Opportunistic infections including urinary tract infections (UTIs) are among the predominant cause of morbidity and mortality among HIV infected patients. Persons living with HIV/AIDS (PLWHA) are prone to infection from non-pathogenic microbes in the environment than normal individuals; and this development has been greatly attributed to the weakened immune system of HIV infected patients which makes it difficult to protect the body against invading commensal organisms. In this study, midstream urine (MSU) samples from HIV infected patients who attended the Federal Teaching Hospital Abakaliki (FETHA), Ebonyi State, Nigeria for routine antiretroviral therapy were evaluated by microbiological analysis for uropathogens. Antibiogram was also investigated on all isolated uropathogens by the Kirby-Bauer disk diffusion method. The uropathogens isolated from the MSU of HIV infected patients in this study were identified as: Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae and Proteus mirabilis. S. aureus was the most prevalent isolated organism (n=34). This was followed by K. pneumoniae (n=17), E. coli (16) and P. mirabilis (n=8). All uropathogens produced varying rates of susceptibility and resistance patterns to the tested antibiotics. High sensitivity was observed with gentamicin, ciprofloxacin, ampicillin and amoxycillin-clavulanic acid. Cefotaxime, ceftazidime, cefazolin, ceftriaxone, cefepime, and cefoxitin (which are all 3rd-generation β-lactams) showed less efficacy against the uropathogens. This study draws attention to the increasing rate of UTIs amongst HIV infected patients in Abakaliki metropolis, Ebonyi State of Nigeria, and the resistance of uropathogens to some available antibiotics. Therefore, there is need to checkmate the menace through proper detection and treatment of affected individuals in order to improve the health status of PLWHA in this environment.
| Published in | American Journal of BioScience (Volume 1, Issue 3) |
| DOI | 10.11648/j.ajbio.20130103.11 |
| Page(s) | 50-53 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2013. Published by Science Publishing Group |
HIV/AIDS, Opportunistic Infections, Uropathogens, Resistance, Nigeria
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APA Style
Iroha Ifeanyichukwu, Nwakeze Emmanuel, Ejikeugwu Chika, Oji Anthonia, Udu-Ibiam Esther, et al. (2013). Frequency and Antibiogram of Uropathogens Isolated from Urine Samples of HIV Infected Patients on Antiretroviral Therapy. American Journal of BioScience, 1(3), 50-53. https://doi.org/10.11648/j.ajbio.20130103.11
ACS Style
Iroha Ifeanyichukwu; Nwakeze Emmanuel; Ejikeugwu Chika; Oji Anthonia; Udu-Ibiam Esther, et al. Frequency and Antibiogram of Uropathogens Isolated from Urine Samples of HIV Infected Patients on Antiretroviral Therapy. Am. J. BioScience 2013, 1(3), 50-53. doi: 10.11648/j.ajbio.20130103.11
AMA Style
Iroha Ifeanyichukwu, Nwakeze Emmanuel, Ejikeugwu Chika, Oji Anthonia, Udu-Ibiam Esther, et al. Frequency and Antibiogram of Uropathogens Isolated from Urine Samples of HIV Infected Patients on Antiretroviral Therapy. Am J BioScience. 2013;1(3):50-53. doi: 10.11648/j.ajbio.20130103.11
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Download@article{10.11648/j.ajbio.20130103.11,
author = {Iroha Ifeanyichukwu and Nwakeze Emmanuel and Ejikeugwu Chika and Oji Anthonia and Udu-Ibiam Esther and Afiukwa Ngozi and Ngwu Justina},
title = {Frequency and Antibiogram of Uropathogens Isolated from Urine Samples of HIV Infected Patients on Antiretroviral Therapy},
journal = {American Journal of BioScience},
volume = {1},
number = {3},
pages = {50-53},
doi = {10.11648/j.ajbio.20130103.11},
url = {https://doi.org/10.11648/j.ajbio.20130103.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbio.20130103.11},
abstract = {Opportunistic infections including urinary tract infections (UTIs) are among the predominant cause of morbidity and mortality among HIV infected patients. Persons living with HIV/AIDS (PLWHA) are prone to infection from non-pathogenic microbes in the environment than normal individuals; and this development has been greatly attributed to the weakened immune system of HIV infected patients which makes it difficult to protect the body against invading commensal organisms. In this study, midstream urine (MSU) samples from HIV infected patients who attended the Federal Teaching Hospital Abakaliki (FETHA), Ebonyi State, Nigeria for routine antiretroviral therapy were evaluated by microbiological analysis for uropathogens. Antibiogram was also investigated on all isolated uropathogens by the Kirby-Bauer disk diffusion method. The uropathogens isolated from the MSU of HIV infected patients in this study were identified as: Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae and Proteus mirabilis. S. aureus was the most prevalent isolated organism (n=34). This was followed by K. pneumoniae (n=17), E. coli (16) and P. mirabilis (n=8). All uropathogens produced varying rates of susceptibility and resistance patterns to the tested antibiotics. High sensitivity was observed with gentamicin, ciprofloxacin, ampicillin and amoxycillin-clavulanic acid. Cefotaxime, ceftazidime, cefazolin, ceftriaxone, cefepime, and cefoxitin (which are all 3rd-generation β-lactams) showed less efficacy against the uropathogens. This study draws attention to the increasing rate of UTIs amongst HIV infected patients in Abakaliki metropolis, Ebonyi State of Nigeria, and the resistance of uropathogens to some available antibiotics. Therefore, there is need to checkmate the menace through proper detection and treatment of affected individuals in order to improve the health status of PLWHA in this environment.},
year = {2013}
}
TY - JOUR T1 - Frequency and Antibiogram of Uropathogens Isolated from Urine Samples of HIV Infected Patients on Antiretroviral Therapy AU - Iroha Ifeanyichukwu AU - Nwakeze Emmanuel AU - Ejikeugwu Chika AU - Oji Anthonia AU - Udu-Ibiam Esther AU - Afiukwa Ngozi AU - Ngwu Justina Y1 - 2013/10/30 PY - 2013 N1 - https://doi.org/10.11648/j.ajbio.20130103.11 DO - 10.11648/j.ajbio.20130103.11 T2 - American Journal of BioScience JF - American Journal of BioScience JO - American Journal of BioScience SP - 50 EP - 53 PB - Science Publishing Group SN - 2330-0167 UR - https://doi.org/10.11648/j.ajbio.20130103.11 AB - Opportunistic infections including urinary tract infections (UTIs) are among the predominant cause of morbidity and mortality among HIV infected patients. Persons living with HIV/AIDS (PLWHA) are prone to infection from non-pathogenic microbes in the environment than normal individuals; and this development has been greatly attributed to the weakened immune system of HIV infected patients which makes it difficult to protect the body against invading commensal organisms. In this study, midstream urine (MSU) samples from HIV infected patients who attended the Federal Teaching Hospital Abakaliki (FETHA), Ebonyi State, Nigeria for routine antiretroviral therapy were evaluated by microbiological analysis for uropathogens. Antibiogram was also investigated on all isolated uropathogens by the Kirby-Bauer disk diffusion method. The uropathogens isolated from the MSU of HIV infected patients in this study were identified as: Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae and Proteus mirabilis. S. aureus was the most prevalent isolated organism (n=34). This was followed by K. pneumoniae (n=17), E. coli (16) and P. mirabilis (n=8). All uropathogens produced varying rates of susceptibility and resistance patterns to the tested antibiotics. High sensitivity was observed with gentamicin, ciprofloxacin, ampicillin and amoxycillin-clavulanic acid. Cefotaxime, ceftazidime, cefazolin, ceftriaxone, cefepime, and cefoxitin (which are all 3rd-generation β-lactams) showed less efficacy against the uropathogens. This study draws attention to the increasing rate of UTIs amongst HIV infected patients in Abakaliki metropolis, Ebonyi State of Nigeria, and the resistance of uropathogens to some available antibiotics. Therefore, there is need to checkmate the menace through proper detection and treatment of affected individuals in order to improve the health status of PLWHA in this environment. VL - 1 IS - 3 ER -
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