Assessment of the Effects of Monosodium Glutamate on Some Biochemical and Hematological Parameters in Adult Wistar Rats

Oyetunji Timothy Kolawole

doi:doi:10.11648/j.ajbio.20130101.13

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Assessment of the Effects of Monosodium Glutamate on Some Biochemical and Hematological Parameters in Adult Wistar Rats

Oyetunji Timothy Kolawole

Published in American Journal of BioScience (Volume 1, Issue 1)

Received: 24 May 2013 Published: 20 June 2013

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Abstract

Monosodium glutamate (MSG) is a compound popularly used to enhance food taste and flavor. Several reports of toxicity studies on MSG are contradictory. Therefore, there is growing concern regarding the safety of MSG as food additive. In the present study, the effect of orally administered MSG on food consumption, body weight and some biochemical and hematological parameters were investigated in adult rats. Following a 28-day treatment with 5-15 mg/kg body weight MSG, there were no significant changes in packed cell volume (PCV), hemoglobin concentration (HB), red blood cell (RBC) and white blood cell (WBC) counts. No significant change was also observed in all the biochemical parameters studied, including indices of hepatic and renal functions. The results of this study suggest that MSG at the doses administered is not hazardous to health.

Published in	American Journal of BioScience (Volume 1, Issue 1)
DOI	10.11648/j.ajbio.20130101.13
Page(s)	11-15
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2013. Published by Science Publishing Group

Keywords

Monosodium Glutamate, Toxicity, Body Weight, Food Additive, Enzymes

References

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APA Style

Oyetunji Timothy Kolawole. (2013). Assessment of the Effects of Monosodium Glutamate on Some Biochemical and Hematological Parameters in Adult Wistar Rats. American Journal of BioScience, 1(1), 11-15. https://doi.org/10.11648/j.ajbio.20130101.13

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ACS Style

Oyetunji Timothy Kolawole. Assessment of the Effects of Monosodium Glutamate on Some Biochemical and Hematological Parameters in Adult Wistar Rats. Am. J. BioScience 2013, 1(1), 11-15. doi: 10.11648/j.ajbio.20130101.13

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AMA Style

Oyetunji Timothy Kolawole. Assessment of the Effects of Monosodium Glutamate on Some Biochemical and Hematological Parameters in Adult Wistar Rats. Am J BioScience. 2013;1(1):11-15. doi: 10.11648/j.ajbio.20130101.13

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@article{10.11648/j.ajbio.20130101.13,
  author = {Oyetunji Timothy Kolawole},
  title = {Assessment of the Effects of Monosodium Glutamate on Some Biochemical and Hematological Parameters in Adult Wistar Rats},
  journal = {American Journal of BioScience},
  volume = {1},
  number = {1},
  pages = {11-15},
  doi = {10.11648/j.ajbio.20130101.13},
  url = {https://doi.org/10.11648/j.ajbio.20130101.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbio.20130101.13},
  abstract = {Monosodium glutamate (MSG) is a compound popularly used to enhance food taste and flavor. Several reports of toxicity studies on MSG are contradictory. Therefore, there is growing concern regarding the safety of MSG as food additive. In the present study, the effect of orally administered MSG on food consumption, body weight and some biochemical and hematological parameters were investigated in adult rats. Following a 28-day treatment with 5-15 mg/kg body weight MSG, there were no significant changes in packed cell volume (PCV), hemoglobin concentration (HB), red blood cell (RBC) and white blood cell (WBC) counts. No significant change was also observed in all the biochemical parameters studied, including indices of hepatic and renal functions. The results of this study suggest that MSG at the doses administered is not hazardous to health.},
 year = {2013}
}

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TY  - JOUR
T1  - Assessment of the Effects of Monosodium Glutamate on Some Biochemical and Hematological Parameters in Adult Wistar Rats
AU  - Oyetunji Timothy Kolawole
Y1  - 2013/06/20
PY  - 2013
N1  - https://doi.org/10.11648/j.ajbio.20130101.13
DO  - 10.11648/j.ajbio.20130101.13
T2  - American Journal of BioScience
JF  - American Journal of BioScience
JO  - American Journal of BioScience
SP  - 11
EP  - 15
PB  - Science Publishing Group
SN  - 2330-0167
UR  - https://doi.org/10.11648/j.ajbio.20130101.13
AB  - Monosodium glutamate (MSG) is a compound popularly used to enhance food taste and flavor. Several reports of toxicity studies on MSG are contradictory. Therefore, there is growing concern regarding the safety of MSG as food additive. In the present study, the effect of orally administered MSG on food consumption, body weight and some biochemical and hematological parameters were investigated in adult rats. Following a 28-day treatment with 5-15 mg/kg body weight MSG, there were no significant changes in packed cell volume (PCV), hemoglobin concentration (HB), red blood cell (RBC) and white blood cell (WBC) counts. No significant change was also observed in all the biochemical parameters studied, including indices of hepatic and renal functions. The results of this study suggest that MSG at the doses administered is not hazardous to health.
VL  - 1
IS  - 1
ER  -

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Author Information

Oyetunji Timothy Kolawole

Department of Pharmacology and Therapeutics, College of Health Sciences, Ladoke Akintola University of Technology, Ogbomoso, Nigeria

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APA Style

Oyetunji Timothy Kolawole. (2013). Assessment of the Effects of Monosodium Glutamate on Some Biochemical and Hematological Parameters in Adult Wistar Rats. American Journal of BioScience, 1(1), 11-15. https://doi.org/10.11648/j.ajbio.20130101.13

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ACS Style

Oyetunji Timothy Kolawole. Assessment of the Effects of Monosodium Glutamate on Some Biochemical and Hematological Parameters in Adult Wistar Rats. Am. J. BioScience 2013, 1(1), 11-15. doi: 10.11648/j.ajbio.20130101.13

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AMA Style

Oyetunji Timothy Kolawole. Assessment of the Effects of Monosodium Glutamate on Some Biochemical and Hematological Parameters in Adult Wistar Rats. Am J BioScience. 2013;1(1):11-15. doi: 10.11648/j.ajbio.20130101.13

Copy | Download

@article{10.11648/j.ajbio.20130101.13,
  author = {Oyetunji Timothy Kolawole},
  title = {Assessment of the Effects of Monosodium Glutamate on Some Biochemical and Hematological Parameters in Adult Wistar Rats},
  journal = {American Journal of BioScience},
  volume = {1},
  number = {1},
  pages = {11-15},
  doi = {10.11648/j.ajbio.20130101.13},
  url = {https://doi.org/10.11648/j.ajbio.20130101.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbio.20130101.13},
  abstract = {Monosodium glutamate (MSG) is a compound popularly used to enhance food taste and flavor. Several reports of toxicity studies on MSG are contradictory. Therefore, there is growing concern regarding the safety of MSG as food additive. In the present study, the effect of orally administered MSG on food consumption, body weight and some biochemical and hematological parameters were investigated in adult rats. Following a 28-day treatment with 5-15 mg/kg body weight MSG, there were no significant changes in packed cell volume (PCV), hemoglobin concentration (HB), red blood cell (RBC) and white blood cell (WBC) counts. No significant change was also observed in all the biochemical parameters studied, including indices of hepatic and renal functions. The results of this study suggest that MSG at the doses administered is not hazardous to health.},
 year = {2013}
}

Copy | Download

TY  - JOUR
T1  - Assessment of the Effects of Monosodium Glutamate on Some Biochemical and Hematological Parameters in Adult Wistar Rats
AU  - Oyetunji Timothy Kolawole
Y1  - 2013/06/20
PY  - 2013
N1  - https://doi.org/10.11648/j.ajbio.20130101.13
DO  - 10.11648/j.ajbio.20130101.13
T2  - American Journal of BioScience
JF  - American Journal of BioScience
JO  - American Journal of BioScience
SP  - 11
EP  - 15
PB  - Science Publishing Group
SN  - 2330-0167
UR  - https://doi.org/10.11648/j.ajbio.20130101.13
AB  - Monosodium glutamate (MSG) is a compound popularly used to enhance food taste and flavor. Several reports of toxicity studies on MSG are contradictory. Therefore, there is growing concern regarding the safety of MSG as food additive. In the present study, the effect of orally administered MSG on food consumption, body weight and some biochemical and hematological parameters were investigated in adult rats. Following a 28-day treatment with 5-15 mg/kg body weight MSG, there were no significant changes in packed cell volume (PCV), hemoglobin concentration (HB), red blood cell (RBC) and white blood cell (WBC) counts. No significant change was also observed in all the biochemical parameters studied, including indices of hepatic and renal functions. The results of this study suggest that MSG at the doses administered is not hazardous to health.
VL  - 1
IS  - 1
ER  -

Copy | Download