Toxicity Effects of Amlodipine on the Body Weight and Sperm Count in Adult Wistar Rats

Huthman Ibrahim Oluwaseun; Ibrahim Bilikis; Huthman Adebukola Selimot; Otulana Jibril

doi:doi:10.11648/j.ajcem.20130101.11

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Toxicity Effects of Amlodipine on the Body Weight and Sperm Count in Adult Wistar Rats

Huthman Ibrahim Oluwaseun, Ibrahim Bilikis, Huthman Adebukola Selimot, Otulana Jibril

Published in American Journal of Clinical and Experimental Medicine (Volume 1, Issue 1)

Received: 30 April 2013 Published: 10 June 2013

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Abstract

Amlodipine is one of the calcium channel blocker class of antihypertensive used in the treatment of hypertension. Amlodipine is widely used in Nigeria today as an antihypertensive although the side effect on health has been reported, based on researches done. This study was carried out to appraise the toxicity effects of Amlodipine on the body weight and sperm count in Adult Wistar rats. The rats were divided into 3 groups: group 1 was given normal saline while group 2 and 3 were administered with 0.052mg/g/BW and 0.104mg/g/BW of amlodipine respectively. Our preliminary observations showed that Amlodipine did not have any effect on the body weight but lead to a decrease in sperm count. These effects were totally different from the rats used in the control group and by these preliminary observations, toxic dose of Amlodipine has been shown to lead to infertility in rats.

Published in	American Journal of Clinical and Experimental Medicine (Volume 1, Issue 1)
DOI	10.11648/j.ajcem.20130101.11
Page(s)	1-4
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2013. Published by Science Publishing Group

Keywords

Amlodipine, Hypertension, Sperm Count, Infertility, Body Weight

References

[1]	U.S. National Library of Medicine: Drug Information Portal – Amlodipine
[2]	Johnson A. D. and Gomes W.R., The testis, Vols. 1-4 Academic Press, 1970.
[3]	Trainer T. D, Histology of the normal testis, Vol.11, Am J surg Pathol, 1987, pp. 797.
[4]	Carretero O. A., S. Oparil, Essential hypertension. Part I: definition and etiology, Vol.3, Circulation 101, 2000, pp.329–35.
[5]	Pierdomenico S.D., M. Di Nicola, A.L. Esposito, Prognostic Value of Different Indices of Blood Pressure Variability in Hypertensive Patients,Vol.22, American Journal of Hypertension, 2009, pp (8):842–7.
[6]	Kearney P. M., M. Whelton, K. Reynolds, P. Muntner, P.K. Whelton, J. He, Global burden of hypertension: analysis of worldwide data, Vol.365, Lancet, 2005, pp (9455) 217–23.
[7]	Kearney P. M., M. Whelton, K. Reynolds, P.K. Whelton, J. He, Worldwide prevalence of hypertension: A systematic review, Vol.22, J. Hypertens, 2004, pp (1): 11–9.
[8]	Burt V. L., P. Whelton, E.J. Roccella,. Prevalence of hypertension in the US adult population. Results from the Third National Health and Nutrition Examination Survey 1991-1995, Vol.525, Hypertension, 1995, pp(3): 305–13.
[9]	Burt V. L., J. A. Cutler, M. Higgins, Trends in the prevalence, awareness, treatment, and control of hypertension in the adult US population. Data from the health examination surveys, 1960 to 1991: Vol. 26, Hypertension 1995, pp(1): 60–9.
[10]	Ostchega Y., C.F. Dillon, J.P. Hughes, M. Carroll, S. Yoon,. Trends in hypertension prevalence, awareness, treatment, and control in older U.S. adults: data from the National Health and Nutrition Examination Survey 1988 to 2004, Vol.55, Journal of the American Geriatrics Society, 2007 pp(7): 1056–65.
[11]	Almeida S.A., J.M. Teófilo, J.A. Anselmo Franci, L.G. Brentegani, T.L. Lamano- Carvalho,. Antireproductive effect of the calcium channel blocker amlodipine in male rats, Vol. 52, Exp Toxicol Pathol. 2000 pp(4): 353-6.
[12]	Source: Sandoz product information sheet

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Huthman Ibrahim Oluwaseun, Ibrahim Bilikis, Huthman Adebukola Selimot, Otulana Jibril. (2013). Toxicity Effects of Amlodipine on the Body Weight and Sperm Count in Adult Wistar Rats. American Journal of Clinical and Experimental Medicine, 1(1), 1-4. https://doi.org/10.11648/j.ajcem.20130101.11

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ACS Style

Huthman Ibrahim Oluwaseun; Ibrahim Bilikis; Huthman Adebukola Selimot; Otulana Jibril. Toxicity Effects of Amlodipine on the Body Weight and Sperm Count in Adult Wistar Rats. Am. J. Clin. Exp. Med. 2013, 1(1), 1-4. doi: 10.11648/j.ajcem.20130101.11

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AMA Style

Huthman Ibrahim Oluwaseun, Ibrahim Bilikis, Huthman Adebukola Selimot, Otulana Jibril. Toxicity Effects of Amlodipine on the Body Weight and Sperm Count in Adult Wistar Rats. Am J Clin Exp Med. 2013;1(1):1-4. doi: 10.11648/j.ajcem.20130101.11

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@article{10.11648/j.ajcem.20130101.11,
  author = {Huthman Ibrahim Oluwaseun and Ibrahim Bilikis and Huthman Adebukola Selimot and Otulana Jibril},
  title = {Toxicity Effects of Amlodipine on the Body Weight and Sperm Count in Adult Wistar Rats},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {1},
  number = {1},
  pages = {1-4},
  doi = {10.11648/j.ajcem.20130101.11},
  url = {https://doi.org/10.11648/j.ajcem.20130101.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20130101.11},
  abstract = {Amlodipine is one of the calcium channel blocker class of antihypertensive used in the treatment of hypertension. Amlodipine is widely used in Nigeria today as an antihypertensive although the side effect on health has been reported, based on researches done. This study was carried out to appraise the toxicity effects of Amlodipine on the body weight and sperm count in Adult Wistar rats. The rats were divided into 3 groups: group 1 was given normal saline while group 2 and 3 were administered with 0.052mg/g/BW and 0.104mg/g/BW of amlodipine respectively. Our preliminary observations showed that Amlodipine did not have any effect on the body weight but lead to a decrease in sperm count. These effects were totally different from the rats used in the control group and by these preliminary observations, toxic dose of Amlodipine has been shown to lead to infertility in rats.},
 year = {2013}
}

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TY  - JOUR
T1  - Toxicity Effects of Amlodipine on the Body Weight and Sperm Count in Adult Wistar Rats
AU  - Huthman Ibrahim Oluwaseun
AU  - Ibrahim Bilikis
AU  - Huthman Adebukola Selimot
AU  - Otulana Jibril
Y1  - 2013/06/10
PY  - 2013
N1  - https://doi.org/10.11648/j.ajcem.20130101.11
DO  - 10.11648/j.ajcem.20130101.11
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 1
EP  - 4
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20130101.11
AB  - Amlodipine is one of the calcium channel blocker class of antihypertensive used in the treatment of hypertension. Amlodipine is widely used in Nigeria today as an antihypertensive although the side effect on health has been reported, based on researches done. This study was carried out to appraise the toxicity effects of Amlodipine on the body weight and sperm count in Adult Wistar rats. The rats were divided into 3 groups: group 1 was given normal saline while group 2 and 3 were administered with 0.052mg/g/BW and 0.104mg/g/BW of amlodipine respectively. Our preliminary observations showed that Amlodipine did not have any effect on the body weight but lead to a decrease in sperm count. These effects were totally different from the rats used in the control group and by these preliminary observations, toxic dose of Amlodipine has been shown to lead to infertility in rats.
VL  - 1
IS  - 1
ER  -

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Author Information

Huthman Ibrahim Oluwaseun

Department of Anatomy, Olabisi Onabanjo University, Ogun State Nigeria
Ibrahim Bilikis

Department of Pharmacy, Federal Medical Centre Umuahia, Abia State, Nigeria
Huthman Adebukola Selimot

Department of Analytical Chemistry, Federal Institute of Industrial Research Oshodi (FIIRO), Lagos state, Nigeria
Otulana Jibril

Department of Anatomy, Olabisi Onabanjo University, Ogun State Nigeria

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APA Style

Huthman Ibrahim Oluwaseun, Ibrahim Bilikis, Huthman Adebukola Selimot, Otulana Jibril. (2013). Toxicity Effects of Amlodipine on the Body Weight and Sperm Count in Adult Wistar Rats. American Journal of Clinical and Experimental Medicine, 1(1), 1-4. https://doi.org/10.11648/j.ajcem.20130101.11

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ACS Style

Huthman Ibrahim Oluwaseun; Ibrahim Bilikis; Huthman Adebukola Selimot; Otulana Jibril. Toxicity Effects of Amlodipine on the Body Weight and Sperm Count in Adult Wistar Rats. Am. J. Clin. Exp. Med. 2013, 1(1), 1-4. doi: 10.11648/j.ajcem.20130101.11

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AMA Style

Huthman Ibrahim Oluwaseun, Ibrahim Bilikis, Huthman Adebukola Selimot, Otulana Jibril. Toxicity Effects of Amlodipine on the Body Weight and Sperm Count in Adult Wistar Rats. Am J Clin Exp Med. 2013;1(1):1-4. doi: 10.11648/j.ajcem.20130101.11

Copy | Download

@article{10.11648/j.ajcem.20130101.11,
  author = {Huthman Ibrahim Oluwaseun and Ibrahim Bilikis and Huthman Adebukola Selimot and Otulana Jibril},
  title = {Toxicity Effects of Amlodipine on the Body Weight and Sperm Count in Adult Wistar Rats},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {1},
  number = {1},
  pages = {1-4},
  doi = {10.11648/j.ajcem.20130101.11},
  url = {https://doi.org/10.11648/j.ajcem.20130101.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20130101.11},
  abstract = {Amlodipine is one of the calcium channel blocker class of antihypertensive used in the treatment of hypertension. Amlodipine is widely used in Nigeria today as an antihypertensive although the side effect on health has been reported, based on researches done. This study was carried out to appraise the toxicity effects of Amlodipine on the body weight and sperm count in Adult Wistar rats. The rats were divided into 3 groups: group 1 was given normal saline while group 2 and 3 were administered with 0.052mg/g/BW and 0.104mg/g/BW of amlodipine respectively. Our preliminary observations showed that Amlodipine did not have any effect on the body weight but lead to a decrease in sperm count. These effects were totally different from the rats used in the control group and by these preliminary observations, toxic dose of Amlodipine has been shown to lead to infertility in rats.},
 year = {2013}
}

Copy | Download

TY  - JOUR
T1  - Toxicity Effects of Amlodipine on the Body Weight and Sperm Count in Adult Wistar Rats
AU  - Huthman Ibrahim Oluwaseun
AU  - Ibrahim Bilikis
AU  - Huthman Adebukola Selimot
AU  - Otulana Jibril
Y1  - 2013/06/10
PY  - 2013
N1  - https://doi.org/10.11648/j.ajcem.20130101.11
DO  - 10.11648/j.ajcem.20130101.11
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 1
EP  - 4
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20130101.11
AB  - Amlodipine is one of the calcium channel blocker class of antihypertensive used in the treatment of hypertension. Amlodipine is widely used in Nigeria today as an antihypertensive although the side effect on health has been reported, based on researches done. This study was carried out to appraise the toxicity effects of Amlodipine on the body weight and sperm count in Adult Wistar rats. The rats were divided into 3 groups: group 1 was given normal saline while group 2 and 3 were administered with 0.052mg/g/BW and 0.104mg/g/BW of amlodipine respectively. Our preliminary observations showed that Amlodipine did not have any effect on the body weight but lead to a decrease in sperm count. These effects were totally different from the rats used in the control group and by these preliminary observations, toxic dose of Amlodipine has been shown to lead to infertility in rats.
VL  - 1
IS  - 1
ER  -

Copy | Download