {American Journal of Health Research},
  volume = {7},
  number = {5},
  pages = {79-84},
  doi = {10.11648/j.ajhr.20190705.14},
  url = {https://doi.org/10.11648/j.ajhr.20190705.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajhr.20190705.14},
  abstract = {Genetic factor is one of important influencing factors of essential hypertension, and family history (FH) is an important marker of genetic factors. To explore the association between family history and the onset age of essential hypertension in Han population in Shanghai China. According to l:l matched pairs design, 342 cases of hypertension and 342 controls were selected and investigate their nuclear family members in the case-control study. The diagnostic information of hypertension in all relatives of these two groups was investigated. The method of genetic epidemiology research was used to explore the effect of family history. The average prevalence of hypertension was 23.32%. The prevalence of hypertension of first-degree relatives was 33.99%; the prevalence of second- degree relatives was 17.60%; the prevalence of third-degree relatives was 13.51%. All prevalence of hypertension of case group relatives were significantly higher than that of control group relatives. The average onset age in population with positive FH is 48.74±11.16 years old, and the average onset age in population with negative FH is 54.38±9.87 years old. The difference about two FH groups showed statistically significant (t=4.589, P<0.001). The average onset age of offspring with father, mother, grandpa, grandma, maternal grandpa or maternal grandma positive was respectively 48.42± 11.16, 49.16±11.12, 39.55±11.95, 39.88±11.90, 43.67±9.77 or 43.64±10.21 years old; and the average onset age of children with father, mother, grandpa, grandma, maternal grandpa or maternal grandma negative was respectively 51.90± 10.81, 51.17±11.04, 51.07±10.59, 51.08±10.60, 50.50±11.09 or 50.57±11.06 years old. The difference about two groups showed statistically significant. Family history has a positive effect on the occurrence of hypertension, and lead to earlier age of onset of offspring. The effects are different among parent and grandparent in Han in Shanghai China.},
 year = {2019}
}

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TY - JOUR
T1 - Association Between Family History and the Onset Age of Essential Hypertension in Han Population in Shanghai China
AU - Anle Li
AU - Qian Peng
AU - Yueqin Shao
AU - Yiying Zhang
AU - Xiang Fang
Y1 - 2019/09/05
PY - 2019
N1 - https://doi.org/10.11648/j.ajhr.20190705.14
DO - 10.11648/j.ajhr.20190705.14
T2 - American Journal of Health Research
JF - American Journal of Health Research
JO - American Journal of Health Research
SP - 79
EP - 84
PB - Science Publishing Group
SN - 2330-8796
UR - https://doi.org/10.11648/j.ajhr.20190705.14
AB - Genetic factor is one of important influencing factors of essential hypertension, and family history (FH) is an important marker of genetic factors. To explore the association between family history and the onset age of essential hypertension in Han population in Shanghai China. According to l:l matched pairs design, 342 cases of hypertension and 342 controls were selected and investigate their nuclear family members in the case-control study. The diagnostic information of hypertension in all relatives of these two groups was investigated. The method of genetic epidemiology research was used to explore the effect of family history. The average prevalence of hypertension was 23.32%. The prevalence of hypertension of first-degree relatives was 33.99%; the prevalence of second- degree relatives was 17.60%; the prevalence of third-degree relatives was 13.51%. All prevalence of hypertension of case group relatives were significantly higher than that of control group relatives. The average onset age in population with positive FH is 48.74±11.16 years old, and the average onset age in population with negative FH is 54.38±9.87 years old. The difference about two FH groups showed statistically significant (t=4.589, P<0.001). The average onset age of offspring with father, mother, grandpa, grandma, maternal grandpa or maternal grandma positive was respectively 48.42± 11.16, 49.16±11.12, 39.55±11.95, 39.88±11.90, 43.67±9.77 or 43.64±10.21 years old; and the average onset age of children with father, mother, grandpa, grandma, maternal grandpa or maternal grandma negative was respectively 51.90± 10.81, 51.17±11.04, 51.07±10.59, 51.08±10.60, 50.50±11.09 or 50.57±11.06 years old. The difference about two groups showed statistically significant. Family history has a positive effect on the occurrence of hypertension, and lead to earlier age of onset of offspring. The effects are different among parent and grandparent in Han in Shanghai China.
VL - 7
IS - 5
ER -

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Author Information

Anle Li

Jiading District Center for Disease Control and Prevention, Shanghai, China
Qian Peng

Jiading District Center for Disease Control and Prevention, Shanghai, China
Yueqin Shao

Jiading District Center for Disease Control and Prevention, Shanghai, China
Yiying Zhang

Jiading District Center for Disease Control and Prevention, Shanghai, China
Xiang Fang

Jiading District Center for Disease Control and Prevention, Shanghai, China

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APA Style

Anle Li, Qian Peng, Yueqin Shao, Yiying Zhang, Xiang Fang. (2019). Association Between Family History and the Onset Age of Essential Hypertension in Han Population in Shanghai China. American Journal of Health Research, 7(5), 79-84. https://doi.org/10.11648/j.ajhr.20190705.14

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ACS Style

Anle Li; Qian Peng; Yueqin Shao; Yiying Zhang; Xiang Fang. Association Between Family History and the Onset Age of Essential Hypertension in Han Population in Shanghai China. Am. J. Health Res. 2019, 7(5), 79-84. doi: 10.11648/j.ajhr.20190705.14

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AMA Style

Anle Li, Qian Peng, Yueqin Shao, Yiying Zhang, Xiang Fang. Association Between Family History and the Onset Age of Essential Hypertension in Han Population in Shanghai China. Am J Health Res. 2019;7(5):79-84. doi: 10.11648/j.ajhr.20190705.14

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@article{10.11648/j.ajhr.20190705.14,
  author = {Anle Li and Qian Peng and Yueqin Shao and Yiying Zhang and Xiang Fang},
  title = {Association Between Family History and the Onset Age of Essential Hypertension in Han Population in Shanghai China},
  journal = {American Journal of Health Research},
  volume = {7},
  number = {5},
  pages = {79-84},
  doi = {10.11648/j.ajhr.20190705.14},
  url = {https://doi.org/10.11648/j.ajhr.20190705.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajhr.20190705.14},
  abstract = {Genetic factor is one of important influencing factors of essential hypertension, and family history (FH) is an important marker of genetic factors. To explore the association between family history and the onset age of essential hypertension in Han population in Shanghai China. According to l:l matched pairs design, 342 cases of hypertension and 342 controls were selected and investigate their nuclear family members in the case-control study. The diagnostic information of hypertension in all relatives of these two groups was investigated. The method of genetic epidemiology research was used to explore the effect of family history. The average prevalence of hypertension was 23.32%. The prevalence of hypertension of first-degree relatives was 33.99%; the prevalence of second- degree relatives was 17.60%; the prevalence of third-degree relatives was 13.51%. All prevalence of hypertension of case group relatives were significantly higher than that of control group relatives. The average onset age in population with positive FH is 48.74±11.16 years old, and the average onset age in population with negative FH is 54.38±9.87 years old. The difference about two FH groups showed statistically significant (t=4.589, P<0.001). The average onset age of offspring with father, mother, grandpa, grandma, maternal grandpa or maternal grandma positive was respectively 48.42± 11.16, 49.16±11.12, 39.55±11.95, 39.88±11.90, 43.67±9.77 or 43.64±10.21 years old; and the average onset age of children with father, mother, grandpa, grandma, maternal grandpa or maternal grandma negative was respectively 51.90± 10.81, 51.17±11.04, 51.07±10.59, 51.08±10.60, 50.50±11.09 or 50.57±11.06 years old. The difference about two groups showed statistically significant. Family history has a positive effect on the occurrence of hypertension, and lead to earlier age of onset of offspring. The effects are different among parent and grandparent in Han in Shanghai China.},
 year = {2019}
}

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